黏液型铜绿假单胞菌感染实验鉴定和病例回顾分析

目的 探讨黏液型铜绿假单胞菌的临床分布特点及对常用抗菌药物敏感度。方法 对医院2013年分离的53株非重复性黏液型铜绿假单胞菌感染病例进行回顾性分析,通过查阅病历获得患者一般资料、疾病情况、抗生素使用等信息,并对菌株进行药敏分析。结果 所有菌株均分离自痰标本,患者以老年人为主,平均年龄66.7±9.1岁。50例患者有呼吸道感染的慢性病史; 所有患者住院期间均使用了2种或2种以上抗菌药物,联合使用过大环内酯类的仅11例。53株菌对临床常用的抗菌药物均表现了较高的体外敏感性,除替卡西林/克拉维酸(64.2%)、头孢吡肟(60.4%)以外,其它药物敏感率均高于70%。结论 黏液型铜绿假单胞菌的易感人群为老年有呼吸道感染慢性病史的患者,体外培养对抗菌药物敏感性较高,临床上多采用联合抗菌药物治疗,大环内酯类药物使用率较低。

Experimental Identification of Mucoid Pseudomonas Aeruginosa Strains Causing Infections and Cases Review

Objective To investigate the clinical distribution and antibacterial drug susceptibility of mucoid Pseudomonas aeruginosa(mPa).Methods By looking at the patients' general information,disease information and the information of antimicrobial usage,cases of 53 strains of non-repetitive mucoid Pseudomonas aeruginosa were collected from hospitalized patients from Jan 2013 to Dec 2013,and drug susceptibility wereanalyzed.Results A total of 53 strains of mucoid Pseudomonas aeruginosa were isolated from sputum specimen,mainly elderly patientswith a mean age of 66.7±9.1 years old; 50 patients had chronic history of respiratory infections,all patients were used during the hospital stay of two ormore kinds of antibiotics,used jointly only 11 cases of macrolides.All strainsto commonly used antimicrobial agents showed a higher sensitivity in vitro,inaddition to ticarcillin/clavulanate(64.2%),cefepime(60.4%),other drug sensitivity was higher than 70%.Conclusion Mucoid Pseudomonas aeruginosa was susceptible to chronic respiratory infection history of theelderly,its antimicrobial susceptibility was high in vitro,the use of antimicrobial agents in clinical was combined therapy compared,but utilization rate ofmacrolides drugs was low.