3.0T MR 3D-COSMIC成像序列结合MRP对Ⅰ-Ⅻ对脑神经脑池段的成像研究

目的探讨3.0TMR3D-COSMIC成像序列对Ⅰ-Ⅻ对脑神经脑池段显示的临床价值。方法采用3.0TMR扫描仪对20例健康志愿者和10例疑因血管等原因压迫相应颅脑神经产生临床症状的患者进行MR检查。并由两名神经放射学医师根据20例志愿者480支颅神经显示的清晰程度分为以下3个等级:清晰、较清晰、不清晰,前两者定义为显示,后者定义为未显示,而神经与血管的关系分为无接触、接触、压迫。结果脑神经在3D-COSMIC序列的显示率分别为:嗅神经(86%),视神经(100%),动眼神经(97%),滑车神经(23%),三叉神经(100%),外展神经(90%),面神经(100%),前庭蜗神经(100%),后组颅神经复合体(舌咽神经、迷走神经、副神经)(63%、100%、53%),舌下神经(40%)。10神经症状患者3例显示神经与周围血管接触或压迫,且均为神经外科手术证实。结论 3D-COSMIC成像序列可以较为清晰显示除滑车神经之外12对脑神经脑池段形态、走形及其与血管的关系,尤其能很好显示Ⅱ、Ⅲ、Ⅴ、Ⅵ、Ⅶ、Ⅷ、Ⅹ7对脑神经脑池段,为临床诊治提供更大的指导作用。     

功能规模度量统一模型

功能规模度量(Functional Size Measurement,FSM)方法是软件度量的一个重要研究方向。度量组织为了满足不同用户的需求,可以使用FSM的不同方法来度量软件的规模。为了能够同时运用FSM的多种方法进行度量,通过分析FSM的3种常用方法（IFPUG FPA、COSMIC FFP和MarkII FPA）,提出了功能规模度量统一模型（Unified Model of Functional Size Measurement,FSMUM）,并给出了FSMUM到FSM的3种常用方法的映射规则,最后给出了一个FSMUM的应用实例。     

Oncogenomic portals for the visualization and analysis of genome-wide cancer data

Somatically acquired genomic alterations that drive oncogenic cellular processes are of great scientific and clinical interest. Since the initiation of large-scale cancer genomic projects (e.g., the Cancer Genome Project, The Cancer Genome Atlas, and the International Cancer Genome Consortium cancer genome projects), a number of web-based portals have been created to facilitate access to multidimensional oncogenomic data and assist with the interpretation of the data. The portals provide the visualization of small-size mutations, copy number variations, methylation, and gene/protein expression data that can be correlated with the available clinical, epidemiological, and molecular features. Additionally, the portals enable to analyze the gathered data with the use of various user-friendly statistical tools. Herein, we present a highly illustrated review of seven portals, i.e., Tumorscape, UCSC Cancer Genomics Browser, ICGC Data Portal, COSMIC, cBioPortal, IntOGen, and BioProfiling.de. All of the selected portals are user-friendly and can be exploited by scientists from different cancer-associated fields, including those without bioinformatics background. It is expected that the use of the portals will contribute to a better understanding of cancer molecular etiology and will ultimately accelerate the translation of genomic knowledge into clinical practice.     

Assessment of the cervical spine denticulate ligament using MRI volumetric sequence: Comparison between 1.5 Tesla and 3.0 Tesla

Background

Denticulate ligaments (DLs) are pial extensions on each side of the spinal cord, comprising about 20 to 21 pairs of fibrous structures connecting the dura mater to the spinal cord. These ligaments are significant anatomical landmarks in the surgical approach to intradural structures. To our knowledge, there is no previous study on the detection of DLs using MRI.

3.0T MR 3D-COSMIC序列结合多平面重建对12对脑神经脑池段的成像价值

目的探讨3.0T MR 3D-COSMIC成像序列对Ⅰ～Ⅻ对脑神经脑池段显示的临床价值。方法采用3.0T MR扫描仪对20例健康志愿者和10例疑因血管等原因压迫相应颅脑神经产生临床症状的患者进行MR检查,扫描序列包括3D-COS-MIC及3D-TOF-SPGR。并由2名神经放射学医师根据20例健康志愿者480支颅神经显示的清晰程度分为清晰、较清晰、不清晰3个等级,清晰和较清晰定义为显示,不清晰定义为未显示,而神经与血管的关系分为无接触、接触、压迫。结果脑神经在3D-COSMIC序列的显示率分别为:嗅神经(86%),视神经(100%),动眼神经(97%),滑车神经(23%),三叉神经(100%),外展神经(90%),面神经(100%),前庭蜗神经(100%),后组颅神经复合体[舌咽神经(63%)、迷走神经(100%)、副神经(53%)、舌下神经(40%)]。10例神经症状患者3例显示神经与周围血管接触或压迫,且均为神经外科手术证实。结论 3D-COSMIC成像序列可以较为清晰显示除滑车神经之外12对脑神经脑池段形态、走行及其与血管的关系,尤其能很好显示Ⅱ、Ⅲ、Ⅴ、Ⅵ、Ⅶ、Ⅷ、Ⅹ共7对脑神经脑池段,为临床诊治提供更大的指导作用。     

Epithelial RNase H2 Maintains Genome Integrity and Prevents Intestinal Tumorigenesis in Mice

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MRI depiction and 3D visualization of three anterior cruciate ligament bundles

The anterior cruciate ligament (ACL) is divided into three fiber bundles (AM‐M: anteromedial‐medial, AM‐L: anteromedial‐lateral, PL: posterolateral). We attempted to depict the three bundles of the human ACL on MRI images and to obtain 3‐dimensional visualization of them. Twenty‐four knees of healthy volunteers (14 males, 10 females) were scanned by 3T‐MRI using the fat suppression 3D coherent oscillatory state acquisition for the manipulation of imaging contrast (FS 3D‐COSMIC). The scanned images were reconstructed after the isotropic voxel data, which allows the images to be reconstructed in any plane, was acquired. We conducted statistical examination on the identification rate of the three ACL bundles by 2D planes. Segmentation and 3D visualization of the fiber bundles using volume rendering were performed. The triple‐bundle ACL was best depicted in the oblique axial plane. While the AM‐M and AM‐L bundles were clearly depicted in all cases, the PL bundle was not clearly visualized in two knees (8%). Therefore, the three ACL bundles were depicted in 22 knees (92%). The results of 3D visualization of the fiber arrangement agreed well with macroscopic findings of previous anatomical studies. 3T‐MRI and the isotropic voxel data from FS 3D‐COSMIC made it possible to demonstrate the identifiable depiction of three ACL bundles in nearly all cases. 3D visualization of the bundles could be a useful tool to understand the ACL fiber arrangement. Clin. Anat. 30:276–283, 2017. 2016 The Authors. Clinical Anatomy published by Wiley Periodicals, Inc. on behalf of American Association of Clinical Anatomists.