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排序方式: 共有96条查询结果,搜索用时 15 毫秒
1.
Active matrix metalloproteinases in the tear fluid of individuals with vernal keratoconjunctivitis 总被引:3,自引:0,他引:3
Kumagai N Yamamoto K Fukuda K Nakamura Y Fujitsu Y Nuno Y Nishida T 《The Journal of allergy and clinical immunology》2002,110(3):489-491
Corneal epithelial lesions distinguish vernal keratoconjunctivitis (VKC) from other ocular allergic diseases. Such lesions result from degradation of the corneal epithelial basement membrane, which comprises mostly type IV collagen and laminin. Matrix metalloproteinase 2 (MMP-2) and MMP-9 catalyze the degradation of these 2 extracellular matrix proteins. The possible role of MMP-2 and MMP-9 in the pathogenesis of corneal lesions associated with VKC was investigated by assaying tear fluid for the presence of these enzymes. Tear fluid was collected from 6 eyes of 6 patients with active VKC, 14 eyes of 14 patients with active allergic conjunctivitis, and 6 eyes of 6 nonallergic healthy volunteers. Gelatin zymography revealed that the tear fluid of healthy volunteers contained inactive proforms of both MMP-2 and MMP-9 but not the active forms of these enzymes. Active forms of MMP-2 or MMP-9 were detected in a minority of patients with allergic conjunctivitis. However, with the exception of one individual for whom active MMP-9 was not detected, tear fluid from all patients with VKC contained both proforms and active forms of MMP-2 and MMP-9. These results implicate MMP-2 and MMP-9 in the pathogenesis of corneal epithelial disorders associated with VKC. 相似文献
2.
3.
Yoshiaki Kamikawa Tomohiro Nagayama Junichi Fujisaki Daisuke Hirabayashi Kiyotsugu Kawasaki Tomofumi Hamada Youichiro Mori Yasuko Kamikawa Hiroshi Mukai Tomoaki Sato Kazumasa Sugihara 《Oral Science International》2013,10(2):87-94
ObjectivesThe present study was undertaken to evaluate the anti-fungal activity of amphotericin B (AMPH-B), flucytosine (5-FC), fluconazole (FLCZ), miconazole (MCZ), itraconazole (ITCZ), and micafungin (MCFG) against clinically isolated Candida strains from oral candidiasis (OC) patients and to collect information useful for the treatment of OC.Subjects and methodsThe study includes 116 strains of Candida isolated from patients. The Candida species were identified by polymerase chain reaction. The minimum inhibitory concentration (MIC) of each drug against each Candida species was determined.ResultsOf the 106 participants (30 males and 76 females), 57 had OC, including 42 cases of pseudomembranous OC, 11 cases of erythematous OC, 2 cases of hypertrophic OC, and 2 cases of mixed pseudomembranous/erythematous OC. The Candida species isolated were Candida albicans (93 strains), C. glabrata (19 strains), and C. tropicalis (4 strains). AMPH-B and 5-FC had low MIC values against all species of Candida and a low incidence of resistance development. In some species of Candida, FLCZ and ITCZ showed high MICs, but MCZ had a low MIC value. AMPH-B, MCZ, and ITCZ prescribed to OC patients were effective against OC with respect to alleviation of OC symptoms.ConclusionMIC values of anti-fungal drugs against Candida strains isolated from OC patients were obtained and the 3 anti-fungal drugs given to OC patients were found to be effective against OC in spite of differences in their MIC values and in the number of resistant strains (or strains with a high MIC value). 相似文献
4.
A serum amyloid A and LDL complex as a new prognostic marker in stable coronary artery disease 总被引:9,自引:0,他引:9
Ogasawara K Mashiba S Wada Y Sahara M Uchida K Aizawa T Kodama T 《Atherosclerosis》2004,174(2):349-356
BACKGROUND: Although some reports have indicated that acute phase proteins such as C-reactive protein (CRP) and serum amyloid A (SAA) can predict the prognosis in patients with acute coronary syndrome, the value of these markers in patients with stable coronary artery disease (CAD) still remains obscure. Therefore, our aim was to determine the prognostic value of inflammatory markers in patients with stable coronary artery disease. METHODS AND RESULTS: We conducted a prospective cohort study in 140 consecutive patients with stable coronary artery disease who had at least one coronary stenosis more than 50% in diameter seen on diagnostic coronary angiography (CAG). We determined serum levels of the SAA/LDL complex as a new marker in addition to CRP and SAA. Serum levels of the SAA/LDL complex were measured by a sandwich enzyme-linked immunosorbent assay (ELISA). End-points were defined as cardiac death, myocardial infarction, cerebral infarction, and coronary revascularization. End-point events occurred in 21 patients (2 death from myocardial infarction, 2 cerebral infarction, and 17 revascularization). Age (year) (OR = 1.14, CI: 1.05-1.25), diabetes mellitus (OR = 3.50, CI: 1.08-11.40), triglyceride (10mg/dl) (OR = 1.12, CI: 1.01-1.23) and SAA/LDL complex (10 microg/ml) (OR = 2.32, CI: 1.05-4.70) were independently related to the events. A reconstitution experiment suggested that the SAA/LDL complex is derived by oxidative interaction between SAA and lipoproteins. CONCLUSIONS: The SAA/LDL complex reflects intravascular inflammation directly and can be a new marker more sensitive than CRP or SAA for prediction of prognosis in patients with stable coronary artery disease. 相似文献
5.
Nobuo Murata Hideyuki Ishida Youichiro Makita Akio Odaka Kazuyuki Shimomura Kuniyasu Takahashi Daijo Hashimoto Yasuo Idezuki 《Surgery today》2003,33(4):259-263
Purpose: We examined muscle strength and walking ability after hernia repair to compare the effects of laparoscopic hernioplasty and
conventional repair.
Methods: Twenty-seven patients with primary inguinal hernias were randomly divided into two groups according to the surgical procedure:
15 patients were treated with laparoscopic hernioplasty and 12 with conventional repair. Two types of muscle testing around
the inguinal region, one by manual examination and one using a musculator, were done preoperatively and 1 week postoperatively.
Walking exercise tests were performed at the same time as muscle testing.
Results: Manual examination showed that the postoperative muscle strength of the iliopsoas muscle was decreased in six patients from
the conventional repair group, but not in any of those from the laparoscopic hernioplasty group. The musculator showed decreased
strength of the iliopsoas muscle after conventional repair, but not after laparoscopic hernioplasty. The walking exercise
test showed that conventional hernia repair influenced walking.
Conclusion: A decline in muscle strength of the iliopsoas muscle and walking ability was evident after conventional repair, but not after
laparoscopic hernioplasty. Thus, laparoscopic hernioplasty is superior to conventional repair from the perspective of muscle
testing and walking ability.
Received: March 29, 2002 / Accepted: July 2, 2002
Reprint requests to: N. Murata 相似文献
6.
Guo ZQ Otsuki T Ishi Y Inagaki A Kawakami Y Hisano Y Yamashita R Wani K Sakaguchi H Tsujita S Morimoto K Ueki A 《Environmental health and preventive medicine》2002,6(4):268-272
Objectives Several studies have reported that the secretory immunoglobulin A (S-IgA) concentration in saliva is an indicator of psychological
stress. The aim of this study was to clarify the relationship between S-IgA and the stress from academic examinations.
Methods S-IgA levels in 10 medical student volunteers from the second year course between May 4 and July 13, 2000 were examined using
the ELISA method.
Results There was a tendency for S-IgA in saliva to be higher on the day before academic examinations and during them, and lower on
the days between these examinations.
Conclusions It may be possible to use this measurement to monitor psychological stress in students and workers.
Second year medical student in the year 2000. 相似文献
7.
Taisuke Okamoto Tetsuro Mitsuse Teruyuki Kashiwagi Eiji Iwane Youichiro Sakata Kazuyuki Masuda Shinnya Ogata 《Journal of anesthesia》1996,10(1):5-9
Severe dull pain on the side of tourniquet application and marked rises in blood pressure and heart rate associated with that
pain are often observed even under adequate regional analgesia. The purpose of this study was to evaluate the effect of epidural
fentanyl on the suppression of tourniquet pain during orthopedic surgical procedures. Forty-five patients undergoing orthopedic
surgery of the lower extremities with a tourniquet were maintained by continuous epidural anesthesia with 2% lidocaine through
an epidural indwelling polyethylene catheter (L3–4). The patients were randomly allocated to the following three groups: epidural
fentanyl (100μg) (epidural group,n=15); intravenous fentanyl (100μg) (intravenous group,n=15); control (no fentanyl) (control group,n=15). The epidural or intravenous fentanyl was administered at the time of the second lidocaine injection. The severity of
tourniquet pain based on the patient's level of complaint and the total dose of supplemental analgesics requested in the epidural
group were significantly lower than those in the control group. Blood pressure during tourniquet application in the epidural
group was more stable than in the other two groups. No severe side-effects were observed in any patient. Prophylactic epidural
administration of fentanyl might be useful in the suppression of tourniquet pain. 相似文献
8.
9.
Takashi Temma Hidehiro Iida Takuya Hayashi Noboru Teramoto Youichiro Ohta Nobuyuki Kudomi Hiroshi Watabe Hideo Saji Yasuhiro Magata 《European journal of nuclear medicine and molecular imaging》2010,37(2):377-385
Purpose
Although 15O-O2 gas inhalation can provide a reliable and accurate myocardial metabolic rate for oxygen by PET, the spillover from gas volume in the lung distorts the images. Recently, we developed an injectable method in which blood takes up 15O-O2 from an artificial lung, and this made it possible to estimate oxygen metabolism without the inhalation protocol. In the present study, we evaluated the effectiveness of the injectable 15O-O2 system in porcine hearts.Methods
PET scans were performed after bolus injection and continuous infusion of injectable 15O-O2 via a shunt between the femoral artery and the vein in normal pigs. The injection method was compared to the inhalation method. The oxygen extraction fraction (OEF) in the lateral walls of the heart was calculated by a compartmental model in view of the spillover and partial volume effect.Results
A significant decrease of lung radioactivity in PET images was observed compared to the continuous inhalation of 15O-O2 gas. Furthermore, the injectable 15O-O2 system provides a measurement of OEF in lateral walls of the heart that is similar to the continuous-inhalation method (0.71?±?0.036 and 0.72?±?0.020 for the bolus-injection and continuous-infusion methods, respectively).Conclusion
These results indicate that injectable 15O-O2 has the potential to evaluate myocardial oxygen metabolism. 相似文献10.
Youichiro Kato Hirotaka Matsumoto Makio Kobayashi Yoshiie Okada Akira Kawaoi 《Pathology international》1991,41(11):811-817
To elucidate the pathogenesis of human retinoblastoma, we investigated the genomic expression in retinal tumors induced by human adenovirus type 12 in rats, using various DNA probes. Seven rats received a single intraocular inoculation of concentrated virus fluid within 24 hours after birth. Intravitreous tumors were induced in two out of seven animals (28.5%) within 30 to 64 days after the inoculation. A remarkably uniform histologic feature, i.e., neuroblastic cells in association with Homer-Wright pseudorosettes, was present in all cases. The adenovirusrelated oncoprotein gene E1A and human retinoblastoma susceptibility gene were detected in the tumors by Southern blot hybridization. In situ hybridization analysis demonstrated expression of adenovirus type 12 E1A gene in the inner granular layer of the retina. It was suggested that integration of adenovirus type 12 E1A fragment with the host genome and expression of the gene were required for induction of this tumor. 相似文献