天晴日安治疗化疗后恶心呕吐的临床研究

目的观察选择性5-HT3受体拮抗剂———盐酸阿扎司琼氯化钠(天晴日安)预防化疗所致的消化道反应的临床疗效。方法随机选择52例化疗患者,治疗组26例,天晴日安10 mg,化疗前30 m in静注;对照组26例,盐酸恩丹西酮8 mg,静推,化疗前后15 m in应用。结果天晴日安对急性恶心的有效率为96.2%,恩丹西酮为92.3%;天晴日安对急性呕吐的有效率为100%,恩丹西酮为88.5%。天晴日安组便秘发生率42.3%,恩丹西酮组57.7%。结论天晴日安对化疗所致恶心呕吐具有良好的治疗作用,副作用小,且无锥体外系症状。

Efficacy of azasetron hydrochloride in the treatment of nausea and vomiting induced by chemotherapy

Objective To evaluate the efficacy of azastron hydrochloride in prevention of naesea and vomiting caused by cancer chemotherapy.Method Fifty-two patients were randomized to treament group(26 cases) and control group(26 cases).Results The rates of nausea-free were 96.2% and 92.3%,the rates of vomiting-free were 100% and 88.5%,and the rates of constipation were 42.3% and 57.7% in azastron and ondansetron groups respectively.Conclusion Azastron is effective in treatment of nausea and vomiting induced by chemotherapy,and its side effects are mild.