首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   93篇
  免费   3篇
  国内免费   2篇
妇产科学   1篇
基础医学   26篇
口腔科学   15篇
临床医学   7篇
内科学   11篇
神经病学   4篇
特种医学   1篇
外科学   3篇
综合类   3篇
预防医学   2篇
药学   18篇
中国医学   2篇
肿瘤学   5篇
  2022年   2篇
  2021年   2篇
  2020年   2篇
  2019年   5篇
  2018年   5篇
  2017年   1篇
  2016年   1篇
  2015年   1篇
  2014年   6篇
  2013年   12篇
  2012年   5篇
  2011年   8篇
  2010年   3篇
  2009年   1篇
  2008年   2篇
  2007年   7篇
  2006年   6篇
  2005年   2篇
  2004年   3篇
  2003年   3篇
  2002年   3篇
  2001年   2篇
  2000年   2篇
  1999年   3篇
  1998年   1篇
  1996年   1篇
  1995年   2篇
  1992年   2篇
  1985年   1篇
  1983年   2篇
  1978年   1篇
  1977年   1篇
排序方式: 共有98条查询结果,搜索用时 15 毫秒
1.
2.
3.
目的:探讨癫痫及癫痫性精神障碍患者的护理干预效果。方法对22例癫痫及癫痫性精神障碍患者在药物治疗同时予以有针对性的护理干预,观察患者的病情变化。结果本组患者均获得临床治愈或好转出院。结论癫痫及癫痫性精神障碍患者的治疗及护理干预是一个持续的过程,良好的护理干预对患者的康复具有重要作用。  相似文献   
4.
膝关节摆动(VAG)信号是指膝关节屈曲或伸展时发出的声音或振动信号,可灵敏、客观地描述膝关节的健康状态,在膝关节疾病的无创检测中具有重要作用。现有的对VAG信号正常和异常分类方法自动化程度低,且分类准确度较低,总体性能有待进一步提升。因此,提出一种基于改进卷积神经循环网络(PCNN-LSTM)的VAG信号分类算法。首先,利用经验模式分解(EMD)和小波变换,将一维VAG信号变换为二维时频特征谱图,并将其用作数据集;然后,在串行神经网络的基础上融合并行卷积神经网络结构,再与LSTM神经网络相结合构成改进的PCNN-LSTM模型,以此区分正常或异常的VAG信号,实现对膝关节健康状态的自动检测。采用由加速度传感器(181A02)和USB采集仪(FSC812)所采集的真实VAG信号,构建数据集对所提出算法性能进行验证。数据集由654例样本构成,其中包括健康数据222例和患有膝关节疾病的数据432例。实验表明,所提出算法的分类正确率为96.93%,灵敏度为100%,特异性为95.56%,相比其他算法可得到较好的分类识别效果,对于膝关节疾病的无创检测和辅助诊断具有重要意义。  相似文献   
5.

Background

The removal of the olfactory bulbs has been attributed to behavioral changes and neuroplasticity manifesting themselves among others like increases in brain neurotrophin expression and neurogenesis. Earlier data presented that EMD386088, a 5-HT6 receptor partial agonist, exerts antidepressant-like properties after chronic administration in olfactory bulbectomy (OB) model as was it compared with amitriptyline (AMI). The aim of this study was to compare acute and chronic biochemical effects of EMD386088, administered in its antidepressant active (2.5 mg/kg) and non-active (1.25 mg/kg) doses, found in the open field test in OB rats, with those of AMI (10 mg/kg). The levels of 5-HT6 receptor protein and selected neurotrophins in prefrontal cortex (PFC) and hippocampus (Hp) of rats have been examined.

Methods

5-HT6 receptor protein and selected neurotrophins: brain-derived neurotrophic factor (BDNF), cAMP-response element binding protein (CREB), the product of the immediate early gene c-fos (cFos) protein levels were assessed using a Western blot analysis in PFC and Hp of bulbectomized rats after acute or chronic (14-day) EMD386088 or AMI intraperitoneal (ip) treatment.

Results

The acute treatment with EMD386088 caused significant increases in CREB and BDNF protein levels in PFC, and an increase in BDNF in Hp of OB rats, while AMI injection decreased CREB and did not change BDNF levels. After the chronic administration of EMD386088, the increasing levels of BDNF and CREB were still observed in PFC and Hp.

Conclusions

The antidepressant-like effect of EMD386088 may be associated with the neuroplasticity activation in PFC and Hp in rats.  相似文献   
6.
Monoclonal antibodies (mAbs) against growth factors, receptors and tumor-specific/tumor-selective antigens represent a rapidly growing class of pharmaceutical agents which are poised to make a major impact on the treatment of colorectal cancer. mAbs targeting the epidermal growth factor receptor and the vascular endothelial growth factor have already been approved for the treatment of metastatic colorectal cancer. Other antibodies to the same and other molecular targets implicated in tumor growth and metastasis are undergoing intense preclinical and clinical evaluation. In both the neoadjuvant and adjuvant clinical settings, although mAbs are typically administered in combination with established cytotoxic chemotherapy regimens given their synergistic effect, several agents have demonstrated efficacy when given as monotherapy. At the same time, combination therapies with multiple targeted biological agents are actively being investigated. Existing clinical data and recent progress in preclinical and clinical studies of mAbs are reviewed.  相似文献   
7.
To date, the use of positive inotropic agents for the treatment of heart failure has not been a success. Not only have these drugs had little documentable beneficial effect on survival, but in some instances, most notably with the phosphodiesterase inhibitors, they have-caused an unacceptable increase in early mortality due to arrhythmias [1]. This has led to a body of opinion in some quarters that positive inotropic therapy for heart failure is a doomed approach and that all efforts should be concentrated on preventing or reversing atheroma, enhancing blood flow to the myocardium and dealing with the effects of secondary compensatory mechanisms. Although everyone agrees that prevention is better than cure, it seems inevitable that there will always be substantial numbers of patients with heart failure of various degrees of severity. Thus, it is important to be very sure of the facts before abandoning any hope of pharmacological contractile support for these patients. This article briefly reviews current evidence on the potential utility of calcium sensitisers.  相似文献   
8.
Isolated limb perfusion (ILP) with melphalan and tumor necrosis factor (TNF)‐α is used to treat bulky, locally advanced melanoma and sarcoma. However, TNF toxicity suggests a need for better‐tolerated drugs. Cilengitide (EMD 121974), a novel cyclic inhibitor of alpha‐V integrins, has both anti‐angiogenic and direct anti‐tumor effects and is a possible alternative to TNF in ILP. In this study, rats bearing a hind limb soft tissue sarcoma underwent ILP using different combinations of melphalan, TNF and cilengitide in the perfusate. Further groups had intra‐peritoneal (i.p.) injections of cilengitide or saline 2 hr before and 3 hr after ILP. A 77% response rate (RR) was seen in animals treated i.p. with cilengitide and perfused with melphalan plus cilengitide. The RR was 85% in animals treated i.p. with cilengitide and ILP using melphalan plus both TNF and cilengitide. Both RRs were significantly greater than those seen with melphalan or cilengitide alone. Histopathology showed that high RRs were accompanied by disruption of tumor vascular endothelium and tumor necrosis. Compared with ILP using melphalan alone, the addition of cilengitide resulted in a three to sevenfold increase in melphalan concentration in tumor but not in muscle in the perfused limb. Supportive in vitro studies indicate that cilengitide both inhibits tumor cell attachment and increases endothelial permeability. Since cilengitide has low toxicity, these data suggest the agent is a good alternative to TNF in the ILP setting.  相似文献   
9.
During the recording time of lung sound (LS) signals from the chest wall of a subject, there is always heart sound (HS) signal interfering with it. This obscures the features of lung sound signals and creates confusion on pathological states, if any, of the lungs. A novel method based on empirical mode decomposition (EMD) technique is proposed in this paper for reducing the undesired heart sound interference from the desired lung sound signals. In this, the mixed signal is split into several components. Some of these components contain larger proportions of interfering signals like heart sound, environmental noise etc. and are filtered out. Experiments have been conducted on simulated and real-time recorded mixed signals of heart sound and lung sound. The proposed method is found to be superior in terms of time domain, frequency domain, and time–frequency domain representations and also in listening test performed by pulmonologist.  相似文献   
10.
The objective of this study was to evaluate the effect of Emdogain (Enamel Matrix Derivative, EMD) and Bone Morphogenetic Protein-2 (BMP-2), either solely or in combination, on the gene expression and mineralized nodule formation of alveolar bone proper-derived stem/progenitor cells.Stem/progenitor cells were isolated from human alveolar bone proper, magnetically sorted using STRO-1 antibodies, characterized flowcytometrically for their surface markers' expression, and examined for colony formation and multilineage differentiation potential. Subsequently, cells were treated over three weeks with 100 μg/ml Emdogain (EMD-Group), or 100 ng/ml BMP-2 (BMP-Group), or a combination of 100 ng/ml BMP-2 and 100 μg/ml Emdogain (BMP/EMD-Group). Unstimulated stem/progenitor cells (MACS+-Group) and osteoblasts (OB-Group) served as controls. Osteogenic gene expression was analyzed using RTq-PCR after 1, 2 and 3 weeks (N = 3/group). Mineralized nodule formation was evaluated by Alizarin-Red staining.BMP and EMD up-regulated the osteogenic gene expression. The BMP Group showed significantly higher expression of Collagen-I, III, and V, Alkaline phosphatase and Osteonectin compared to MACS+- and OB-Group (p < 0.05; Two-way ANOVA/Bonferroni) with no mineralized nodule formation.Under in-vitro conditions, Emdogain and BMP-2 up-regulate the osteogenic gene expression of stem/progenitor cells. The combination of BMP-2 and Emdogain showed no additive effect and would not be recommended for a combined clinical stimulation.  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号