全文获取类型
收费全文 | 151篇 |
免费 | 25篇 |
国内免费 | 3篇 |
专业分类
基础医学 | 6篇 |
临床医学 | 6篇 |
内科学 | 10篇 |
皮肤病学 | 5篇 |
外科学 | 2篇 |
综合类 | 11篇 |
药学 | 122篇 |
中国医学 | 4篇 |
肿瘤学 | 13篇 |
出版年
2023年 | 2篇 |
2022年 | 3篇 |
2021年 | 5篇 |
2020年 | 6篇 |
2019年 | 11篇 |
2018年 | 12篇 |
2017年 | 9篇 |
2016年 | 8篇 |
2015年 | 12篇 |
2014年 | 7篇 |
2013年 | 20篇 |
2012年 | 10篇 |
2011年 | 13篇 |
2010年 | 8篇 |
2009年 | 7篇 |
2008年 | 7篇 |
2007年 | 6篇 |
2006年 | 7篇 |
2005年 | 2篇 |
2004年 | 3篇 |
2003年 | 4篇 |
2002年 | 1篇 |
2001年 | 5篇 |
1999年 | 2篇 |
1998年 | 4篇 |
1997年 | 1篇 |
1994年 | 1篇 |
1989年 | 2篇 |
1983年 | 1篇 |
排序方式: 共有179条查询结果,搜索用时 0 毫秒
1.
抗真菌剂三氮唑含硫化合物的合成 总被引:3,自引:0,他引:3
合成了13个三氮唑含硫化合物,均为未见文献报道的新化合物,对所合成的化合物,选择三种常见真菌进行体外最低抑菌浓度(MIC)的测定,结果表明它们均有较好的抗真菌活性,有些化合物抑菌活性极高,有进一步研究和开发前景。 相似文献
2.
叔丁基三唑衍生物的合成及抗真菌活性研究 总被引:4,自引:4,他引:4
目的研究具有叔丁基结构的三唑醇类化合物的抗真菌活性以及各种4-(4-烷氧基苯基)哌嗪侧链的引入对抗真菌活性的影响.方法以一氯频那酮、三氮唑为原料,经多步反应合成目标化合物,化合物结构经IR、1H-NMR谱确证;选择8种真菌为实验菌株,按国际标准抗真菌敏感性实验方法测定其体外抗真菌活性.结果设计合成了10个新化合物.10个目标化合物对8种真菌均具有一定的抑制活性,其中,有4个化合物对白色念珠菌的MIC80值小于或等于0.125 mg·L-1,是氟康唑的4倍以上,与伊曲康唑相当.结论可以通过引入更多的疏水基团设计三唑醇类化合物,立体化学因素对该类化合物的体外抑菌活性有较大影响. 相似文献
3.
The persistent deterioration of our environmental assets has initiated ‘a push’ among the scientific community for increased reliance on eco-friendly methodologies minimizing the utilization of hazardous materials. As an outcome, there is a paradigm shift in the synthetic modules of organic reactions from conventional techniques to the parameters of green principles. Therefore, the demand for microwave (μw) tailored reactions has witnessed substantial and exponential growth in the last two decades. In accordance, the employment of green methodology in Cu(I) catalyzed alkyne-azide cycloaddition reaction (CuAAC) for the synthesis of 1,2,3–triazole derivatives have reared fruitful results with the reduction of synthetic time, superior yields without benign solvents. The use of the microwave technique has been amplified with its implementation of a range of green methodologies by contributing to solvent-less, catalyst-free, use of ionic liquids and aqueous medium. This review puts forward the microwave synthesis of 1,2,3–triazoles through Cu(I) mediated click chemistry. 相似文献
4.
M. Stasevych V. Zvarych V. Lunin T. Halenova O. Savchuk O. Dudchak M. Vovk V. Novikov 《Indian journal of pharmaceutical sciences》2015,77(5):634-637
The influence of new derivatives of 9,10-anthraquinone with benzoylthiourea, thiazole, triazole and amino acid fragments on the activity of membrane-associated tyrosine kinases was investigated. Inhibitors of protein tyrosine kinase activity of the membrane fraction, as promising agents to search for new potential anticancer agents among the studied compounds, were discovered. 相似文献
5.
A novel series of N′‐(2‐(3,5‐disubstituted‐4H‐1,2,4‐triazol‐4‐yl)acetyl)‐6/7/8‐substituted‐2‐oxo‐2H‐chromen‐3‐carbohydrazides were synthesized and studied for their α‐glucosidase inhibition activity. Most of the synthesized compounds exhibited potential α‐glucosidase inhibition activity with IC50 values ranging from 0.96 ± 0.02 to 32.86 ± 0.73 µg/ml. Among them, compounds 3e and 4e , having a methoxy group on the coumarin ring, proved to be the most potent ones, showing an enzyme inhibition activity with IC50 = 0.96 ± 0.02 and 1.44 ± 0.06 µg/ml, respectively. The kinetic study through Lineweaver–Burk plots revealed that the inhibition mechanism of the most active compounds 3d, 3e, 4d , and 4e , on the α‐glucosidase activity, was found to be in the competitive mode. 相似文献
6.
Synthesis,evaluation, and molecular docking studies of aryl urea‐triazole‐based derivatives as anti‐urease agents 下载免费PDF全文
Setareh Moghimi Fereshteh Goli‐Garmroodi Maryam Allahyari‐Devin Hedieh Pilali Malihe Hassanzadeh Shabnam Mahernia Mohammad Mahdavi Loghman Firoozpour Massoud Amanlou Alireza Foroumadi 《Archiv der Pharmazie》2018,351(7)
7.
8.
《Chemical biology & drug design》2018,91(2):526-533
A series of 5‐(4‐(pyridin‐4‐yl)‐1H‐1,2,3‐triazol‐1‐yl)benzonitrile derivatives ( 1a–p ) was designed, synthesized, and identified as xanthine oxidase inhibitors with micromolar level potencies. Among them, the most promising compounds 1j and 1k were obtained with IC50 values of 8.1 and 6.7 μm , respectively. The Lineweaver–Burk plot revealed that compound 1k acted as a mixed‐type xanthine oxidase inhibitor. SAR analysis revealed that a carbon atom occupying the X3 position is not as effective as a nitrogen atom, and an iso‐pentyloxy or a cyclopentyloxy at the 2‐position of benzonitrile moiety will benefit the inhibitory potency. The basis of xanthine oxidase inhibition by 1k was rationalized by molecular modeling studies. 相似文献
9.
《Chemical biology & drug design》2018,92(1):1315-1323
In the quest for new active molecules against Mycobacterium tuberculosis, a series of dihydroquinoline derivatives possessing triazolo substituents were efficiently synthesized using click chemistry. The structure of 6l was evidenced by X‐ray crystallographic study. The newly synthesized compounds were evaluated for their in vitro antitubercular activity against Mycobacterium tuberculosis H37Rv (ATCC27294). The compounds 6a , 6g, and 6j (MIC: 3.13 μg/ml) showed promising activity when compared to the first‐line drug such as ethambutol. In addition, the structure and antitubercular activity relationship were further supported by in silico molecular docking studies of the active compounds against 3IVX.PDB (crystal structure of pantothenate synthetase in complex with 2‐(2‐(benzofuran‐2‐ylsulfonylcarbamoyl)‐5‐methoxy‐1H‐indol‐1‐yl)acetic acid). 相似文献
10.
《Chemical biology & drug design》2018,92(1):1373-1381
In this work, a wide range of novel quinazolin‐4(3H)‐one linked to 1,2,3‐triazoles was designed, synthesized, and evaluated against a panel of three human breast (MDA‐MB‐231, MCF‐7, T‐47D), lung (A549), and prostate (PC3) cancer cell lines. Our results revealed that the anticancer activity of the synthesized compounds was selectively affected by the presence of methoxy group on the linker between quinazolinone and 1,2,3‐triazole moieties. According to the calculated IC50 values, compounds 6q , 6w , and 6x showed good cytotoxicity against breast cancer cell lines even more effective than the reference drug, etoposide. Compounds 6q and 6u were found to be potent compounds against A549, non‐small‐cell lung cancer (NSCLC), comparing with erlotinib. Also, the morphological analysis by acridine orange/ethidium bromide double staining test and flow cytometry analysis indicated that potent compounds induced apoptosis in human cancer cell lines. Molecular docking studies were performed to clarify the inhibition mode of compounds 6g , 6u , 6w , and 6x over the EGFR active site. The most promising compounds, 6q and 6u , possessing 3‐methoxy group were well oriented to the gatekeeper hydrophobic pocket of EGFR active site and interact well with Ala719, Val702, and Leu820 through hydrophobic interaction. 相似文献