中西医结合联合TDP照射治疗盆腔炎性疾病后遗症68例

探讨中西医结合联合TDP（特定电磁波辐射器）照射治疗盆腔炎性疾病后遗症（SPID）的疗效。方法：将104例患者随机分为单纯西医治疗组（对照组）和中西医结合联合TDP照射治疗组（治疗组）。对照组采用头孢曲松钠、奥硝唑等静脉点滴,治疗组采用头孢曲松钠、奥硝唑等静脉点滴外,配合中药口服、灌肠并联合TDP照射。结果：治疗组抗生素使用时间缩短,治愈率和总有效率明显高于对照组（P〈0.01）。结论：中西医结合联合TDP照射治疗SPID疗效明显高于单纯西医治疗。     

针刺推拿加特定电磁波谱治疗器治疗急性腰扭伤63例临床体会

目的:探讨针刺推拿加特定电磁波谱治疗器(TDP)治疗急性腰扭伤的疗效。方法:对63例急性腰扭伤患者的临床资料进行回顾性分析。结果:治愈43例,显效11例,有效6例,无效3例。结论:多数患者经针刺推拿加TDP治疗取得满意效果。临床通过针刺推拿加TDP治疗急性腰扭伤,不仅能够缩短疗程,而且可以提高疗效。     

Enhancement of native and phosphorylated TDP‐43 immunoreactivity by proteinase K treatment following autoclave heating

TDP‐43 is a major disease protein in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TDP‐43 (FTLD‐TDP). To evaluate the effectiveness of proteinase K (PK) treatment in antigen retrieval for native and phosphorylated TDP‐43 protein, we examined the temporal cortex and spinal cord from patients with sporadic ALS and FTLD‐TDP and control subjects. PK treatment following heat retrieval enhanced the immunoreactivity for native TDP‐43 in controls as well as for native and phosphorylated TDP‐43 in ALS and FTLD‐TDP. A significant number of TDP‐43‐positive neuropil threads were demonstrated in lesions, in which routine immunohistochemistry revealed that the predominant inclusions are cytoplasmic. This retrieval method is the best of immunohistochemical techniques for demonstrating TDP‐43 pathology, especially in the neuropil.     

Coexistence of TDP‐43 and tau pathology in neurodegeneration with brain iron accumulation type 1 (NBIA‐1, formerly Hallervorden‐Spatz syndrome)

We report here an autopsy case of sporadic adult‐onset Hallervorden‐Spatz syndrome, also known as neurodegeneration with brain iron accumulation type 1 (NBIA1), without hereditary burden. A 49‐year‐old woman died after a 27‐year disease course. At the age of 22, she suffered from akinesia, resting tremor, and rigidity. At the age of 28, she was admitted to our hospital because of worsening parkinsonism and dementia. Within several years, she developed akinetic mutism. At the age of 49, she died of bleeding from a tracheostomy. Autopsy revealed a severely atrophic brain weighing 460 g. Histologically, there were iron deposits in the globus pallidus and substantia nigra pars reticulata, and numerous axonal spheroids in the subthalamic nuclei. Neurofibrillary tangles were abundant in the hippocampus, cerebral neocortex, basal ganglia, and brain stem. Neuritic plaques and amyloid deposits were absent. Lewy bodies and Lewy neurites, which are immunolabeled by anti‐α‐synuclein, were absent. We also observed the presence of TDP‐43‐positive neuronal perinuclear cytoplasmic inclusions, with variable frequency in the dentate gyrus granular cells, frontal and temporal cortices, and basal ganglia. TDP‐43‐positive glial cytoplasmic inclusions were also found with variable frequency in the frontal and temporal lobes and basal ganglia. The present case was diagnosed with adult‐onset NBIA‐1 with typical histological findings in the basal ganglia and brainstem. However, in this case, tau and TDP‐43 pathology was exceedingly more abundant than α‐synuclein pathology. This case contributes to the increasing evidence for the heterogeneity of NBIA‐1.     

Semantic dementia with lower motor neuron disease showing FTLD‐TDP type 3 pathology (sensu Mackenzie)

We describe a case of frontotemporal lobar degeneration with semantic dementia and lower motor neuron disease. A 63‐year‐old man presented with the full clinical picture of semantic dementia, including semantic anomia, surface alexia, lexical agraphia, associative agnosia, prosopagnosia and phonagnosia. Flaccid dysarthria, bulbar dysphagia and fasciculations developed 7 years after onset, followed by death within a year. The neuropathological examination showed heavy neuronal loss in the anterior temporal lobe cortex, dorsal vagal and hypoglossal nuclei and anterior horns of the spinal cord. Ubiquitin‐ and TDP‐43‐positive cytoplasmic inclusions were abundant in layer II of affected cortices and in granular cells of the hippocampal dentate gyrus, whereas dystrophic neurites were sparse and intranuclear inclusions absent. It is concluded that FTLD‐TDP type 3 can be associated with semantic dementia and lower motor neuron disease in combination.     

Amyotrophic lateral sclerosis and neurosarcoidosis: A case report

Amyotrophic lateral sclerosis (ALS) remains a clinical diagnosis without definable biomarkers. The pathomechanism of motor neuron degeneration in ALS has yet to be elucidated. Here we present a case of limb‐onset ALS, with autopsy findings of Bunina bodies and skein‐like inclusions, as well as sarcoid granulomas predominating among motor neurons. The targeting of the motor neurons by the sarcoid inflammation raises questions regarding the role of cellular immunity in the pathomechanisms for ALS. Muscle Nerve, 2009     

双柏散敷药联合特定电池波谱照射治疗腰椎间盘突出症疗效观察及护理

目的探讨双柏散敷药联合特定电池波谱(TDP)照射治疗腰椎间盘突出症疗效,并总结护理要点。方法将125例腰椎间盘突出症患者随机分为观察组65例与对照组60例,对照组患者采用推拿、电针理疗法,观察组患者在对照组的基础上加双柏散敷药联合TDP照射。观察两组患者两个疗程后疼痛及治疗情况。结果两组患者治疗后疼痛VAS评分及治疗效果比较,均P0.05,差异具有统计学意义,观察组患者疼痛评分明显低于对照组,治疗效果明显优于对照组。结论在推拿、针灸等理疗基础上,加双柏散敷药联合TDP照射可提高椎间盘突出症治疗效果和缓解腰患者疼痛程度。护理方面应做好敷药及TDP照射护理工作。     

解毒生肌膏联合TDP治疗Ⅲ期压疮的疗效观察及护理

目的探讨自制解毒生肌膏联合TDP照射治疗Ⅲ期压疮的临床疗效及护理措施。方法将80例压疮患者随机分为观察组和对照组。观察组42例，常规清创消毒后用自制解毒生肌膏联合TDP照射；对照组38例，创面处理后用庆大霉素湿敷。同时采取相应的护理措施，并进行两组对照评估。结果观察组治愈率95．24％，对照组治愈率52．63％（P〈0．05）；观察组总有效率100％，对照组总有效率84．21％（P〈0．05）；观察组平均治愈时间明显较对照组缩短（P〈0．001）。结论解毒生肌膏联合TDP照射治疗压疮效果满意．可缩钶治疗时间．