全文获取类型
| 收费全文 | 11835篇 |
| 免费 | 810篇 |
| 国内免费 | 42篇 |
专业分类
| 耳鼻咽喉 | 116篇 |
| 儿科学 | 414篇 |
| 妇产科学 | 269篇 |
| 基础医学 | 1366篇 |
| 口腔科学 | 266篇 |
| 临床医学 | 964篇 |
| 内科学 | 2443篇 |
| 皮肤病学 | 210篇 |
| 神经病学 | 924篇 |
| 特种医学 | 396篇 |
| 外科学 | 2441篇 |
| 综合类 | 213篇 |
| 一般理论 | 4篇 |
| 预防医学 | 655篇 |
| 眼科学 | 232篇 |
| 药学 | 872篇 |
| 中国医学 | 39篇 |
| 肿瘤学 | 863篇 |
出版年
| 2023年 | 89篇 |
| 2022年 | 64篇 |
| 2021年 | 405篇 |
| 2020年 | 266篇 |
| 2019年 | 358篇 |
| 2018年 | 473篇 |
| 2017年 | 308篇 |
| 2016年 | 382篇 |
| 2015年 | 353篇 |
| 2014年 | 540篇 |
| 2013年 | 667篇 |
| 2012年 | 1047篇 |
| 2011年 | 1002篇 |
| 2010年 | 544篇 |
| 2009年 | 503篇 |
| 2008年 | 662篇 |
| 2007年 | 699篇 |
| 2006年 | 573篇 |
| 2005年 | 516篇 |
| 2004年 | 421篇 |
| 2003年 | 331篇 |
| 2002年 | 302篇 |
| 2001年 | 171篇 |
| 2000年 | 168篇 |
| 1999年 | 152篇 |
| 1998年 | 62篇 |
| 1997年 | 65篇 |
| 1996年 | 51篇 |
| 1995年 | 68篇 |
| 1994年 | 50篇 |
| 1993年 | 39篇 |
| 1992年 | 135篇 |
| 1991年 | 113篇 |
| 1990年 | 127篇 |
| 1989年 | 108篇 |
| 1988年 | 87篇 |
| 1987年 | 91篇 |
| 1986年 | 92篇 |
| 1985年 | 82篇 |
| 1984年 | 62篇 |
| 1983年 | 47篇 |
| 1982年 | 30篇 |
| 1981年 | 34篇 |
| 1979年 | 49篇 |
| 1978年 | 31篇 |
| 1977年 | 30篇 |
| 1976年 | 22篇 |
| 1975年 | 20篇 |
| 1974年 | 33篇 |
| 1972年 | 20篇 |
排序方式： 共有10000条查询结果，搜索用时 171 毫秒
1.
2.
3.
4.
K. Young A. Aquilina T.J.S. Chesser M.L. Costa S. Hettiaratchy M.B. Kelly C.G. Moran I. Pallister M. Woodford 《Injury》2019,50(2):497-502
Aims
To assess current national practice in the management of severe open tibial fractures against national standards, using data collected by the Trauma and Audit Research Network.Materials and methods
Demographic, injury-specific, and outcome data were obtained for all grade IIIB/C fractures admitted to Major Trauma Centres in England from October 2014 to January 2016.Results
Data was available for 646 patients with recorded grade IIIB/C fractures. The male to female ratio was 2.3:1, mean age 47 years. 77% received antibiotics within 3?h of admission, 82% were debrided within 24?h. Soft tissue coverage was achieved within 72?h of admission in 71%. The amputation rate was 8.7%. 4.3% of patients required further theatre visits for infection during the index admission. The timing of antibiotics and surgery could not be correlated with returns to theatre for early infection. There were significant differences in the management and outcomes of patients aged 65 and over, with an increase in mortality and amputation rates.Conclusions
Good outcomes are reported from the management of IIIB/C fractures in Major Trauma Centres in England. Overall compliance with national standards is particularly poor in the elderly. Compliance did not appear to affect rates of returning to theatre or early infection. Appropriately applied patient reported outcome measures are needed to enhance the evidence-base for management of these injuries. 相似文献5.
Background
Regional anaesthesia for upper limb surgery is routinely performed with brachial plexus blocks. A retroclavicular brachial plexus block has recently been described, but has not been adequately compared with another approach. This randomised controlled single-blinded trial tested the hypothesis that the retroclavicular approach, when compared with the supraclavicular approach, would increase the success rate.Methods
One hundred and twenty ASA physical status 1–3 patients undergoing distal upper limb surgery were randomised to receive an ultrasound-guided retroclavicular or supraclavicular brachial plexus block with 30 mL of a 1:1 mixture of mepivacaine 1% and ropivacaine 0.5%, using a single-injection technique without needle tip repositioning. The primary outcome was block success rate 30 min after local anaesthetic injection, defined as a composite score of 14 of 16 points, inclusive of sensory and motor components. Secondary outcomes included needling time, time to first opioid request, oxycodone consumption, and pain scores (numeric rating scale, 0–10) at 24 h postoperatively.Results
Success rates were 98.3% [95% confidence interval (CI): 90.8%, 99.9%] and 98.3% [95% CI: 90.9%, 99.9%] in the supraclavicular and retroclavicular groups, respectively (P=0.99). The mean needling time was reduced in the supraclavicular group [supraclavicular: 5.0 (95% CI: 4.7, 5.4) min; retroclavicular: 6.0 (95% CI: 5.4, 6.6) min; P=0.006]. The mean time to first opioid request was similar between groups [supraclavicular: 439 (95% CI: 399, 479) min; retroclavicular: 447 (95% CI: 397, 498) min; P=0.19] as were oxycodone consumption [supraclavicular: 10.0 (95% CI: 6.5, 13.5 mg; retroclavicular: 7.9 (95% CI: 4.8, 11.0) mg; P=0.80] and pain scores at 24 h postoperatively [supraclavicular: 1.2 (95% CI: 2.1, 2.7); retroclavicular: 1.5 (95% CI: 1.6, 2.4); P=0.09].Conclusions
Ultrasound-guided retroclavicular and supraclavicular brachial plexus blocks share identical success rates, while providing similar pain relief. Reduced needling time in the supraclavicular approach is not clinically relevant.Clinical trial registration
NCT02641613. 相似文献6.
7.
Catherine Foley Namita Tundia Eric Simpson Henrique D. Teixeira Leighann Litcher-Kelly Amit Bodhani 《Current medical research and opinion》2019,35(7):1139-1148
Objectives: Atopic dermatitis (AD) is a chronic, relapsing skin condition, with signs and symptoms that impact patients’ lives and are best measured from the patient perspective. Therefore, there is a need for AD-specific questionnaires that are consistent with Food and Drug Administration guidance and best measurement practices, assessing sign and symptom severity and associated impacts, to support treatment efficacy in regulated trials. The objectives were to develop patient-reported outcome (PRO) questionnaires assessing sign and symptom severity, as well as impacts of moderate-to-severe adult AD.
Methods: A targeted literature review and meetings with clinical experts (dermatologists) were conducted to identify AD-related sign, symptom, and impact concepts. Results were harmonized and used to construct two draft PRO questionnaires: the Atopic Dermatitis Symptom Scale (ADerm-SS; 11 items) and the Atopic Dermatitis Impact Scale (ADerm-IS; 10 items). The content validity and questionnaire content were evaluated via qualitative concept elicitation/cognitive debriefing interviews with adult patients with moderate-to-severe AD.
Results: From the literature (n?=?13 articles), 13 sign and symptom and 43 impact concepts were identified, while 21 sign and symptom and 48 impacts were elicited from experts (n?=?3). During the patient interviews (n?=?15), 19 sign and symptom and 41 impact concepts were reported, the majority of which were evaluated by the ADerm-SS and ADerm-IS, thus substantiating the content of both questionnaires. Additionally, patients interpreted both questionnaires as intended by the developers.
Conclusions: The ADerm-SS and ADerm-IS can be regarded as content-valid PRO questionnaires for moderate-to-severe AD. 相似文献
8.
9.
Ramos-Fresnedo Andres Domingo Ricardo A. Vivas-Buitrago Tito Lundy Larry Trifiletti Daniel M. Jentoft Mark E. Desai Amit B. Quiñones-Hinojosa Alfredo 《Journal of neuro-oncology》2020,149(3):413-420
Journal of Neuro-Oncology - Intracranial meningiomas rarely present with multiple lesions. To the best of our knowledge, current literature regarding meningiomatosis (MM) is mostly comprised of... 相似文献