阿昔洛韦三种给药途径治疗单疱病毒性角膜炎疗效比较

目的：观察应用阿昔洛韦（ＡＣＶ）的三种给药方式治疗单疱病毒性角膜炎（ＨＳＫ）的疗效和复发率。方法：采用随机分组方法将１１７例、１５４眼ＨＳＫ分为４组进行对照研究。结果：治愈率各组间无显著性差异（Ｐ＞００５）。治愈时间ＡＣＶ组明显短于对照组（Ｐ＜００１）。ＡＣＶ组复发率亦低于对照组（Ｐ＜００５）。结论：ＡＣＶ治疗ＨＳＫ效果好、疗程短、复发率低,综合用药疗效更佳,抗单纯疱疹病毒Ⅰ型的能力强于病毒唑。     

微量皮质类固醇联合抗病毒药物治疗单纯疱疹病毒性角膜炎

目的观察微量皮质类固醇与抗病毒药物合用对单纯疱疹病毒性角膜炎（ＨＳＫ）的疗效。方法将１６０例ＨＳＫ患者随机分为治疗组和对照组,治疗组用５ｇ·Ｌ－１可的松、１ｇ·Ｌ－１无环鸟苷（ＡＣＶ）和２５ｇ·Ｌ－１三氮唑核苷（ＲＢＶ）３种眼液,对照组用１ｇ·Ｌ－１ＡＣＶ和２５ｇ·Ｌ－１ＲＢＶ２种眼液交替滴眼治疗。结果治疗组治愈率、有效率明显高于对照组（Ｐ＜０．０１）,治愈时间明显短于对照组（Ｐ＜０．０１）,随访１４～２４ｍｏ复发率明显低于对照组（Ｐ＜０．０１）。结论在临床上用微量皮质类固醇联合足量有效的抗病毒药物,对上皮型和实质层型ＨＳＫ都能促进其痊愈过程,并可降低复发率。     

角膜胶原膜的研制及临床应用

目的研究角膜胶原膜的制做方法及其在单纯疱疹病毒性角膜炎(HSK)治疗中的应用。方法从猪巩膜中提取胶原采用离心干燥成膜法制成角膜胶原膜 ,在无环鸟苷药液内浸泡后用治疗单纯疱疹病毒性角膜炎。结果应用浸泡无环鸟苷(ACV)药液的胶原膜治疗组病灶平均愈合时间9 45天 ,局部滴无环鸟苷药液组病灶愈合平均时间14 36天 ,两组治愈和有效率分别为90 63 % ,65 63 %和96 88 % ,81 25 %差异具有显著性(P<0.05)。结论浸泡无环鸟苷药液后的胶原膜在单纯疱疹病毒性角膜炎的治疗中将具有较好的应用前景     

中药治疗聚星障临床观察

目的：观察中药对聚星障的效果。方法：对８０例聚星障患者分炽药治疗组５０例（５５只眼）和对照组３０例。中药治疗组用辨证分型论治,口服黑睛１－４号方,局部用银胆滴眼液。对照组用无环鸟苷滴眼液和羟苄唑滴眼液,口服病毒灵两组患者接受治疗和观察的时间相同。结果：中药治疗组有效率为９６．４％,对照组有效率８７．１％。结论：中药治疗聚星障有更好的效果。     

Interaction of Angiogenic and Immune Mechanisms in the Eye

Although a critical physiologic process, angiogenesis also contributes to the pathology associated with a variety of ocular diseases. Here we describe immune factors that regulate angiogenesis and review recent attempts to exploit these factors in animal models of ocular disease.     

HSK向MHK边渡的教学重点探析

1996年教育部民族教育司在新疆乌鲁木齐召开了全国少数民族汉语教学研讨会。会上介绍了主要面向外国人的中国汉语水平考试（HSK）在考查汉语水平方面的一些经验,之后HSK在新疆等少数民族聚居地开始进行试点。经过十几年的探索,发现HSK的试行对少数民族地区的汉语教学产生了非常积极的影响,促进了汉语教学模式的转变,即从原来的“教材翻译”模式向“交际模式”转化,从注重知识向注重能力转化,它的推广使少数民族学生走上了注重对交际能力培养的道路。     

中西医结合治疗单纯疱疹病毒性角膜炎64例

目的:观察中西医结合治疗单纯疱疹病毒性角膜炎的临床疗效.方法:选取单纯疱疹病毒性角膜炎患者128例,随机分为观察组和对照组,每组64例.对照组应用0.1％阿昔洛韦滴眼液与0.1％羟苄唑眼液交替滴眼治疗,对于深层角膜炎患者,阿昔洛韦0.5g加至0.9％葡萄糖注射液500 mL中静脉滴注;观察组在对照组治疗的基础上加服中药治疗.结果:观察组有效率为95.59％,对照组有效率为78.26％,观察组显著优于对照组(P＜0.01);观察组平均治愈时间、复发率均优于对照组(P均＜0.05).结论:中西医结合治疗单纯疱疹病毒性角膜炎疗效显著.     

Dynamic Expression of Chemokines and the Infiltration of Inflammatory Cells in the HSV-Infected Cornea and its Associated Tissues

Background: The chemotactic signals regulating cell trafficking in the herpes simplex virus type 1 (HSV-1) infected cornea are well documented, however, those in the cornea-associated tissues, such as the trigeminal ganglion (TG) and draining lymph nodes (LNs), are largely unknown. Objectives: To examine chemokine expression and subsequent cell infiltration in the HSV-1 infected cornea and its associated tissues. Study design: Eight-week-old female BALB/c mice were infected with 10 μ l HSV-1 (CHR3 strain: 5 × 10⁶ PFU/ml) by corneal scarification. Total RNAs were extracted from the corneas, TGs, and LNs at pre-inoculation, 3 days post-inoculation (P.I.) and 7 days P.I. The mRNA for 28 different chemokines in the extracts was amplified by RT-PCR. Infiltrating cells were identified by immunohistochemistry. Result: After the HSV-1 infection, the corneal stroma became edematous by infiltrated cells under the eroded epithelium. The TG and LNs were markedly swollen. The cornea was infiltrated with granulocytes and CD11b⁺ cells at 3 days P.I., followed by CD4⁺ and CD8⁺ T cells at 12 days P.I. In the TG, CD11b⁺ cells, but no granulocytes, infiltrated throughout the observation period. T cells migrated into the TG earlier than into the cornea. Gene expressions of neutrophil-attracting chemokines (CXCL1, 2, 3, and 5) increased in the cornea, but they did not enhance in the TG or LNs. On the other hand, gene expressions of chemokines which attract CD11b⁺ cells such as CCL2, 8, 7, 12, CCL3, 4, and CCL5, increased in the cornea and TG with its peak at 3 days P.I. Gene expressions of chemokines those work on T cells and B cells, such as CCL19, CCL21, CXCL9, CXCL13, CXCL10, XCL1, and CXCL16, were up-regulated and peaked at 3 days P.I. in the cornea and in the TG. Thus, pattern of chemokine gene expression was similar in the cornea and in the TG. On the contrary, gene expressions of chemokines in the draining LNs affecting CD11b⁺ cells and T cells were temporarily down-regulated. Conclusion: Upon HSV-1 infection, dynamic gene expression of chemokines was observed not only in the inoculated cornea but also in its associated tissues.     

中西医结合治疗单纯疱疹病毒性角膜炎的护理

目的观察中西医结合治疗单纯疱疹病毒性角膜炎的效果及相关护理方法。方法按随机数字表法将179例(186只病眼)单纯疱疹病毒性角膜炎患者分为治疗组93例(97只病眼),予以中医辨证分型治疗、中药超声雾化浴眼,并配合西药抗病毒治疗;对照组86例(89只病眼),予以抗病毒药物静脉滴注治疗。结果经精心治疗与护理,治疗组93例患者97只病眼中,显效65只眼、有效25只眼、无效7只眼;对照组86例患者89只病眼,显效49只眼,有效24只眼,无效16只眼,两组比较,差异有统计学意义(P<0.05)。结论中西医结合治疗单纯疱疹病毒性角膜炎具有病程短、复发率低、疗效好、视力恢复快等优点。     

应用PCR技术诊断单疱病毒性角膜炎

目的 探讨ＰＣＲ对ＨＳＫ的诊断价值。方法 应用ＰＣＲ技术对临床诊断活动期ＨＳＫ８８眼匐行性角膜溃疡５眼,原因不明角膜炎５眼进行ＨＳＶ－１ＤＮＡ检测。结果 活动期ＨＳＫ具有上皮病变者３０眼中２４眼检出ＨＳＶ－１ＤＮＡ,５眼匐形性角膜溃疡全部未检出ＨＳＶ－１ＤＮＡ;５眼原因不明角膜炎中１眼检出ＨＳＶ－１ＤＮＡ。结论 ＰＣＲ是一种快速、灵敏、特异性强的方法,对胸膜炎的早期诊断及鉴别诊断具有重要意义,具有