全文获取类型
收费全文 | 932篇 |
免费 | 52篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 13篇 |
妇产科学 | 30篇 |
基础医学 | 99篇 |
口腔科学 | 12篇 |
临床医学 | 79篇 |
内科学 | 188篇 |
皮肤病学 | 22篇 |
神经病学 | 116篇 |
特种医学 | 36篇 |
外科学 | 77篇 |
综合类 | 31篇 |
预防医学 | 60篇 |
眼科学 | 29篇 |
药学 | 124篇 |
中国医学 | 35篇 |
肿瘤学 | 39篇 |
出版年
2023年 | 7篇 |
2022年 | 9篇 |
2021年 | 23篇 |
2020年 | 17篇 |
2019年 | 10篇 |
2018年 | 15篇 |
2017年 | 9篇 |
2016年 | 18篇 |
2015年 | 18篇 |
2014年 | 24篇 |
2013年 | 42篇 |
2012年 | 47篇 |
2011年 | 57篇 |
2010年 | 30篇 |
2009年 | 27篇 |
2008年 | 68篇 |
2007年 | 54篇 |
2006年 | 57篇 |
2005年 | 37篇 |
2004年 | 32篇 |
2003年 | 42篇 |
2002年 | 29篇 |
2001年 | 43篇 |
2000年 | 30篇 |
1999年 | 26篇 |
1998年 | 15篇 |
1997年 | 10篇 |
1996年 | 7篇 |
1995年 | 11篇 |
1994年 | 5篇 |
1992年 | 20篇 |
1991年 | 12篇 |
1990年 | 13篇 |
1989年 | 10篇 |
1988年 | 11篇 |
1987年 | 12篇 |
1986年 | 11篇 |
1985年 | 7篇 |
1984年 | 5篇 |
1983年 | 3篇 |
1980年 | 3篇 |
1978年 | 6篇 |
1970年 | 6篇 |
1968年 | 3篇 |
1966年 | 6篇 |
1963年 | 3篇 |
1959年 | 3篇 |
1958年 | 6篇 |
1957年 | 8篇 |
1954年 | 5篇 |
排序方式: 共有995条查询结果,搜索用时 423 毫秒
1.
2.
Petry Vanessa Bonadio Renata Colombo Cagnacci Allyne Queiroz Carneiro Senna Luiz Antonio Leite Campos Roberta do Nascimento Galvão Cotti Guilherme Cutait Hoff Paulo M. Fragoso Maria Candida Barisson Villares Estevez-Diz Maria del Pilar 《Familial cancer》2020,19(1):47-53
Familial Cancer - The risk of radiotherapy-induced malignancies (RIMs) is a concern when treating Li–Fraumeni syndrome (LFS) or Li–Fraumeni Like (LFL) patients. However, the type of... 相似文献
3.
JA HYEON KU CHEOL KWAK SEUNG-JUNE OH EUNSIK LEE SANG EUN LEE JAE-SEUNG PAICK 《International journal of urology》2004,11(7):489-493
BACKGROUND: Our aims in the present study were to estimate the influences of pain and urinary symptoms on quality of life, and to determine which of these two variables has the most predictive power with respect to quality of life in young men with chronic prostatitis-like symptoms. METHODS: Chronic prostatitis-like symptoms were measured by the National Institutes of Health-Chronic Prostatitis Symptom Index. Of the 28,841 men aged 20 years who lived in the study community, 18,495 men (a response rate 64.1%) agreed to participate in the study. A total of 1057 men who complained of symptoms indicative of chronic prostatitis were included in the study. The influences of pain and urinary symptoms on quality of life were determined using logistic regression analysis. The receiver operating characteristic (ROC) curve was used to estimate the predictive ability of each of these variables with respect to quality of life. RESULTS: Results from multivariate analysis showed that both pain and urinary symptoms were associated with an increased likelihood of impaired quality of life, although pain contributed more to a reduced quality of life than urinary symptoms. Relative to men who experienced mild pain, men who experienced moderate pain had a 3.9-fold risk of poor quality of life (odds ratio [OR], 3.87; 95% confidence interval [CI], 2.86-5.23; P < 0.001) and those who experienced severe pain had a 15.7-fold risk of reduced quality of life (OR, 15.68; 95% CI, 6.59-37.35; P < 0.001). Moderate urinary symptoms were associated with a 1.4-fold risk of bother (OR, 1.41; 95% CI, 1.01-1.99; P < 0.001) and severe urinary symptoms were associated with 2.4-fold risk (OR, 2.39; 95% CI, 1.37-4.12; P < 0.001), relative to mild urinary symptoms. Comparison of the effects of pain and urinary symptoms showed that pain severity had the most predictive power for bother, quality of life, and quality-of-life impact. The areas under the ROC curves for bother, quality of life, and quality-of-life impact were 71.3%, 69.3% and 72.5%, respectively. CONCLUSION: Urinary symptoms and pain might be associated with an increased likelihood of impaired quality of life in young men with chronic prostatitis-like symptoms. In addition, our findings suggest that pain severity is the most influential variable for determining quality of life in this population. 相似文献
4.
Pincivero DM Aldworth C Dickerson T Petry C Shultz T 《European journal of applied physiology》2000,81(6):504-509
It has been hypothesized that the ability of the neuromuscular system to co-contract muscles for joint stabilization may
be impaired during the development of fatigue. The purpose of this study was to examine muscle activation of the quadriceps
and hamstring muscles during a prolonged closed kinetic chain exercise, the forward lunge. Eight males and two females [mean
(SD) age 26.0 (2.3) years, height 177.2 (13.6) cm, body mass 82.8 (17.1) kg] with no prior knee pathology volunteered for
this study. Subjects performed repeated forward lunges onto their dominant leg at the cadence of one full lunge cycle every
2 s, until the point of volitional failure. Digital switches were positioned to record foot-strike and knee-strike of the
lunge leg at the midpoint of the lunge, as well as heel-strike upon return to stance. During the lunge performance, surface
electromyographic (EMG) signals of the vastus lateralis (VL), vastus medialis (VM), biceps femoris (BF), and semitendinosus
(ST) muscles of the supporting leg were measured. Heart rate was also monitored every 30 s during the performance. All EMG
data were full-wave rectified, partitioned into up and down phases, and integrated over the entire exercise period. The results
demonstrated a significant increase in activation of the VL, VM, and BF during performance of the forward lunge to volitional
failure (P < 0.05). No significant increase was shown for the ST. Heart rate increased significantly over the course of the lunge. These
findings suggest that activation of the VL, VM, and BF muscles occurs as a unit during performance of the forward lunge during
both concentric and eccentric lunge phases.
Accepted: 25 October 1999 相似文献
5.
Delayed Enhancement of Acetaminophen Hepatotoxicity by GeneralAnesthesia Using Diethyl Ether or Halothane. WELLS, P. G., RAMJI,P., AND KU, M. S. W. (1986). Fundam. App. Toxicol 6, 299306.Acetaminophen (Tylenol) is a widely used analgesic/antipyreticdrug which is enzymatically bioactivated, or toxified, by thecytochromes P-450 to a hepatotoxic reactive intermediary metabolite.Brief general anesthesia with diethyl ether has been shown toinhibit both the toxifying cytochromes P-450 and enzymatic glucuronidation,the latter constituting up to 60% of acetaminophen eliminationvia a nontoxifying pathway. Thus ether potentially could producea temporally differentiated inhibition of bioactivating and"detoxifying" pathways, resulting in an enhancement of acetaminophenhepatotoxicity if the balance favored bioactivation. To evaluatethis possibility, separate groups of male NIH strain mice weretreated with acetaminophen at different times after 5 min ofanesthesia with ether. Ether produced a 40-fold enhancementin acetaminophen hepatotoxicity as determined by plasma glutamic-pyruvictransaminase (GPT) concentrations. This toxicologic enhancementwas observed only if acetaminophen administration was delayed,with a maximal enhancement when acetaminophen was given 6 hrafter ether, and no effect with a delay of 16 hr. Similar studiesin male CD-1 mice were carried out using halothane (Fluothane)as the general anesthetic given either over 5 min or over 1hr. While halothane given over 5 min had no effect, a 1 hr anestheticduration produced a 10-fold increase in acetaminophen hepatotoxicityas determined by peak GPT concentration, with no observed hepatotoxicityin the halothane controls. Toxicologic enhancement occurredonly with delayed administration of acetaminophen; however,the maximal enhancement observed with a 6-hr delay was stillevident with a 12-hr delay. Conversely, inhibition of acetaminophenhepatotoxicity was observed if acetaminophen was given either2 hr or 18 hr after halothane. These observations may have clinicalrelevance, and they indicate potential complications in theinterpretation of results obtained from animals subjected togeneral anesthesia. 相似文献
6.
【目的】 分析母语非英语国家科技期刊出版策略,为国内期刊国际化发展提供借鉴。【方法】 以巴西SciELO平台为例,通过文献调研、平台调研、双语期刊案例调研等方法剖析巴西期刊出版策略。【结果】 作为国际上首个开放出版平台,SciELO平台更多是面向本国期刊质量提升与评估优化、数字化出版、出版语种平衡及国际影响力提升需要而提出的发展策略。【结论】 SciELO平台本身就是一种国际化策略,发挥了“造船出海“的功能,对整体提升巴西期刊国际影响力具有非常重要的作用,其数字出版平台的牵引作用和语种的平衡发展方式值得我国借鉴。 相似文献
7.
With the growing use of computers and on-line hospital information systems, a need exists for health care managers trained in computing and computer applications. This article reviews the advances in health care computing and reports on the design and implementation of a new course in a specific computer application, known as expert systems, in a health administration curriculum. The specific course framework is described and several student projects are presented and discussed. 相似文献
8.
库宝善 《北京大学学报(医学版)》1999,31(3):D2
睡眠有3种成分:浅睡眠、慢波睡眠(slowwavesleep,SWS)和快眼动睡眠。提出催眠药物开发新构想,即SWS是最重要的睡眠成分,选择性增加深睡眠的催眠药物最重要,它将对改善失眠,辅助治疗焦虑症、抑郁症和痴呆症具有重要意义。近十年研究进展包括:(1)腹外侧视前区结节乳头体可能是睡眠觉醒的中枢发生部位。基底前脑吻端pGD2敏感性睡眠促进区参与睡眠调节;(2)生长激素释放激素、褪黑激素、pGD2、IL1和腺苷均可增加SWS。本系神经药理研究室关于SWS的研究工作包括:(1)建立起家兔和大鼠睡眠成分自动分析系统(autoanalysissleepingstagessystems,ASS);(2)利用ASS研究了免疫增强剂如转移因子、胞壁酰二肽、肿瘤坏死因子,以及5HT1A受体激动剂和5HT2受体拮抗剂对睡眠成分的影响;(3)探讨5HT1A受体、REM睡眠和5HT2受体间的关系。近十年睡眠调节的研究进展证明“构想”的可行性和正确性,并提示,在中枢可能存在免疫增强TNF增多5HT更新率增加SWS途径。激动5HT1A自身受体与拮抗5HT2受体有类似效果,二者间有协同作用。开发选择性延长 相似文献
9.
目的以反相高效液相色谱法(RP-HPLC)测定甘露药浴颗粒(外用)中盐酸麻黄碱的含量。方法色谱柱:WatersC18(150mm×4.6mm);流动相:水-乙烷-十二烷基硫酸钠-磷酸(650∶350∶5∶1);流速:1.0mL/min;柱温:26℃;检测波长:210nm。结果该方法的线性范围为0.127~0.130μg/μL(r=0.9996,n=5),平均回收率为99.72%,RSD=1.12%。结论本法简便、准确、重现性好,可用于该制剂的质量控制。 相似文献
10.
Leonard L. Bailey John G. Jacobson William H. Merritt Robin W. Doroshow Eugene L. Petry 《The American journal of cardiology》1982,49(4):766-770
Since April 1976, nine infants less than 1 month of age underwent a Mustard intraatrial baffle procedure. All had transposition of the great arteries and were persistently symptomatic or hypoxic after the Rashkind balloon atrioseptostomy. Two had an associated large ventricular septal defect patched at the time of physiologic correction. The average age of the infants was 11.6 days (range 36 hours to 28 days). Weight averaged 3.4 kg (range 2.5 to 4.2). In all the Mustard procedure was performed using deep hypothermie circulatory arrest, averaging 71 minutes (range 48 to 88) at a mean core temperature of 13 °C. An average of 2.8 days of postoperative ventilatory assistance was required. One death occurred in a 28 day old male infant with an associated ventricular septal defect who, the morning after operation, had a sudden unresponsive cardiac standstill. The postoperative hospitalization period averaged 15 days (range 10 to 23). Follow-up evaluation has extended from 4 to 63 months (average 31). Six patients were restudied 2 to 21 months postoperatively. One had obstruction of the superior limb of the baffle, which had separated from the right atrial wall permitting a modest right to left shunt. She has had uneventful repair employing a unique modification of Senning's operation. Another child has asymptomatic partial obstruction of the superior limb of the baffle demonstrated angiographically. None has pulmonary venous obstruction and all have prevailing normal sinus rhythm. Significant right ventricular dysfunction has been demonstrated in one. Early correction in these persistently symptomatic or hypoxic neonates with transposition of the great arteries with or without a ventricular septal defect has obviated the need for palliative operations and produced gratifying early and late results. 相似文献