| 伊立替康联合氟尿嘧啶、亚叶酸钙二线治疗晚期结直肠癌的临床观察 |
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| 引用本文： | 曾继泽,ZHOU Hang,刘霄.伊立替康联合氟尿嘧啶、亚叶酸钙二线治疗晚期结直肠癌的临床观察[J].中国药房,2008,19(23):1812-1813. |
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| 作者姓名： | 曾继泽 ZHOU Hang 刘霄 |
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| 作者单位： | 曾继泽 (遵义医学院附属医院肿瘤医院二病区,遵义市,563003)； ZHOU Hang (遵义医学院附属医院肿瘤医院二病区,遵义市,563003)； 刘霄 (遵义医学院附属医院肿瘤医院二病区,遵义市,563003)； |
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| 摘 要： | 目的:观察FOLFIRI方案二线治疗晚期结直肠癌的疗效及安全性。方法:28例FOLFOX4化疗失败的患者,改用FOLFIRI方案挽救化疗。结果:完全缓解为0例,部分缓解6例,稳定16例,进展6例,有效率21.4%。不良反应主要为恶心、呕吐、白细胞减少和延迟性腹泻。结论:FOLFIRI方案二线治疗晚期结直肠癌,疗效肯定,不良反应可控制。
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| 关 键 词： | 伊立替康 氟尿嘧啶 亚叶酸钙 晚期结直肠癌 化学治疗 |
Clinical Observation of Irinotecan in Combination of Fluorouracil and Calcium Folinate as A Second Line Treatment for Advanced Colorectal Cancer |
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| ZENG Ji-ze,ZHOU Hang,LIU Xiao.Clinical Observation of Irinotecan in Combination of Fluorouracil and Calcium Folinate as A Second Line Treatment for Advanced Colorectal Cancer[J].China Pharmacy,2008,19(23):1812-1813. |
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| Authors: | ZENG Ji-ze ZHOU Hang LIU Xiao |
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| Abstract: | OBJECTIVE:To observe the clinic efficacy and safety of FOLFIRI as a second line treatment for patients with advanced colorectal cancer.METHODS:Twenty-eight patients with advanced colorectal cancer whose disease progressed after first treatment with FOLFOX4 were included to receive the second line treatment with FOLFIRI regimen.RESULTS:Of the total 28 cases,0 had complete response,6 partial response,16 stable disease,6 progressive disease,and the responsive rate was 21.4%.The majority of adverse reaction was nausea,vomiting,leucopenia and tardive diarrhea.CONCLUSION:As a second line therapy,FOLFIRI has a confirmed therapeutic response and tolerable toxicity in patients with advanced colorectal cancer. |
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| Keywords: | Irinotecan Fluorouracil Calcium folinate Advanced colorectal cancer Chemotherapy |
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