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1.
Summary Thirty-four rats were killed by transcardial perfusion fixation 1 min after a contusing concussive head injury, and 17 rats 1 day later. From the results obtained with a new silver method demonstrating traumatically damaged neuronal somata, dendrites and axons the following conclusions were drawn: (1) outside the contused territories all features of traumatically induced neuronal argyrophilia are similar to those found in non-contusing concussive head injury, as reported in an accompanying paper; (2) within contused territories the neuronal argyrophilia is abolished by some substance released either from damaged blood vessels or from damaged parenchymal cells, while the neuronal damage otherwise underlying the induction of argyrophilia is present; (3) different phenotypes of neurons are vulnerable to different values of the parameters of the intracranial pressure wave generated by the trauma; (4) some of the neurons may recover from the traumatically induced argyrophilic damage; (5) traumatically induced inundation of neurons with extracellular tracers, as reported by other authors, and somato-dendritic argyrophilia may be different manifestations of one and the same phenomenon; and (6) diffuse primary traumatic axonal injury in human neuropathology may be closely correlated to axonal argyrophilia. 相似文献
2.
Kallakuri S Cavanaugh JM Ozaktay AC Takebayashi T 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》2003,148(4):419-424
Diffuse axonal injury (DAI) is seen as widespread damage in the white matter of brain characterized by morphological changes
to axons throughout the brain and brain stem. The current study attempted to investigate the effect of increasing impact energy
on the presence and severity of DAI in corpus callosum (CC). DAI was induced in adult male Sprague-Dawley rats using an injury
model adapted from Marmarou et al. in 1994. A 450-g cylindrical brass weight was dropped from three different heights (2.0 m,
1.5 m and 1.0 m) on to a metal helmet affixed to the skull of the rats. In the sham group, rats underwent a surgical procedure
with no impact. After a 24-h survival period the animals were transcardially perfused. The brain was removed and the cerebral
hemispheres were sectioned with a vibrotome and stained by silver impregnation technique. The CC of all the impacted rats
showed DAI in the form of beaded axons, retraction balls and vacuole-like enlargements. The axonal injury was most severe
in the 2-m group, while mildest in the 1-m group. In the sham group, axons appeared to be normal. This study demonstrates
evidence of graded DAI depending on the impact energy. Such data is useful for mathematical modeling of axonal injury in rat
brain using the same impact parameters and potential determination of injury thresholds for neural trauma.
Electronic Publication 相似文献
3.
R. G. Simon M. Gill N. Lemkey-Johnston L. M. H. Larramendi 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1971,13(5):504-513
Summary Three distinct phospholipid patterns occurred in the mitochondrial subcellular fractions: a) myelin, b) axonal-synaptosomal and c) mitochondrial. Axonal and synaptosomal fractions were found to be very similar in phospholipid and cholesterol composition. In all submitochondrial fractions cholesterol, phosphatidyl serine and sphingomyelin occurred in the relatively constant molar ratio of 1.00.180.11. The phospholipid patterns reported in this paper correspond well to others published for synaptosomes and synaptic membranes from mammalian sources as well as axonal membranes from invertebrate sources. However, morphological analysis has indicated that axonal as well as synaptosomal fractions contained significant amounts of microsomes and abundant membranes of undetermined origin which must also be considered when attempting morphological-biochemical correlations. Attention was given to the possible functional and chemical similarity of axonal and synaptosomal membranes other than that portion presumably specialized for chemical transmission, and to the difficulty of establishing the lipid pattern of the true synaptic membrane in presently available preparations. 相似文献
4.
Changes in membrane potential and potassium concentration in the extracellular space ([K+]e) of rabbit vagus nerve were measured simultaneously during electrical activity and during the period of recovery using a
modified sucrose-gap method and potassium-sensitive microelectrodes. After stimulation for 15 s at 15 Hz the main activity-induced
increase in [K+]e reached 16.9 mM. This increase in [K+]e was paralleled by a depolarization of the preparation. The period of activity was followed by a post-tetanic hyperpolarization
(PTH) lasting tens of seconds, generated by the axonal electrogenic Na+-K+ pump and to a lesser extent by the pump of the surrounding Schwann cells. The amplitude of the PTH dramatically increased
in experiments in which inward currents were blocked by removal of Cl– or after application of Cs+ or Ba2+, indicating that under normal conditions the current generated by the Na+-K+ pump is strongly short-circuited. A pharmacological and kinetic study showed that these currents are: (1) the hyperpolarization-activated
current I
h, and (2) the inwardly rectifying I
KIR current. The results show that the latter originates from Schwann cells. Our data indicate that in non-myelinated nerves
there is a subtle association of inward ionic channels which (1) helps the cell to maintain an optimal membrane potential
after a period of activity, and (2) contributes to the removal of excess K+ from the extracellular space.
Received: 7 August 1997 / Received after revision 6 April 1998 / Accepted: 15 April 1998 相似文献
5.
Cadherins in the central nervous system 总被引:9,自引:0,他引:9
Redies C 《Progress in neurobiology》2000,61(6):611-648
The central nervous system (CNS) is divided into diverse embryological and functional compartments. The early embryonic CNS consists of a series of transverse subdivisions (neuromeres) and longitudinal domains. These embryonic subdivisions represent histogenetic fields in which neurons are born and aggregate in distinct cell groups (brain nuclei and layers). Different subsets of these aggregates become selectively connected by nerve fiber tracts and, finally, by synapses, thus forming the neural circuits of the functional systems in the CNS. Recent work has shown that 30 or more members of the cadherin family of morphoregulatory molecules are differentially expressed in the developing and mature brain at almost all stages of development. In a regionally specific fashion, most cadherins studied to date are expressed by the embryonic subdivisions of the early embryonic brain, by developing brain nuclei, cortical layers and regions, and by fiber tracts, neural circuits and synapses. Each cadherin shows a unique expression pattern that is distinct from that of other cadherins. Experimental evidence suggests that cadherins contribute to CNS regionalization, morphogenesis and fiber tract formation, possibly by conferring preferentially homotypic adhesiveness (or other types of interactions) between the diverse structural elements of the CNS. Cadherin-mediated adhesive specificity may thus provide a molecular code for early embryonic CNS regionalization as well as for the development and maintenance of functional structures in the CNS, from embryonic subdivisions to brain nuclei, cortical layers and neural circuits, down to the level of individual synapses. 相似文献
6.
7.
Xiao-Lin Liu Takeru Arai Marianne Sondell Göran Lundborg Martin Kanje Lars B. Dahlin 《Journal of plastic surgery and hand surgery》2013,47(4):337-345
Nerve regeneration, measured as axonal outgrowth, Schwann cell migration, macrophage invasion, and neovascularisation, was compared after repair of a 15 mm gap in rats' sciatic nerves using autologous muscle grafts made acellular either by freezing and thawing or by chemical extraction. Both extracted and freeze-thawed acellular muscle grafts could be used to bridge the defect. However, axons and Schwann cells, as shown by immunohistochemical staining for neurofilaments and S-100 protein, respectively, grew faster into the extracted muscle grafts than into the freeze-thawed acellular muscle grafts and somewhat more axons were observed in the former graft. There were no significant differences between the two graft types with respect to neovascularisation as showed by staining for endothelial alkaline phosphatase, and limited differences concerning invasion of macrophages (ED1 and ED2) as detected by immunocytochemistry. The results showed that chemically extracted muscle grafts could be used to bridge an extended nerve defect and that such grafts in some aspects were superior to freeze-thawed muscle grafts for extended gaps. 相似文献
8.
9.
Summary Following left lateral funiculotomy, axons of cat pericruciate cortex exhibited neurofilamentous hyperplasia and complex, adaxonal, oligodendrocytic invaginations into electron-lucent or (commonly) electron-dense, degenerating axoplasm. These changes were absent from sham-operated and unoperated animals. Neurofilamentous hyperplasia was exclusively right-sided and appeared in myelinated axons 5–49 days postoperatively and in nonmyelinated axons 14–153 days after surgery. Oligoglial invaginations were present 1–49 days after surgery and were predominantly right-sided.Intramyelinic, axo-dendritic synapses appeared in operated cats 5–10 days postoperatively. Intra-axonal accumulations of ribosomes were found also. These changes also occurred exclusively or predominantly contralateral to spinal surgery.Other ultrastructural abnormalities, e.g., amorphous transformation of axoplasm and accumulations of dense bodies in intra-myelinic, dark cytoplasm, had a less certain relationship to lateral funiculotomy.The axonal alterations that were limited to operated cats possibly represent a true retrograde axonal degeneration occurring at a distance from the site of axonic interruption and unaccompanied by evidence of nerve cell death.This work was supported by the Medical Research Service of the Veterans Administration and by the National Institutes of Health Research Grant NS-08735 相似文献
10.
Summary A 21/2 year old girl who, since the age of 1 year presented, a progressive psychomotor retardation. A cortical biopsy appeared normal by light microscopy, but by electron microscopy an abundance of dilated spheroid-like axons were found. They contained either vesiculo-tubular material or densly packed filamentous material. Synapses were demonstrated between the spheroids and other neuronal bodies or dendrites. Crystalline like material was observed within mitochondria and the spheroids. It is suggested that Neuroaxonal dystrophy may be diagnosed by cortical brain biopsy.
Zusammenfassung Ein 21/2 Jahre altes arabisches Mädchen (Eltern Cousins 2. Grades) bot seit dem 1. Lebensjahr progressive psychomotorische Retardierung. Eine Hirnrindenbiopsie ergab normale lichtoptische Verhältnisse, während elektronenoptisch reichlich schollenartige Axonauftreibungen gefunden wurden. Ihr Inhalt setzte sich aus vesico-tubulärem Material oder aus dicht gepacktem filamentösen Material zusammen. Synapsen waren zwischen den Sphäroiden und anderen neuronalen Somata sowie Dendriten nachweisbar. In den Mitochondrien und Sphäroiden fanden sich kristalline Strukturen. Es wird vermutet, daß die neuroaxonale Dystrophie durch Rindenbiopsie diagnostiziert werden kann.相似文献