| p38 MAPK mediates cardiovascular and behavioral responses induced by central IL-1β and footshock in conscious rats |
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| 作者姓名： | Rui-mao ZHENG Chang-jiang ZOU Shi-gong ZHU2 Department of Physiology and Pathophysiology Health Science Center Peking University Beijing 100083 China |
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| 作者单位： | Rui-mao ZHENG，Chang-jiang ZOU，Shi-gong ZHU2 Department of Physiology and Pathophysiology，Health Science Center，Peking University，Beijing 100083，China |
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| 基金项目： | Project supported by a grant from the National Major BasicResearch Program ofChina (G2000056908). |
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| 摘 要： | ![]()
INTRODUCTION Sharing characteristics of stress mediators[1], cen-tral interleukin-1β (IL-1β) is very important in cardio-vascular and behavioral responses to stressors[2-4]. Itcan induce similar hypertensive responses to stress viacardiovascular regulatory regions[5]. We observed pre-viously that central IL-1β mediated cardiovascular re-sponses to some stressful stimuli, such as conditionedfear stimuli and footshock[6]. Many stressful stimulimay increase IL-1β mRNA expression and …
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| 关 键 词： | p38促细胞分裂蛋白激酶 白细胞介素-1β 细胞因子 心血管病 血压 动物模型 脑室注射 |
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