母乳喂养早产儿血清维生素E水平动态变化

目的：探讨母乳喂养健康早产儿血清维生素E水平的动态变化以及临床对于健康早产儿是否需要常规补给维生素E。方法：38例母乳喂养的健康早产儿随机分成干预组(n=20)和对照组(n=18),干预组早产儿于出生当天第1次采血后每天给予维生素E 50 mg肌肉注射,连续3 d;对照组不给予维生素E。用荧光分光光度计测定两组早产儿出生后0,10,30 d的血清维生素E水平,并作比较分析。结果：两组早产儿出生时血清维生素E水平,干预组1.64±0.68 mg/dL;对照组1.76±0.74 mg/dL差异无显著性(P>0.05);两组早产儿在生后10 d时血清维生素E均呈升高趋势,干预组2.54±1.23 mg/d l,对照组2.64±1.13 mg/dL,两组间差异无显著性,(P>0.05)。生后30 d时,干预组血清维生素E仍维持原增高水平,而对照组血清维生素E呈下降趋势,干预组2.77±1.56 mg/dL,对照组为2.37±1.07两组差异无显著性(P>0.05)。各时间点,两组早产儿血清维生素E均高于0.5 mg/dL(范围0.59~6.45 mg/dL)。结论：母乳喂养健康早产儿生后30 d内血清维生素E与用维生素E干预组比较无显著差别,且两组早产儿都无维生素E缺乏发生。故认为对于母乳喂养早产儿无需常规补给维生素E。[中国当代儿科杂志,2005,7(6):503-505]

Serum vitamin E level in healthy breast-feeding premature infants

OBJECTIVE: There is controversy as to whether vitamin E supplementation is essential for healthy breast-feeding premature infants. This study examined the dynamic changes of the serum vitamin E level in healthy breast-feeding premature infants within 30 days after birth. METHODS: Thirty-eighty healthy breast-feeding premature infants were randomized to receive vitamin E supplementation (Intervention group, n=20) or without (Control group, n=18). The Intervention group was intramuscularly injected with vitamin E 50 mg daily for 3 days soon after birth.Blood samples were collected at birth (before the first vitamin E injection), and 10 and 30 days after birth. The serum vitamin E level was measured by spectrophotofluorometer. RESULTS: The vitamin E level of the Intervention group (1.64±0.68 mg/dL) was no significantly different from that of the Control group (1.76±0.74 mg/dL) (P>0.05) at birth. The Vitamin E level of the both groups increased 10 days after birth, and there was no significant difference between the two groups (2.54±1.23 mg/dL vs 2.64±1.13 mg/dl,P>0.05). On the 30th day after birth, the vitamin E level of the Intervention group remained high but that of the Control group decreased, although there was no significant difference between the two groups (2.77±1.56 mg/dL vs 2.37±1.07 mg/dL, P>0.05). No patient had the serum level of less than 0.5 mg/dL at any time point (reference range (0.59-6.45) mg/dL). CONCLUSIONS: There was no significant difference in serum vitamin E level between the two groups within 30 days after birth.The healthy breast-feeding premature infants were not vitamin E deficient.Thus Vitamin E supplementation is not necessary for healthy breast-feeding premature infants.