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排序方式: 共有1392条查询结果,搜索用时 15 毫秒
1.
Federico Bove A. Della Valle M. Miranda D. Capitani 《LO SCALPELLO-OTODI Educational》2014,28(3):165-168
Complex humeral fractures represent an exciting challenge in traumatology. Recently, the use of MIPO techniques has been gaining success in traumatology as well. Concerning our experience, we do not recommend the use of these techniques in all fracture types and kinds of patients. 相似文献
2.
Perioperative pain management after fibular free flap harvesting for head‐and‐neck reconstruction using mini‐catheters to inject local anesthetic: A pilot study 下载免费PDF全文
3.
Angela Silvano Giulio Menegazzi Silvia Peppicelli Caterina Mancini Alessio Biagioni Alessandro Tubita Ignazia Tusa Jessica Ruzzolini Matteo Lulli Elisabetta Rovida Persio Dello Sbarba 《Oncology research》2021,29(1):33-46
This study was directed to deepen the effects of nutrient shortage on BCR/Ablprotein expression and signaling in
chronic myeloid leukemia (CML) cells. The backbone of the study was cell culture in medium lacking glucose,
the consumption of which we had previously shown to drive BCR/Ablprotein suppression, and glutamine, the
other main nutrient besides glucose. In this context, we focused on the role of lactate, the main by-product of
glucose metabolism under conditions of rapid cell growth, in particular as a modulator of the maintenance of
CML stem/progenitor cell potential, a crucial determinant of disease course and relapse of disease. The results
obtained indicated that lactate is a powerful surrogate of glucose to prevent the suppression of BCR/Abl signaling and is therefore capable to maintain BCR/Abl-dependent CML stem/progenitor cell potential. A number of
metabolism-related functional and phenotypical features of CML cells were also determined. Among these, we
focused on the effect of lactate on oxygen consumption rate, the dependence of this effect on the cell surface
lactate carrier MCT-1, and the relationship of the lactate effect to pyruvate and to the activity of mitochondrial
pyruvate carrier. 相似文献
4.
Noviello S Ianniello F Leone S Esposito S 《The Journal of antimicrobial chemotherapy》2003,52(5):869-872
OBJECTIVES: Garenoxacin is a novel des-F(6)quinolone that has shown excellent antimicrobial activity against a wide range of clinically important microorganisms. In this study, its activity was examined, in comparison with that of other antimicrobial agents, by susceptibility and time-kill testing against Staphylococcus aureus, Streptococcus pyogenes and respiratory pathogens. METHODS: Overall, 200 bacterial strains were tested. The antimicrobial activity of garenoxacin was compared with that of ciprofloxacin, levofloxacin, moxifloxacin, amoxicillin, co-amoxiclav, cefuroxime, cefotaxime, ceftriaxone, imipenem, erythromycin and clarithromycin. In addition, the bactericidal activity of garenoxacin, moxifloxacin, levofloxacin and ciprofloxacin was evaluated by time-kill analysis against four strains each of staphylococci [two methicillin-susceptible (MSSA) and two methicillin-resistant (MRSA)], pneumococci (two penicillin-susceptible and two penicillin-resistant) and Streptococcus pyogenes (two erythromycin-susceptible and two erythromycin-resistant). Antibiotics were tested at concentrations 1-8 x MIC. RESULTS: MIC90 values of garenoxacin for the MSSA and MRSA strains were 0.03 and 2 mg/L, respectively. Among all the quinolones tested, garenoxacin yielded the lowest MIC values against all pneumococci (MIC90 0.12 mg/L) irrespective of macrolide resistance; the rank order of activity was garenoxacin> moxifloxacin>levofloxacin>ciprofloxacin. Excellent activity was shown also against Haemophilus influenzae (MIC90 or= 3 log10 decrease in viable counts (cfu/mL) within 3 h at 4 x MIC, whereas a moderate, slower killing rate was observed versus streptococci. CONCLUSIONS: This investigational des-F(6)quinolone represents a promising alternative for the treatment of respiratory tract infections. 相似文献
5.
Pryce TM Kay ID Palladino S Heath CH 《Diagnostic microbiology and infectious disease》2003,47(3):487-496
We report the development and evaluation of a real-time PCR assay using the LightCycler instrument for the detection of C. albicans and A. fumigatus DNA in whole blood. Recently published consensus criteria for the diagnosis of invasive fungal infection (IFI) were used for all patient samples. Unique and published primer pairs were developed and assessed for sensitivity, specificity, and reproducibility to detect C. albicans and A. fumigatus DNA in samples spiked with purified DNA, and whole blood samples from 8 high-risk patients and 45 negative controls. The real-time assay demonstrated an analytical sensitivity of 10 fg of purified C. albicans and A. fumigatus DNA and was found to be specific for each species. The standardized approach was highly reproducible and detected C. albicans and A. fumigatus DNA in two patients with proven IFI and in one patient with a possible IFI. In addition, we report for the first time the use of recently published international consensus criteria for the diagnosis of IFI in the evaluation of a mildly invasive fungal diagnostic assay. Standardized clinical criteria and a more standardized approach to detect fungal DNA in less invasive patient samples, may permit a more reliable comparison of future studies. A rapid real-time detection of fungal DNA in whole blood, combined with standard clinical markers of response, may be more useful for monitoring patients at risk of developing IFI than other diagnostic methods currently available. 相似文献
6.
Saviola Gianantonio Abdi-Ali Lul Povino Maria Rosaria Campostrini Lorella Sacco Silvano Dalle Carbonare Luca 《Clinical rheumatology》2018,37(7):2019-2019
Clinical Rheumatology - One of the author names on this article was incorrectly tagged during the article mark-up; Luca Dalle Carbonare’s name has now been correctly tagged, with first name... 相似文献
7.
Silvano Arieti 《Contemporary psychoanalysis》2013,49(1):51-68
This discussion praises Object Relations in Psychoanalytic Theory by Jay Greenberg and Stephen Mitchell for the clarity with which it compares various psychoanalytic theories and their pedagogical usefulness. However, it emphasizes that the book views comparative psychoanalysis based on choices and assumptions with which many might differ. “Object relations” is only one of several possible lenses through which psychoanalytic theories might have been compared. By selecting object relations as the organizing perspective the authors ignore some important theorists such as Arlow and Brenner or Erik Erikson. It also notes that Greenberg and Mitchell view the choice of theoretical position as simply a matter of personal preference. This ignores the possibility of scientifically evaluating which psychoanalytic approach is most likely to achieve the best results. 相似文献
8.
9.
Chiara Barisione Silvano Garibaldi Claudio Brunelli Manrico Balbi Paolo Spallarossa Marco Canepa Pietro Ameri Francesca Viazzi Daniela Verzola Alessandra Lorenzoni Riccardo Baldassini Domenico Palombo Bianca Pane Giovanni Spinella Giorgio Ghigliotti 《Internal and emergency medicine》2016,11(2):205-212
Chronic kidney disease (CKD), cardiac damage (CD) and the combination of the two are associated with increased morbidity and death in patients admitted to vascular surgery units. We assessed the prevalence of cardiac and renal damage and cardiorenal syndrome (CRS) in 563 patients with abdominal aortic aneurysms (AAA) who underwent cardiac screening before either an endovascular procedure (EVAR) or open surgery (OS) for aneurysm repair. CD was defined by ≥stage B as per the ACC/AHA classification of congestive heart failure (CHF), while CKD was defined by estimated GFR <60 mL/min/1.73 m2 (CKD-EPI). Anemia [World Health Organization (WHO) guidelines] and iron deficiency (ID) (criteria for CHF patients) were also calculated. AAA patients were stratified into the following groups: CD, CKD, CRS or none of these conditions [no risk factors (NoRF)]. The prevalence of isolated cardiac and renal structural damage, of combined cardiorenal damage and of ID was 24.1, 15.0, 20.6 and 23.4 %, respectively. The frequency of anemia (mostly unrecognized) among the groups increased from NoRF (12.8 %)/CKD (19 %)/CD (25 %) up to CRS (38.8 %). This large-scale observational study provides clues for the increased CD/CKD risk profiles of unselected AAA patients, and underlines the need for better identification of ID/anemia and for appropriate treatment of CKD and CD before these patients undergo EVAR/OS. 相似文献
10.
Prevalence and Factors Associated with Subclinical Left Ventricular Systolic Dysfunction Evaluated by Mid‐Wall Mechanics in Rheumatoid Arthritis 下载免费PDF全文