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1.
Yusuke Satoh Hitoshi Kotani Yuichi Iida Takahito Taniura Yoshitomo Notsu Mamoru Harada 《Cancer science》2020,111(7):2248-2258
Myeloid‐derived suppressor cells (MDSCs) play a crucial role in immunosuppression in tumor‐bearing hosts. MDSCs express arginase‐I and indoleamine 2,3‐dioxygenase; they suppress T‐cell function by reducing the levels of l ‐arginine and l ‐tryptophan, respectively. We examined the anticancer effects of supplementation of these amino acids in CT26 colon carcinoma‐bearing mice. Oral supplementation of l ‐arginine or l ‐tryptophan (30 mg/mouse) did not affect tumor growth, whereas oral supplementation of d ‐arginine was lethal. Supplementation of l ‐arginine showed a tendency to augment the efficacy of cyclophosphamide (CP). CP reduced the proportions of granulocytic MDSCs and increased the proportions of monocytic MDSCs in the spleen and tumor tissues of CT26‐bearing mice. l ‐Arginine supplementation alone did not affect the MDSC subsets. CP treatment tended to reduce the plasma levels of l ‐arginine in CT26‐bearing mice and significantly increased the number of tumor‐infiltrating CD8+ T cells. In addition, l ‐arginine supplementation significantly increased the proportions of tumor peptide‐specific CD8+ T cells in draining lymph nodes. Importantly, additional supplementation of l ‐arginine significantly increased the number of cured mice that were treated with CP and anti‐PD‐1 antibody. Totally, l ‐arginine supplementation shows promise for boosting the therapeutic efficacy of chemoimmunotherapy. 相似文献
2.
Basic fibroblast growth factor‐treated adipose tissue‐derived mesenchymal stem cell infusion to ameliorate liver cirrhosis via paracrine hepatocyte growth factor 下载免费PDF全文
3.
Takako Fujita Yukiko Ihara Hitomi Hayashi Atsushi Ishii Hiroshi Ideguchi Takahito Inoue Taichi Imaizumi Toshiyuki Yamamoto Shinichi Hirose 《Congenital anomalies》2020,60(6):189-193
Coffin-Siris syndrome (CSS) is a congenital anomaly syndrome characterized by developmental delay, coarse facial features, and hypoplasia of the fifth digit's nail or phalanges. Herein, we report a case of the 8-year-old female patient who showed developmental delay associated with dysplasia in the macular and large toe area. Comprehensive genomic analysis showed no possible candidate variants, but the subsequent genomic copy number analysis revealed a novel exonic deletion in the coding region of AT-rich interactive domain-containing protein 1B (ARID1B), a gene responsible for CSS. Genomic copy number analysis can aid in diagnosing CSS by confirming undiagnosed exonic deletions in ARID1B. Furthermore, this is the first report of CSS associated with bilateral macular dysplasia. 相似文献
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Ultrasonographic evaluation of gastrointestinal graft‐versus‐host disease after hematopoietic stem cell transplantation 下载免费PDF全文
Mutsumi Nishida Akio Shigematsu Megumi Sato Yusuke Kudo Satomi Omotehara Tatsunori Horie Takahito Iwai Tomoyuki Endo Akihiro Iguchi Hitoshi Shibuya Kanako Hatanaka Chikara Shimizu Takanori Teshima 《Clinical transplantation》2015,29(8):697-704
Gastrointestinal graft‐versus‐host disease (GI‐GVHD) is a major and life‐threatening complication of hematopoietic stem cell transplantation (HSCT). This study evaluated the efficacy of ultrasonography (US) for assessing and monitoring GI‐GVHD. GI tract was evaluated by US in 81 patients. US findings were positive in 43 patients, including 11 false positive, and negative in 38 patients. Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of US for the diagnosis of GI‐GVHD were 100%, 78%, 74%, 100%, and 86%, respectively. Diffuse wall thickening of the ileum was the most frequent finding in patients with GI‐GVHD. Severity of GI‐GVHD was correlated with the thickness of internal low echoic layer of the wall, the echogenicity of mesenteric fat tissue, and the intensity of Doppler signaling. We classified US findings of GI‐GVHD into four US grades. There was a significant correlation between clinical stage of GI‐GVHD and the US grade. These ultrasonographic abnormalities were improved with clinical improvement of GI‐GVHD upon treatment. Thus, US is an effective and efficient non‐invasive means of identifying the extent and severity of GI‐GVHD and monitoring response to treatment. 相似文献
9.
Shinkai Inoue Atsushi Ishii Goro Shirotani Makoto Tsutsumi Eiji Ohta Masatoshi Nakamura Toshiko Mori Takahito Inoue Gen Nishimura Atsushi Ogawa Shinichi Hirose 《Pediatrics international》2014,56(4):e26-e29
We report a boy with Desbuquois dysplasia type 1. He had the typical skeletal changes: a “Swedish key” appearance of the proximal femora; advanced carpal ossification and other distinctive features of the hand, including an extra‐ossification center at the base of the proximal phalanx of the index and middle fingers; dislocation of the metacarpophalangeal joint of the index finger; and bifid distal phalanx of the thumb. In addition, he presented with very severe prenatal growth failure, respiratory distress as a neonate, subsequent failure to thrive and susceptibility to airway infection, and sudden death in early childhood. Molecular analysis identified homozygous 1 bp deletion in the Calcium‐Activated Nucleotidase 1 gene (CANT1). To our knowledge, this is the first report of Desbuquois dysplasia type 1 in Japan. Our experience suggests potential lethality in the disorder. 相似文献
10.
The purpose of this study was to investigate the deformation and flexural properties of acrylic and urethane polymers reinforced with glass fiber sheet. Four types of specimen--self-curing resin plate (R), light-curing oligomer plate containing a reinforcement (GO), and self-curing resin plate containing a reinforcement on one (GR) or both (GRG) sides--were prepared with three thicknesses: 1.5, 2.4, and 3.0 mm. Gaps between polymerized test specimen and a standard metal plate were measured at the corner (C), middle of the long sides (LS), and middle of the short sides (SS). The gaps for R were 0-2.0 microm. GO and GR markedly deformed at Points C, LS, and SS, and the degree of deformation increased as GO became thinner. Flexural strength was significantly increased by the reinforcement (p < 0.05). The flexural moduli of 3.0-mm thick R, GO, and GR were significantly smaller than that of 1.5-mm thick specimens. 相似文献