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Objectives
The purpose of this review is to focus on the association of vitamin D and cardiovascular risk factors in postmenopausal women.Methods
Review of the relevant literature and results from recent clinical studies as well as critical analysis of published results concerning the association of vitamin D and cardiovascular risk factors in postmenopausal women obtained from both a PubMed and individual searches.Results and discussion
Both basic science and clinical studies support the protective role of vitamin D on cardiovascular health, although there are controversial results in the literature. Hypovitaminosis D is associated with disturbed glucose metabolism and pancreatic β-cell dysfunction, lipoprotein alterations, hypertension, overweight and obesity. The evidence highlights the importance of improving vitamin D status in the general population for the prevention of adverse long-term health risks, including cardiovascular health. The optimal vitamin D dose remains to be determined. However, correction of low vitamin D itself does not guarantee the prevention of these conditions. 相似文献2.
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Li Liu Fred K. Tabung Xuehong Zhang Jonathan A. Nowak Zhi Rong Qian Tsuyoshi Hamada Daniel Nevo Susan Bullman Kosuke Mima Keisuke Kosumi Annacarolina da Silva Mingyang Song Yin Cao Tyler S. Twombly Yan Shi Hongli Liu Mancang Gu Hideo Koh Edward L. Giovannucci 《Clinical gastroenterology and hepatology》2018,16(10):1622-1631.e3
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Etay Ziv Samuel L. Rice John Filtes Hooman Yarmohammadi F. Edward Boas Joseph P. Erinjeri Elena Nadia Petre Lynn A. Brody Karen T. Brown Anne M. Covey George I. Getrajdman Majid Maybody Nitya Raj Constantinos T. Sofocleous Stephen B. Solomon Diane Reidy-Lagunes 《Journal of vascular and interventional radiology : JVIR》2018,29(11):1519-1526
Purpose
To identify common gene mutations in patients with neuroendocrine liver metastases (NLM) undergoing transarterial embolization (TAE) and establish relationship between these mutations and response to TAE.Materials and Methods
Patients (n = 51; mean age 61 y; 29 men, 22 women) with NLMs who underwent TAE and had available mutation analysis were identified. Mutation status and clinical variables were recorded and evaluated in relation to hepatic progression-free survival (HPFS) (Cox proportional hazards) and time to hepatic progression (TTHP) (competing risk proportional hazards). Subgroup analysis of patients with pancreatic NLM was performed using Fisher exact test to identify correlation between mutation and event (hepatic progression or death) by 6 months. Changes in mutation status over time and across specimens in a subset of patients were recorded.Results
Technical success of TAE was 100%. Common mutations identified were MEN1 (16/51; 31%) and DAXX (13/51; 25%). Median overall survival was 48.7 months. DAXX mutation status (hazard ratio = 6.21; 95% confidence interval [CI], 2.67–14.48; P < .001) and tumor grade (hazard ratio = 3.05; 95% CI, 1.80–5.17; P < .001) were associated with shorter HPFS and TTHP on univariate and multivariate analysis. Median HPFS was 3.6 months (95% CI, 1.7–5.3) for patients with DAXX mutation compared with 8.9 months (95% CI, 6.6–11.4) for patients with DAXX wild-type status. In patients with pancreatic NLMs, DAXX mutation status was associated with hepatic progression or death by 6 months (P = .024). DAXX mutation status was concordant between primary and metastatic sites.Conclusions
DAXX mutation is common in patients with pancreatic NLMs. DAXX mutation status is associated with shorter HPFS and TTHP after TAE. 相似文献9.
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