尼莫地平对脑卒中后血管性认知功能障碍的防治

目的观察尼莫地平防治脑卒中后早期血管性认知功能障碍(VCI)的临床疗效。方法对照组给予常规治疗。观察组在此基础上加用尼莫地平120 mg/d,连续12周。记录两组患者治疗前后的MMSE、MoCA评分。比较两组治疗前后血管性认知功能障碍的改善情况。结果治疗12周后,观察组MMSE、MoCA评分均较治疗前有显著变化,前后比较差异有统计学意义(P<0.01);对照组MMSE、MoCA评分用药前后有变化,差异有统计学意义(P<0.05)。两组治疗后MMSE、MoCA评分观察组较对照组改善明显,差异有统计学意义(P<0.05)。治疗过程中观察组未出现严重副作用。结论尼莫地平预防及治疗早期血管性认知障碍疗效确切。合理使用改善认知功能药物,及生活方式的干预,可以延缓血管性痴呆的发生。

Effect of nimodipine on cerebral vascular cognitive impairment after stroke prevention and treatment

Objective To study the protective effect and clinical efficacy of nimodipine on stroke in early stage of vascular cognitive impairment(VCI).Methods TThe control group was given routine treatment.The observation group was treated by conventional method combined with 120mg /d nimodipine for 12 consecutive weeks.MMSE,MoCA score of two groups were recorded before and after treatment.The improvement of vascular cognitive impairment of the two groups before and after treatment was compared.Results Twelve weeks after the treatment,MMSE,MoCA score of the observation group had significant changes compared with those before treatment,and the difference was statistically significant(P< 0.01);MMSE,MoCA score of the control group had changes before and after medication,and there was statistically significant difference(P<0.05).After the treatment,MMSE,MoCA score in observation group were improved significantly compared with those in the control group,and there was statistically significant difference(P<0.05).During the treatment side effects did not appear in the observation group.Conclusion Nimodipine has confirmed effect on the prevention and treatment of early vascular cognitive impairment.The rational use of drugs to improve cognitive function and lifestyle intervention can delay the occurrence of vascular dementia.