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排序方式: 共有508条查询结果,搜索用时 0 毫秒
1.
实验动物口服骨痹通天丸5.58g/kg.2.79g/kg,观察本品对炎症反应,局部疼痛和免疫功能的影响。结果表明,骨痹通天丸的两个剂量组对大鼠蛋清性关节肿具有不同程度的抑制作用(P<0.01或0.05);对二甲苯性耳廓肿仅大剂量组具有明显抑制作用(P<0.01);对小鼠热刺激所致的疼痛反应具有不同程度的抑制作用(P<0.01或0.05);对化学刺性疼痛两个剂量组均有明显抑制作用(P<0.01);并可抑制小鼠重要免疫器官的增长和巨噬细胞的吞噬功能(P<0.05),对血清溶血素未显示其效应。 相似文献
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Rapid non-genomic inhibitory effects of glucocorticoids on human neutrophil degranulation 总被引:4,自引:0,他引:4
L. Liu Y. X. Wang J. Zhou F. Long H. W. Sun Y. Liu Y. Z. Chen C. L. Jiang 《Inflammation research》2005,54(1):37-41
Background: Glucocorticoids acting as anti-inflammatory or immunosuppressive drugs have been shown to exert most of their effects genomically. Recent findings suggest that non-genomic activity might be relatively more important in mediating the therapeutic effects of high-dose pulsed glucocorticoid. However, few non-genomic anti-inflammatory effects were reported, much less non-genomic mechanisms.Objective: This study was performed to investigate the nongenomic effects of glucocorticoids on human neutrophil degranulation.Methods: Purified human neutrophils were pretreated with 6 -methylprednisolone or hydrocortisone for 5 min, and then primed with N-formyl-methionyl-leucyl-phenylalanine (fMLP) (10–6 M) or phorbol myristate acetate (PMA) (50 ng/ml) in the presence of cytochalasin B. The release of two markers of neutrophil granules, lactoferrin and myeloperoxidase, was measured by ELISA and enzymology methods respectively.Results: Both 6 -methylprednisolone (10–5–10–4 M) and hydrocortisone (10–4 M) showed significant inhibitory effects on neutrophil degranulation within 5 min after fMLP administration. For PMA stimulated degranulation, 6 -methylprednisolone (10–4 M) showed significant inhibitory effects (p < 0.01), while hydrocortisone (10–4 M) only showed an inhibitory tendency (P > 0.05). Neither RU486 (10–5 M) nor cycloheximide (10–4 M) could alter the inhibitory effects of glucocorticoids.Conclusion: Our results demonstrate that megadoses of glucocorticoids exert rapid inhibitory effects on human neutrophil degranulation at the cellular level via a new mechanism that is independent of corticosteroid type II receptor occupation or protein synthesis. We infer that these effects may be very important when glucocorticoids act as anti-inflammatory drugs during pulse therapy.Received 20 May 2004; returned for revision 21 July 2004; accepted by M.J. Parnham 23 September 2004L. Liu and Y. X. Wang contributed equally to this work. 相似文献
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虎杖提取物抗炎作用的实验研究 总被引:9,自引:0,他引:9
[目的]考察虎杖的乙酸乙酯提取物的抗炎作用及初步机制。[方法]分别以地塞米松、阿司匹林和环磷酰胺为阳性对照药,采用虎杖的乙酸乙酯提取物对小鼠和大鼠的多种炎症模型进行抑制实验。[结果]虎杖的乙酸乙酯提取物对角叉菜胶所致大鼠足跖肿胀有显著抑制作用(P<0.00 J);对小鼠、大鼠纸片法所致肉芽肿有显著抑制作用(P<0.01);对腹腔注射醋酸所致小鼠毛细血管通透性增高有显著抑制作用(P<0.01);对角叉菜胶所致小鼠肿胀足中炎症介质PGE2合成有显著抑制作用(P<0.001);对三硝基氯苯诱导的小鼠迟发性超敏反应有显著抑制作用(P<0.01);对肾上腺切除大鼠纸片法致肉芽肿(P<0.01)及角叉菜胶所致足跖肿胀(P<0.05)有显著抑制作用,但其抑制率均较正常大鼠相应实验抑制率有所降低。[结论]虎杖的乙酸乙酯提取物有一定的抗炎作用,其作用机制可能是抑制炎症介质PGE2的合成、抑制细胞免疫及与垂体-肾上腺皮质系统有关。 相似文献
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目的:探讨银屑宁胶囊的抗炎清热作用。方法:银屑宁胶囊灌胃大小鼠一段时间后,用二甲苯诱发小鼠耳廓部急性炎性水肿和小鼠腹部皮肤毛细血管通透性亢进,将新鲜蛋清和鹿角菜胶悬液大鼠皮下注射造成其足跖肿胀,同时用2,4-硝基苯酚溶液和干酵母悬液诱发大鼠全身发热。结果:银屑宁胶囊对大鼠鹿角菜胶,蛋清性足肿胀及小鼠二甲苯所致的耳肿胀有明显的抑制作用,可明显拮抗小鼠皮肤毛细血管通透性亢进。同时能明显抑制干酵母及2,4-二硝基苯酚所引起的大鼠全身性发热。结论:银屑宁胶囊具有良好的抗炎清热作用。 相似文献
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盆腔舒胶囊抗炎镇痛作用及对子宫收缩影响 总被引:2,自引:0,他引:2
目的: 通过盆腔舒胶囊对慢性炎症的抗炎及镇痛作用研究,探讨其治疗慢性盆腔炎的作用机制。方法:抗炎作用采用二甲苯小鼠耳廓肿胀模型、大鼠子宫炎症模型、小鼠滤纸片肉芽肿增生模型;镇痛作用采用小鼠热板法及小鼠扭体反应法;对家兔子宫的影响采用对正常家兔体外子宫平滑肌收缩的影响和对缩宫素所致家兔体外子宫平滑肌收缩的影响两种方法。结果:盆腔舒胶囊抗炎作用优于妇科千金片,接近氢化可的松;镇痛作用强于妇科千金片,接近阿司匹林;对正常家兔和对缩宫素所致家兔体外子宫平滑肌的抑制作用优于妇科千金片,接近阿托品。结论:盆腔舒胶囊具有良好的抗炎,镇痛及抑制子宫平滑肌收缩的作用。 相似文献
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目的筛选出唐古特瑞香抗炎镇痛的活性部位。方法采用醋酸扭体法、小鼠腹腔毛细血管通透性试验以及二甲苯致小鼠耳肿胀试验,分别以小鼠扭体反应次数、毛细管通透性、小鼠耳肿胀度以及胀抑制率为考察指标,对唐古特瑞香的乙醚部位、50%乙醇部位、30%乙醇部位、水部位进行抗炎镇痛药效筛选。结果唐古特瑞香乙醚部位(0.44 g/kg)可明显减少冰醋酸所致的小鼠扭体次数(P<0.01)及冰醋酸所致小鼠毛细血管通透性增加(P<0.01)和抑制二甲苯所致小鼠耳肿胀(P<0.05)。结论唐古特瑞香乙醚部位为抗炎镇痛的药效部位,为唐古特瑞香开发研究提供科学依据。 相似文献
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Ethnopharmacological relevance
Cassia sophera Linn (Family Caesalpiniaceae), popularly known as kasundi, is used both in the Indian traditional system and folk medicine to treat several inflammatory pathologies such as asthma, arthritis and pains. The aim of the present study was to evaluate the scientific basis of anti-inflammatory activity of Cassia sophera ethanol extracts and of an isolated constituent of Cassia sophera.Materials and methods
The anti-inflammatory activity of Cassia sophera was studied using the carrageenan, dextran induced rat paw edema, and cotton pellet induced granuloma in rats. The ethanol extract was administered at the concentrations of 200 and 400 mg/kg body weight whereas rhamnetin (RN) was administered at a dose of 10 and 15 mg/kg, b.w. Indomethacin was used as standard drug.Results
The HPLC analysis revealed that good amounts of rhamnetin (0.18%) was present in Cassia sophera.The ethanol extracts at 400 mg/kg, showed maximum inhibition of inflammation induced by carrageenan (44%), dextran (40%), cotton pellets (37.47%). On the other hand rhamnetin (15 mg/kg) exhibited maximum anti-inflammatory effect, that is 79 and 33% at the end of 3 h with carrageenin, and dextran-induced rat paw edema, respectively. In a chronic test rhamnetin (15 mg/kg) showed 43.32% reduction in granuloma weight.Conclusion
The marked inhibitory effect on paw edema and granuloma showed that Cassia sophera possess remarkable anti-inflammatory activity which may be due to rhamnetin at least in part, supporting the folkloric usage of the plant to treat various inflammatory diseases. 相似文献10.