全文获取类型
收费全文 | 642篇 |
免费 | 19篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 6篇 |
妇产科学 | 2篇 |
基础医学 | 78篇 |
口腔科学 | 16篇 |
临床医学 | 46篇 |
内科学 | 236篇 |
神经病学 | 110篇 |
特种医学 | 7篇 |
外科学 | 47篇 |
综合类 | 15篇 |
预防医学 | 15篇 |
眼科学 | 1篇 |
药学 | 50篇 |
中国医学 | 11篇 |
肿瘤学 | 22篇 |
出版年
2023年 | 6篇 |
2022年 | 15篇 |
2021年 | 29篇 |
2020年 | 17篇 |
2019年 | 58篇 |
2018年 | 61篇 |
2017年 | 24篇 |
2016年 | 15篇 |
2015年 | 13篇 |
2014年 | 72篇 |
2013年 | 40篇 |
2012年 | 50篇 |
2011年 | 51篇 |
2010年 | 46篇 |
2009年 | 25篇 |
2008年 | 43篇 |
2007年 | 30篇 |
2006年 | 11篇 |
2005年 | 14篇 |
2004年 | 7篇 |
2003年 | 5篇 |
2002年 | 5篇 |
2001年 | 3篇 |
2000年 | 4篇 |
1998年 | 2篇 |
1997年 | 3篇 |
1996年 | 2篇 |
1994年 | 1篇 |
1991年 | 2篇 |
1988年 | 1篇 |
1985年 | 5篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1982年 | 1篇 |
1979年 | 1篇 |
排序方式: 共有664条查询结果,搜索用时 171 毫秒
1.
《The British journal of oral & maxillofacial surgery》2019,57(8):716-721
Adenoid cystic carcinoma (ACC) is an aggressive, rare, malignant tumour that accounts for about 1% of all head and neck neoplasms and 10% of all salivary gland tumours. It is characterised by frequent local recurrences and distant metastases. Growth is slow but relentless, and progression poses a challenge to head and neck clinicians. Many small retrospective studies have described its clinical management, but the lack of multicentre, randomised, controlled trials has resulted in inconsistencies in management globally. We have focused on three key management-related controversies: the role of elective neck dissection (END) for the N0 neck; the role of adjuvant treatment or radiotherapy; and finally, the follow-up protocol, particularly cross-sectional surveillance imaging of the full body or chest computed tomography (CT) alone, and options for treatment if metastases are found. The paucity of published studies may reflect the inconsistencies that exist in the management of ACC of the head and neck in the UK. The collaboration of head and neck centres would, we think, help to correct the imbalance in these three domains of care. 相似文献
2.
Karen K. Stout Curt J. Daniels Jamil A. Aboulhosn Biykem Bozkurt Craig S. Broberg Jack M. Colman Stephen R. Crumb Joseph A. Dearani Stephanie Fuller Michelle Gurvitz Paul Khairy Michael J. Landzberg Arwa Saidi Anne Marie Valente George F. Van Hare 《Journal of the American College of Cardiology》2019,73(12):e81-e192
3.
Javed Butler Mei Yang Massimiliano Alfonzo Manzi Gregory P. Hess Mahesh J. Patel Thomas Rhodes Michael M. Givertz 《Journal of the American College of Cardiology》2019,73(8):935-944
Background
Epidemiology of patients with worsening heart failure and reduced ejection fraction (HFrEF) in the real-world setting is not well described.Objectives
The purpose of this study was to describe incidence, clinical characteristics, treatment, and outcomes of patients with HFrEF who develop worsening heart failure (HF) in the real-world setting.Methods
Data on patients with incident HFrEF from the National Cardiovascular Data Registry PINNACLE were linked to pharmacy, private practitioner, and hospital claims databases. Incidence, clinical characteristics, treatment (angiotensin-converting enzyme inhibitor/angiotensin receptor blocker, beta-blocker, and mineralocorticoid receptor antagonist) and outcomes of patients with worsening HF, defined as ≥90 days of stable HF with subsequent worsening requiring intravenous diuretic agents, were assessed.Results
Of 11,064 HFrEF patients, 1,851 (17%) developed worsening HF on average 1.5 years following initial HF diagnosis. Patients who developed worsening HF were more likely to be African American, be octogenarians, and have higher comorbidity burden (p < 0.001). At the onset of worsening HF, 42.4% of patients were on monotherapy, 43.4% were on dual therapy, and 14.1% were on triple therapy. A total of 48%, 61%, and 98% of patients were on >50% target dose for angiotensin-converting enzyme inhibitor/angiotensin receptor blocker, beta-blocker, and mineralocorticoid receptor antagonist, respectively. The 2-year mortality rate was 22.5%, and 56% of patients were rehospitalized within 30 days of the worsening HF event.Conclusions
In the real-world setting, 1 in 6 patients with HFrEF develop worsening HF within 18 months of HF diagnosis. These patients have a high risk for 2-year mortality and recurrent HF hospitalizations. The use of standard-of-care therapies both before and after the onset of worsening HF is low. With high unmet medical need, patients with worsening HF require novel treatment strategies as well as greater optimization of existing guideline-directed therapy. 相似文献4.
Sai Li Xiaoming Jiang Hongbo Yu Xiaolin Zhou 《Social cognitive and affective neuroscience》2014,9(8):1166-1174
Previous studies have shown that brain regions for mentalizing, including temporoparietal junction (TPJ) and medial prefrontal cortex (mPFC), are activated in understanding the nonliteral meaning of sentences. A different set of brain regions, including left inferior frontal gyrus (IFG), is activated for dealing with pragmatic incongruence. Here we demonstrate that individuals’ cognitive empathic ability modulates the brain activity underlying the processing of pragmatic constraints during sentence comprehension. The lian … dou … construction in Chinese (similar to English even) normally describes an event of low expectedness; it also introduces a pragmatic scale against which the likelihood of an underspecified event can be inferred. By embedding neutral or highly likely events in the construction, we created underspecified and incongruent sentences and compared both with control sentences in which events of low expectedness were described. Imaging results showed that (i) left TPJ was activated for the underspecified sentences, and the activity in mPFC correlated with individuals’ fantasizing ability and (ii) anterior cingulate cortex (ACC) was activated for the incongruent sentences, and the activity in bilateral IFG correlated with individuals’ perspective taking ability. These findings suggest that brain activations in making pragmatic inference and in dealing with pragmatic failure are modulated by different components of cognitive empathy. 相似文献
5.
Fenton H. McCarthy Sreekanth Vemulapalli Zhuokai Li Vinod Thourani Roland A. Matsouaka Nimesh D. Desai Ajay Kirtane Saif Anwaruddin Matthew L. Williams Jay Giri Prashanth Vallabhajosyula Robert H. Li Howard C. Herrmann Joseph E. Bavaria Wilson Y. Szeto 《The Annals of thoracic surgery》2018,105(4):1121-1128
6.
7.
Rakesh M. Suri Brian C. Gulack J. Matthew Brennan Vinod H. Thourani Dadi Dai Alan Zajarias Kevin L. Greason Christina M. Vassileva Verghese Mathew Vuyisile T. Nkomo Michael J. Mack Charanjit S. Rihal Lars G. Svensson Rick A. Nishimura Patrick T. O’Gara David R. Holmes Jr. 《The Annals of thoracic surgery》2015,100(6):2136-2146
8.
9.
10.
《Heart rhythm》2019,16(8):e66-e93