| 急性肾衰大鼠肾阻抗容积脉波的改变及三种莨菪药的治疗作用 |
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| 引用本文： | 吴广礼,田牛.急性肾衰大鼠肾阻抗容积脉波的改变及三种莨菪药的治疗作用[J].微循环学杂志,1998,8(2):16-17,31. |
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| 作者姓名： | 吴广礼 田牛 |
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| 作者单位： | 1. 白求恩国际和平医院肾内科,石家庄,050082
2. 中国人民解放军总医院微循环研究室 |
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| 摘 要： | 用自己建立的阻抗法描记大鼠肾容积脉波，研究油酸致急性肾衰时肾阻抗容积脉波的改变及樟柳碱、东莨菪碱、山莨菪碱对这些改变的影响。结果表明：左肾动脉注射油酸后１０ｍｉｎ、１ｈ、６ｈ出现低平及平顶波，波高及流入容积速度明显低于注射前及生理盐水对照组。三种莨菪药治疗后，低平及平顶波明显减少或消失，波高及流入容积速度明显提高。结果说明：急性肾衰早期肾内脉动血管弹性降低，紧张度增高，周围阻力增加，肾组织血液灌流量降低；三种莨菪药均可改善肾内脉动血管的功能，提高肾组织血液灌流量
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| 关 键 词： | 急性肾功能衰竭 油酸 阻抗式肾容积脉波 樟柳碱 东莨菪碱 山莨菪碱 |
Alterations of Renal Impedance Plethysmogram and Effect of Anisodine, Anisodamine and Buscopan on These Changes in Experimental Acute Renal Failure |
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| Abstract: | Alterations of renal impedance plethysmogram were observed, and effects of Anisodine, Anisodamine, Buscopan on these changes were studied in oleic acid induced acute renal failure rats. The results showed that the lower and plain waves appeared at 10 minutes, 1 hour, 6 hours after oleic acid injection to left renal artery and the values of wave amplitude and volume of inflow were significantly decreased in contrast with values before oleic acid injection to left renal artery and control group at above time points. Lower and plain waves attenuated or disappeared and the wave amplitude and volume of inflow were increased remarkably after treatment with Anisodine, Anisodamine and Buscopan. These results suggest that the flexibility was decreased, tension and resistance were increased in pulsing blood vessels of kidney, the blood flow of renal tissue was decreased after oleic acid injection to left renal artery. Anisodine, Anisodamine and Buscopan could improved the function of pulsing blood vessels of kidney and increased the blood flow of renal tissue in rats with acute renal failure. |
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| Keywords: | Acute renal failure Oleic acid Impedance plethysmogram of kidney Anisodine Anisodamine Buscopan |
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