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胃癌癌前病变中医证候与凋亡相关癌基因mRNA表达的关系   总被引:4,自引:1,他引:3  
【目的】 探讨胃癌癌前病变(PLGC)中医证候与bcl-2癌基因和p53抑癌基因mRNA表达的关系。【方法】经胃镜及病理证实为PLGC病例共40例,其中中度异型增生24例,重度异型增生9例,不完全性结肠化生7例;兼气滞证10例,兼胃热证12例,兼血瘀证18例。采用原位分子杂交的方法检测胃粘膜活检标本bcl-2癌基因和p53抑癌基因mRNA表达。【结果】本组PLGC中,bcl-2癌基因和p53抑癌基因在转录水平均有过度表达,并随病变的进展而表达逐渐增高。在不同的兼证中,bcl-2癌基因和p53抑癌基因mRNA的表达强度依次为兼气滞证<兼胃热证<兼血瘀证。【结论】bcl-2癌基因和p53抑癌基因在PLGC中有异常表达,其表达与不同兼证有关且可能有一定的证候特异性。  相似文献   
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Treatment of psychological problems of 59 children with a physical intersex condition is described. The group consisted of 18 female pseudohermaphrodites with congenital adrenal hyperplasia (CAH), 20 male pseudohermaphrodites and 2 true hermaphrodites born with ambiguous external genitalia assigned the female sex (ambiguous girls), 14 male pseudohermaphrodites born with completely female external genitalia and assigned the female sex (completely female group), and 5 male pseudohermaphrodites born with ambiguous external genitalia and assigned the male sex. Despite the sex assignment, genital organ correction soon after birth, psychological counseling of parents and intensive psychotherapy of the children, general psychopathology developed equally in all 4 groups (39% of total group). Although 87% of the girls with a physical intersex condition developed in line with the assigned sex, 13% developed a gender identity disorder though only 1 girl (2%) failed to accept the assigned sex. Gender identity disorder and deviant gender role were in evidence only in girls with CAH and girls of the ambiguous group. Biological and social factors seem responsible for the development of gender identity disorder, such as pre- and postnatal hormonal influences on the brain enabling deviant gender role behavior to develop, and an inability on the part of parents to accept the sex assignment. A reconsideration of the sex assignment in male pseudohermaphrodites and true hermaphrodites born with ambiguous external genitalia is discussed.  相似文献   
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Background: Bariatric surgery results in significant weight loss, improvement or cure of accompanying illnesses, and may lead to important changes in psychological conditions. The aim of this paper is to study the changes in the psychological and emotional lives of patients as well as quality of life during the first 2 years after vertical banded gastroplasty (VBG). Methods: The study population comprised 59 patients, 45 women (76.3%) and 14 men, between 18 and 64 years old. Patients were asked to complete an SCL-90R questionnaire before VBG. 2 years after VBG, patients were again asked to complete an SCL-90R as well as a BAROS questionnaire. Comparisons were made between loss of weight, alteration in the psychological condition and quality of life postoperatively, within the parameters of sex, age, marital status, level of education, duration of obesity and family history of obesity. Results: Women had a greater degree of depression from obesity than their male counterparts before the procedure (P=0.001), while their postoperative emotional improvement was more marked (P=0.008). The General Mental Health Index was higher in female than male patients (P=0.008). At 2 years after VBG, BMI was significantly reduced (P<0.001). Oversensitivity in personal relationships and anxiety affected patients more both pre- and postoperatively. The averages of all the indexes of the subgroups of the SCL-90R, which relates to psychological condition of patients, showed a statistically significant reduction at 2 years following VBG, indicative of the improvement of the patients' psychosomatic condition. The more weight patients lost, the more their quality of life improved, as evaluated by the BAROS (P<0.001). Conclusions: The bariatric surgery most satisfactorily improved the patients' psychosomatic condition, as well as their quality of life, during the first 2 years after VBG.  相似文献   
4.
This study focuses on the novel preparation of gelatin nanoparticles by nanoprecipitation. The principal parameters studied for its optimum conditions were the concentration of emulsifier, the time of emulsifier addition, the concentration of gelatin in solvent phase and the non-solvent volume. In addition, the effect of type of non-solvent (ethanol, n-propanol, methanol) was also studied. It was notable that emulsifier should exist in the non-solvent phase to prevent aggregation of gelatin nanoparticles prepared by nanoprecipitation. The emulsifier to gelatin mass ratio of 32:1 was found to be appropriate to fabricate stable nanoparticles without inter-particle aggregation caused by charge neutralization, during the course of cross-linking. The yield of gelatin nanoparticles was calculated gravimetrically after freeze drying. The freeze-dried nanoparticles were characterized for size and morphology by scanning electron microscopy. The division between nanoparticles was found most clear and vivid in the freeze-drying-induced matrix, owing to the least inter-particle aggregation during the process of cross-linking, for the case of 2% (w/v) emulsifier. The morphology of the freeze-dried nanoparticles turned out to be a spherical or hexagonal regular shape with a smooth surface in the freeze-drying-induced matrix. Their number-mean size is barely 115 nm and their unimodal size-mean is 215 nm with an unimodal polydispersity of 0.1547, the former of which is much smaller and the latter belongs to the lower limit of the gelatin nanoparticle size of 200–500 nm prepared by the coacervation method. Thus, as far as the morphology and the size of prepared gelatin nanoparticles are concerned, the optimum conditions may be derived from those of the above-mentioned morphology. The comparative experiments performed using the coacervation method turned out to require stirring and the nanoparticles still exhibited stability problems, even in the presence of emulsifier. Therefore, the results presented in this study show the optimum conditions and reflect the unexploited potential of the nanoprecipitation method for the preparation of nanoparticles from hydrophilic polymers like gelatin.  相似文献   
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