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The rs1333049 polymorphism on locus 9p21.3 and extreme longevity in Spanish and Japanese cohorts |
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| Authors: | Pinós Tomàs Fuku Noriyuki Cámara Yolanda Arai Yasumichi Abe Yukiko Rodríguez-Romo Gabriel Garatachea Nuria Santos-Lozano Alejandro Miro-Casas Elisabet Ruiz-Meana Marisol Otaegui Imanol Murakami Haruka Miyachi Motohiko Garcia-Dorado David Hinohara Kunihiko Andreu Antoni L Kimura Akinori Hirose Nobuyoshi Lucia Alejandro |
| Institution: | 1.Departament de Patología Mitocondrial i Neuromuscular, Institut de Recerca Hospital Universitari Vall d’Hebron, Barcelona, Spain ;2.Department of Genomics for Longevity and Health, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan ;3.Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan ;4.INEF, Universidad Politécnica, Madrid, Spain ;5.Facultad de Ciencias de la Salud y del Deporte, Universidad de Zaragoza, Huesca, Spain ;6.Departmento de Ciencias Biomédicas, Universidad de León, León, Spain ;7.Departamento de Cardiología, Hospital Universitari Vall d’Hebron, Barcelona, Spain ;8.Department of Health Promotion and Exercise, National Institute of Health and Nutrition, Tokyo, Japan ;9.Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan ;10.Universidad Europea and Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12), Madrid, Spain ;11.CIBER de Enfermedades Raras (CIBERER), Barcelona, Spain ; |
| Abstract: | GeroScience - The rs1333049 (G/C) polymorphism located on chromosome 9p21.3 is a candidate to influence extreme longevity owing to its association with age-related diseases, notably coronary artery... |
| Keywords: | Centenarians Genetics Coronary artery disease CDKN2A CDKN2B |
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