| 高效液相色谱-质谱联用技术分析刺五加抗疲劳化学成分 |
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| 引用本文： | 王子灿,乔善义,马安德,鲍永耀. 高效液相色谱-质谱联用技术分析刺五加抗疲劳化学成分[J]. 南方医科大学学报, 2003, 23(4): 355-357 |
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| 作者姓名： | 王子灿 乔善义 马安德 鲍永耀 |
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| 作者单位： | 第一军医大学中心实验室,广东,广州,510515;军事医学科学院毒物药物研究所,北京,100850 |
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| 基金项目： | 国家高技术研究发展计划(863计划)(2001AA234021),全军医药卫生科研基金(01MA084)~~ |
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| 摘 要： | 刺五加粗提物经植化方法处理后,采用液相质谱(LC/MS/MS)联用技术进行分析。得到了LC/MS/MS联用的分析条件,取得较好分离效果,确定了数种已知及未知的化合物的所在部位。在其中一个部位,即11号样品中,发现5个已知成分和相对分子质量分别为302、318、346、354、390、406的6个未知成分。
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| 关 键 词： | 高效液相色谱 多级质谱 抗疲劳 刺五加 |
| 文章编号： | 1000-2588(2003)04-0355-03 |
| 修稿时间： | 2003-02-18 |
High-performance liquid chromatography combined with mass spectrum analysis for identifiying the antifatigue components in Acanthopanax senticosus Harms |
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| WANG Zi-can ,QIAO Shan-yi ,MA An-de ,BAO Yong-yao Central Laboratory,Frist Military Medical University,Guangzhou ,China. High-performance liquid chromatography combined with mass spectrum analysis for identifiying the antifatigue components in Acanthopanax senticosus Harms[J]. Journal of Southern Medical University, 2003, 23(4): 355-357 |
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| Authors: | WANG Zi-can QIAO Shan-yi MA An-de BAO Yong-yao Central Laboratory Frist Military Medical University Guangzhou China |
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| Affiliation: | WANG Zi-can 1,QIAO Shan-yi 2,MA An-de 1,BAO Yong-yao 11 Central Laboratory,Frist Military Medical University,Guangzhou 510515,China, 2 Institute of Toxicology and Pharmacology,Academy of Military Medical Scievces,Beijing 100850,China |
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| Abstract: | The roots of Acanthopanax senticosus(Rupr. et Maxim.) Harm were obtained for the acquisition of the crude extra- ctives to isolate the 19 components by means of preliminary extraction and isolation. High-performance liquid chromatography followed by primary and secondary mass spectrum analysis (HPLC/MS/MS) was employed to identify the antifatigue components from the extracts of the plant with reference to the literature. Good isolation results were achieved and several known and unknown chemical compounds were identified, for instance, in one sample (No. 11) 5 known components were detected along with 6 unknown compounds with relative molecular mass of 302, 318, 346, 354, 390, and 406, respectively. |
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| Keywords: | liquid chromatography mass spectra antifatigue Acanthopanax senticosus |
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