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目的研究纳米磷酸钙/氧化锆骨组织工程支架材料体内降解特性,为进一步构建组织工程化纳米人工骨提供研究依据。方法制作兔股部肌袋,将灭菌的纳米磷酸钙/氧化锆骨组织工程支架材料植入肌袋内,在植入4周、8周、12周、16周时取材通过大体、组织学、扫描电镜观察材料降解情况,同时将材料取出后煅烧,测量残余无机物含量,判断降解的量,同时进行X线衍射实验,测量残余材料的组成。结果材料植入8周内降解较慢,生物力学强度减低不明显,12周时降解加速,材料强度明显减低,16周时新骨形成明显,降解残余材料分布于新形成的骨组织内部,X线衍射发现12周时材料内有羟基磷灰石成分出现,提示有新骨形成,16周时羟基磷灰石成分明显增多。结论纳米磷酸钙/氧化锆骨组织工程支架材料具有较好的降解性和生物相容性,具有诱导成骨作用,可作为骨组织工程的支架材料。 相似文献
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纳米技术及其在生物医学中的应用 总被引:5,自引:0,他引:5
纳米技术和生物学相结合而形成的纳米生物学将是21世纪生命科学的重要组成部分;纳米技术和医学相结合形成的纳米医学必将大大改善医疗方法,提高治疗水平;被誉为21世纪制造技术的纳米技术将允许我们廉价地制造一些复杂的分子机器,也允许我们制造一些比细胞还要小很多的工具,利用这些工具我们可以更方便地来探究生命的奥秘。可以使医疗在细胞和分子水平上进行。也能够让我们以不可思议的细节来检查生物组织和器官。 相似文献
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本文介绍纳米技术在药学研究中的应用与发展,利用其在药物领域中不同方面的应用为线索,进行综述,为新药研制和开发提供借鉴。 相似文献
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Research strategies for safety evaluation of nanomaterials, Part I: evaluating the human health implications of exposure to nanoscale materials. 总被引:5,自引:0,他引:5
Nanotechnology has the potential to dramatically improve the effectiveness of a number of existing consumer and industrial products and could have a substantial impact on the development of new products ranging from disease diagnosis and treatment to environmental remediation. The broad range of possible nanotechnology applications could lead to substantive changes in industrial productivity, economic growth, and international trade. A continuing evaluation of the human health implications of exposure to nanoscale materials will be essential before the commercial benefits of these materials can be fully realized. The purpose of this article is to review the human health implications of exposure to nanoscale materials in the context of a toxicological risk evaluation, the current scope of U.S. Federal research on nanoscale materials, and selected toxicological studies associated with nanoscale materials to note emerging research in this area. 相似文献
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Gizem Tezel Selin Seda Timur Filiz Kuralay R. Neslihan Gürsoy Kezban Ulubayram Levent Öner 《Journal of drug targeting》2021,29(1):29-45
Abstract Synthetic micro/nanomotors (MNMs) are novel, self-propelled nano or microscale devices that are widely used in drug transport, cell stimulation and isolation, bio-imaging, diagnostic and monitoring, sensing, photocatalysis and environmental remediation. Various preparation methods and propulsion mechanisms make MNMs “tailormade” nanosystems for the intended purpose or use. As the one of the newest members of nano carriers, MNMs open a new perspective especially for rapid drug transport and gene delivery. Although there exists limited number of in-vivo studies for drug delivery purposes, existence of in-vitro supportive data strongly encourages researchers to move on in this field and benefit from the manoeuvre capability of these novel systems. In this article, we reviewed the preparation and propulsion mechanisms of nanomotors in various fields with special attention to drug delivery systems. 相似文献
7.
《Expert review of anticancer therapy》2013,13(6):833-837
Cancer nanotechnology is currently under intense development for applications in cancer imaging, molecular diagnosis and targeted therapy. The basic rationale is that nanometer-sized particles, such as biodegradable micelles, semiconductor quantum dots and iron oxide nanocrystals, have functional or structural properties that are not available from either molecular or macroscopic agents. When linked with biotargeting ligands, such as monoclonal antibodies, peptides or small molecules, these nanoparticles are used to target malignant tumors with high affinity and specificity. In the ‘mesoscopic’ size range of 5–100 nm in diameter, nanoparticles also have large surface areas and functional groups for conjugating to multiple diagnostic (e.g., optical, radioisotopic or magnetic) and therapeutic (e.g., anticancer) agents. Recent advances have led to multifunctional nanoparticle probes for molecular and cellular imaging, nanoparticle drugs for targeted therapy, and integrated nanodevices for early cancer detection and screening. These developments have opened exciting opportunities for personalized oncology in which cancer detection, diagnosis and therapy are tailored to each individual’s molecular profile, and also for predictive oncology, in which genetic/molecular information is used to predict tumor development, progression and clinical outcome. 相似文献
8.
Vinita Vishwakarma 《Journal of basic microbiology》2020,60(3):198-206
The growth of technology and requirements globally for various commodities has brought about new challenges. Biofilms are aggregations of microbial cells, which contaminate and spoil industrial components and environments. These microbial cells with extracellular polymeric substances colonize living and nonliving surfaces and pose a serious problem for all industries, affecting their processes, leading to a reduction of product quality and economic loss. Industries, such as medical, food, water, dairy, wine, marine, power plants are exposed to biofilm formation. Pipe blockages, waterlogging and reduction of the heat-transfer efficiency, hamper the operating system of plants. Many industries do not set up remedial measures to control biofilm formation as they are not aware of this threat. Various conventional methods to control these biofilms are adopted by industries in their regular workflow, but these are temporary solutions. This calls for further research into remediation of the biofilm and its control for industrial components. This review article addresses the problems of biofilms and proposes solutions for various industrial components. Nanotechnology promises several options, and bring about a new aspect into the industrial economy, by solving the problems of environmental biofilms. 相似文献
9.
《Expert review of anticancer therapy》2013,13(12):1891-1897
There has been an explosion in the development of microscopic and miniaturized technology over the past decade and we have long awaited their arrival and integration into clinical practice. We have now reached the stage where promises are beginning to be delivered. This article reviews their place in modern medicine and looks toward the future. Miniature camera robots (microrobots) provide a mobile viewing platform, enhancing a surgeon’s view. Nanorobots have arisen from the fictional world of the ‘Fantastic Voyage’ and are finally approaching clinical application. As the targeting and drive forces are further developed, these vehicles could be realistically used for delivery of agents for diagnosis and therapies. These new robots have the potential to further evolve the robotic armamentarium for surgeons. 相似文献
10.
We developed a system of Cetuximab-conjugated micelles of vitamin E TPGS for targeted delivery of docetaxel as a model anticancer drug for treatment of the triple negative breast cancer (TNBC), which shows no expression of either one of the hormone progesterone receptor (PR), estrogen receptor (ER) and epidermal growth factor receptor 2 (HER2) and is thus more difficult to be treated than the positive breast cancer. Such micelles are of desired particle size, drug loading, drug encapsulation efficiency and drug release profile. Their surface morphology, surface charge and surface chemistry were also characterized. The fibroblast cells (NIH3T3), HER2 overexpressed breast cancer cells (SK-BR-3), ER and PR overexpressed breast cancer cells (MCF7), and TNBC cells of high, moderate and low EGFR expression (MDA MB 468, MDA MB 231 and HCC38) were employed to access in vitro cellular uptake of the coumarin 6 loaded TPGS micelles and cytotoxicity of docetaxel formulated in the micelles. The high IC50 value, which is the drug concentration needed to kill 50% of the cells in a designated period such as 24 h, obtained from Taxotere® showed that the TNBC cells are indeed more resistant to the free drug than the positive breast cancer cells. However, the therapeutic effects of docetaxel could be greatly enhanced by the formulation of Cetuximab conjugated TPGS micelles, which demonstrated 205.6 and 223.8 fold higher efficiency than Taxotere® for the MDA MB 468 and MDA MB 231 cell lines respectively. 相似文献