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Tetsuji Terazawa Takeshi Kato Masahiro Goto Katsuya Ohta Shingo Noura Hironaga Satake Yoshinori Kagawa Hisato Kawakami Hiroko Hasegawa Kazuhiro Yanagihara Tatsushi Shingai Ken Nakata Masahito Kotaka Masayuki Hiraki Ken Konishi Shiro Nakae Daisuke Sakai Yukinori Kurokawa Toshio Shimokawa Taroh Satoh 《The oncologist》2021,26(1):17-e47
Lessons Learned
- Panitumumab monotherapy showed favorable efficacy and feasibility in the treatment of frail or elderly patients with RAS wild‐type unresectable colorectal cancer.
- It is especially effective for left‐sided tumors; therefore, panitumumab as first‐line treatment could be an additional therapeutic option for frail elderly patients, particularly in those who are unsuitable for upfront oxaliplatin‐based or irinotecan‐based combination regimens.
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Atsushi Tanikawa Satoshi Seki Takuya Yasuda Eiju Hasegawa 《The American journal of emergency medicine》2019,37(9):1809.e1-1809.e3
Half-life of the antipsychotic vegetamin is very long, partially due to the presence of phenobarbital, and mortality due to phenobarbital poisoning is high. Here, we present the case of a 22-year-old female admitted to the emergency department with disturbed consciousness due to vegetamin overdose. Her blood phenobarbital level was elevated to 123 μg/ml. Phenobarbital undergoes enterohepatic circulation, and its retention in the intestine causes its blood levels to remain sustained. The utility of hemodialysis for drug poisoning has been previously reported; however, its efficiency is not yet established and its efficacy is low for drugs with long half-lives such as phenobarbital. Therefore, we performed a two-tube approach to adsorb phenobarbital in the intestines with activated charcoal delivered via a gastric tube and to remove the phenobarbital-adsorbed activated charcoal using whole bowel irrigation via an ileus tube 2 h later. The patient successfully eliminated the charcoal via stool, the blood phenobarbital level decreased drastically without hemodialysis, and the clinical course improved. We propose that this two-tube approach is suitable for treatment of poisoning with drugs that undergo enterohepatic circulation and have long half-lives. 相似文献
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Yoella Bereby‐Meyer Sayuri Hayakawa Shaul Shalvi Joanna D. Corey Albert Costa Boaz Keysar 《Topics in Cognitive Science》2020,12(2):632-643
Theories of dishonest behavior implicitly assume language independence. Here, we investigated this assumption by comparing lying by people using a foreign language versus their native tongue. Participants rolled a die and were paid according to the outcome they reported. Because the outcome was private, they could lie to inflate their profit without risk of repercussions. Participants performed the task either in their native language or in a foreign language. With native speakers of Hebrew, Korean, Spanish, and English, we discovered that, on average, people inflate their earnings less when they use a foreign language. The outcome is explained by a dual system account that suggests that self‐serving dishonesty is an automatic tendency, which is supported by a fast and intuitive system. Because using a foreign language is less intuitive and automatic, it might engage more deliberation and reduce the temptation to lie. These findings challenge theories of ethical behavior to account for the role of the language in shaping ethical behavior. 相似文献
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