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排序方式: 共有5021条查询结果,搜索用时 31 毫秒
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A case of bullous pemphigoid associated with psoriasis vulgaris showing Hailey–Hailey disease‐like histopathological changes in regenerated epidermis without genomic mutation in ATP2C1 or ATP2A2 gene 下载免费PDF全文
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Chikako Kusunoki Takuya Hamakawa Kazuhiro Nishikawa Hiromichi Sato Sayumi Imamura Satoru Miyahara Yu Sakano Hazuki Miyazaki Hiroto Seto Ryuta Ueda Reishi Toshiyama Masaaki Miyo Yusuke Takahashi Kenji Sakai Masakazu Miyake Atsushi Miyamoto Takeshi Kato Kiyoshi Mori Motohiro Hirao 《Asian journal of endoscopic surgery》2021,14(4):794-797
Laparoscopic wedge resection (LWR) for intraluminal gastrointestinal stromal tumor (GIST) leads to excessive resection of normal gastric wall. We report a case of GIST around the cardia successfully treated with full-thickness partial resection using a hybrid approach of laparoscopic surgery and single-incision intragastric surgery (SIIGS). A 69-year-old woman had a 5 cm intraluminal GIST at the posterior wall around the cardia. Submucosal injection of glycerin and indigo carmine was performed with transoral endoscopy. Circumferential seromuscular incision followed by placement of seromuscular sutures to invert the lesion into the stomach was performed under laparoscopy. By SIIGS, resection of the inverted mucosa and retrieval of the tumor were completed. A hybrid approach consisting of laparoscopic wall-inversion surgery and SIIGS was useful for intraluminal GIST and may expand the indications for laparoscopic wall-inversion surgery by removing size limitations. 相似文献
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Takashi Kamio Akiko Imaizumi Keiichi Nishikawa Takeo Shibui Kenji Inoue Kenichi Matsuzaka Junichiro Sakamoto Tsukasa Sano 《Oral Radiology》2014,30(3):236-242
We report our experience of a case with a malignant tumor of the mandible in which diagnostic imaging played an important role in the differential diagnosis and therapeutic strategy decisions. The patient was a 78-year-old woman who visited our hospital because of poor healing after tooth extraction. Multiple cytological diagnoses provided class II results, and a histopathological diagnosis of a biopsy also failed to show malignant findings. Therefore, a definitive diagnosis could not be made. Although the patient had a history of osteoporosis treatment, details of her medications were unclear. Therefore, bisphosphonate-related osteonecrosis of the jaw (BRONJ) could not be excluded, causing difficulty in management of the patient’s condition. Eventually, we mainly focused on the diagnostic imaging and planned the therapeutic strategy in accordance with treatment for a malignant tumor. A postoperative histopathological examination of the surgical specimen revealed squamous cell carcinoma. It is sometimes difficult to differentiate among atypical diseases such as malignant tumors of the mandible and BRONJ, based solely on clinical or diagnostic imaging results. However, in the present patient, diagnostic imaging suggested a malignant tumor, and the appropriate treatment could be selected. 相似文献
5.
The utility of intra‐operative three‐dimensional transoesophageal echocardiography for dynamic measurement of stroke volume 下载免费PDF全文
K. Suehiro K. Tanaka T. Yamada T. Matsuura T. Funao T. Mori K. Nishikawa 《Anaesthesia》2015,70(2):150-159
Measurement of left ventricular stroke volume and cardiac output is very important for managing haemodynamically unstable or critically ill patients. The aims of this study were to compare stroke volume measured by three‐dimensional transoesophageal echocardiography with stroke volume measured using a pulmonary artery catheter, and to examine the ability of three‐dimensional transoesophageal echocardiography to track stroke volume changes induced by haemodynamic interventions. This study included 40 cardiac surgery patients. Haemodynamic variables were measured before and 2 min after haemodynamic interventions, which consisted of phenylephrine 100 μg or ephedrine 5 mg. We used Bland–Altman analysis to assess the agreement between the stroke volume measured by three‐dimensional transoesophageal echocardiography and by the pulmonary artery catheter. Polar‐plot and 4‐quadrant plot analyses were used to assess the trending ability of three‐dimensional transoesophageal echocardiography compared with the pulmonary artery catheter. Bias and percentage error were ?1.2 ml and 20%, respectively. The concordance rate in the 4‐quadrant analysis after phenylephrine and ephedrine administration was 75% and 84%, respectively. In the polar‐plot analysis, the angular concordance rate was 66% and 73% after phenylephrine and ephedrine administration, respectively. Three‐dimensional transoesophageal echocardiography was clinically acceptable for measuring stroke volume; however, it was not sufficiently reliable for tracking stroke volume changes after haemodynamic interventions. 相似文献
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MicroRNA‐205 inhibits cancer cell migration and invasion via modulation of centromere protein F regulating pathways in prostate cancer 下载免费PDF全文
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Nobuyuki Nishikawa Rie Yago Yuichiro Yamazaki Hiromitsu Negoro Mari Suzuki Masaaki Imamura Yoshinobu Toda Kazunari Tanabe Osamu Ogawa Akihiro Kanematsu 《BMC urology》2015,15(1)
Background
To investigate the expression of parathyroid hormone (PTH)/PTH-related peptide (PTHrP) receptor 1 (PTH1R) in clinical specimens of normal and diseased bladders. PTHrP is a unique stretch-induced endogenous detrusor relaxant that functions via PTH1R. We hypothesized that suppression of this axis could be involved in the pathogenesis of bladder disease.Methods
PTH1R expression in clinical samples was examined by immunohistochemistry. Normal kidney tissue from a patient with renal cancer and bladder specimens from patients undergoing ureteral reimplantation for vesicoureteral reflux or partial cystectomy for urachal cyst were examined as normal control organs. These were compared with 13 diseased bladder specimens from patients undergoing bladder augmentation. The augmentation patients ranged from 8 to 31 years old (median 15 years), including 9 males and 4 females. Seven patients had spinal disorders, 3 had posterior urethral valves and 3 non-neurogenic neurogenic bladders (Hinman syndrome).Results
Renal tubules, detrusor muscle and blood vessels in normal control bladders stained positive for PTH1R. According to preoperative urodynamic studies of augmentation patients, the median percent bladder capacity compared with the age-standard was 43.6% (range 1.5–86.6%), median intravesical pressure at maximal capacity was 30 cmH2O (range 10–107 cmH2O), and median compliance was 3.93 ml/cmH2O (range 0.05–30.3 ml/cmH2O). Detrusor overactivity was observed in five cases (38.5%). All augmented bladders showed negative stainings in PTH1R expression in the detrusor tissue, but positive staining of blood vessels in majority of the cases.Conclusions
Downregulation of PTH1R may be involved in the pathogenesis of human end-stage bladder disease requiring augmentation. 相似文献10.
S Wakisaka H Ichikawa S Nishikawa S Matsuo Y Takano M Akai 《Archives of oral biology》1987,32(6):449-453
The correlation between substance P (SP) and vasoactive intestinal polypeptide (VIP)-containing nerve fibres in the pulp was examined by double immunofluorescence. Both SP- and VIP-containing fibres entered the pulp in bundles with the blood vessels and spread throughout the pulp. In the coronal pulp, both SP- and VIP-containing nerve fibres formed networks on the walls of blood vessels, but both peptide-containing nerve fibres were not observed together in relation to vessels. There were more SP-containing fibres than VIP-containing ones. In the odontoblast layer, there were many SP-containing fibres but few VIP-containing ones. 相似文献