Determination of residual Kryptofix 2.2.2 levels in [F]-labeled radiopharmaceuticals for human use

4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane (Kryptofix^® 2.2.2) is used in the routine preparation of [¹⁸F]-labeled tracers employed in positron emission tomography (PET) imaging. Confirming the absence of Kryptofix^® in radiopharmaceuticals is a quality control criterion required before they can be released for human use. Analysis of Kryptofix^® levels using the iodoplatinate spot-test can be complicated by false-positive results due to nitrogen containing tracers and/or false-negative results caused by added stabilizers. To overcome this issue, we have developed a universal TLC method for the rapid and reliable determination of Kryptofix^® levels in the wide range of fluorine-18 radiopharmaceuticals we prepare, including complex multi-component formulations.     

Drug-Resistant Tuberculosis in Pet Ring-Tailed Lemur,Madagascar

We diagnosed tuberculosis in an illegally wild-captured pet ring-tailed lemur manifesting lethargy, anorexia, and cervical lymphadenopathy. Whole-genome sequencing confirmed the Mycobacterium tuberculosis isolate belonged to lineage 3 and harbored streptomycin resistance. We recommend reverse zoonosis prevention and determination of whether lemurs are able to maintain M. tuberculosis infection.     

马克思关于人类社会阶段“跨越”发展的辩证法

马克思曾设想俄国农村公社有可能跨越资本主义制度“卡夫丁峡谷”而直接进入共产主义社会。本文运用马克思主义理论辩证地阐述了人类社会实现跨越发展所必备的条件内在因素、外在条件、动力以及跨越的内容。     

医疗机构产权制度改革及其监管

本文从产权的角度出发,对当前的医疗机构改革进行了分析,并对医疗机构自主经营、企业化经营过程中可能出现的一些问题,提出了政府作为财产的最终所有者应加强对医疗机构经营状况的监管。     

The Effect of Residential Aged Care Size,Ownership Model,and Multichain Affiliation on Resident Comfort and Symptom Management at the End of Life

Context

In most resource-rich countries, a large and growing proportion of older adults with complex needs will die while in a residential aged care (RAC) facility.

Perceptual Embodiment of Prosthetic Limbs by Transcutaneous Electrical Nerve Stimulation

Objectives: In able‐bodied participants, it is possible to induce a sense of perceptual embodiment in an artificial hand using a visual‐tactile illusion. In amputee patients, electrical stimulation of sensory afferents using transcutaneous electrical nerve stimulation (TENS) has been shown to generate somatic sensations in an amputee's phantom limb(s). However, the effects of TENS on the perceptual embodiment of an artificial limb are not known. Our objective was to investigate the effects of TENS on the perceptual embodiment of an artificial limb in fully intact able‐bodied participants. Materials and Methods: We used a modified version of the rubber hand illusion presented to 30 able‐bodied participants (16 women, 14 men) to convey TENS paresthesia to an artificial hand. TENS electrodes were located over superficial radial nerve on the lateral aspect of the right forearm (1 cm proximal to the wrist), which was hidden from view. TENS intensity was increased to a strong non‐painful TENS sensation (electrical paresthesia) was felt beneath the electrodes and projecting into the fingers of the hand. The electrical characteristics of TENS were asymmetric biphasic electrical pulsed waves, continuous pulse pattern, 120 Hz pulse frequency (rate), and 80 µs pulse duration (width). Results: Participants reported significantly higher intensities of the rubber hand illusion during the two TENS conditions (mean = 5.8, standard deviation = 1.9) compared with the two non‐TENS conditions (mean = 4.9, standard deviation = 1.7), p < 0.0005. Conclusions: Our findings provide initial evidence that TENS paresthesia can be projected into an artificial limb, and this can enhance the sense of perceptual embodiment of an artificial hand. Further exploratory studies involving an amputee population are warranted.     

The nutritive adequacy of some Nigerian peasant diets

The nutritive values of six traditional diets of the people of South‐Eastern Nigeria have been evaluated. A bioassay procedure was used; it involved the measurement of Biological Value, True Digestibility of the dietary nitrogen, Net Protein Utilization (operative) and Net Dietary Protein Calories Percent (NDpCals%). The procedures were applied to diets cooked as for human consumption, then dried and fed unmodified to male weaning albino rats. The results showed that in all cases the digestibility of the dietary nitrogen was high but the nutritive value was significantly low. These results are discussed and compared with the FAO recommended practical allowances for NDpCals% for various physiological ages and states.