全文获取类型
收费全文 | 11094篇 |
免费 | 816篇 |
国内免费 | 41篇 |
专业分类
耳鼻咽喉 | 77篇 |
儿科学 | 294篇 |
妇产科学 | 243篇 |
基础医学 | 1896篇 |
口腔科学 | 94篇 |
临床医学 | 1024篇 |
内科学 | 2469篇 |
皮肤病学 | 187篇 |
神经病学 | 1249篇 |
特种医学 | 292篇 |
外科学 | 1119篇 |
综合类 | 49篇 |
一般理论 | 1篇 |
预防医学 | 851篇 |
眼科学 | 210篇 |
药学 | 744篇 |
中国医学 | 20篇 |
肿瘤学 | 1132篇 |
出版年
2023年 | 92篇 |
2022年 | 61篇 |
2021年 | 304篇 |
2020年 | 213篇 |
2019年 | 308篇 |
2018年 | 400篇 |
2017年 | 246篇 |
2016年 | 245篇 |
2015年 | 312篇 |
2014年 | 447篇 |
2013年 | 571篇 |
2012年 | 977篇 |
2011年 | 968篇 |
2010年 | 514篇 |
2009年 | 543篇 |
2008年 | 831篇 |
2007年 | 853篇 |
2006年 | 749篇 |
2005年 | 754篇 |
2004年 | 665篇 |
2003年 | 651篇 |
2002年 | 625篇 |
2001年 | 56篇 |
2000年 | 51篇 |
1999年 | 56篇 |
1998年 | 70篇 |
1997年 | 76篇 |
1996年 | 49篇 |
1995年 | 50篇 |
1994年 | 44篇 |
1993年 | 38篇 |
1992年 | 20篇 |
1991年 | 15篇 |
1990年 | 11篇 |
1989年 | 8篇 |
1988年 | 9篇 |
1987年 | 7篇 |
1986年 | 9篇 |
1984年 | 4篇 |
1983年 | 3篇 |
1982年 | 5篇 |
1981年 | 3篇 |
1979年 | 3篇 |
1978年 | 3篇 |
1973年 | 2篇 |
1968年 | 3篇 |
1966年 | 2篇 |
1964年 | 3篇 |
1947年 | 2篇 |
1942年 | 2篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
1.
2.
3.
4.
5.
Antonin Levy Cécile Le Péchoux Hitesh Mistry Isabelle Martel-Lafay Andrea Bezjak Delphine Lerouge Laetitia Padovani Paul Taylor Corinne Faivre-Finn 《Journal of thoracic oncology》2019,14(2):294-297
Introduction
The impact of the dose and fractionation of thoracic radiotherapy on the risk of developing brain metastasis (BM) has not been evaluated prospectively in limited stage SCLC patients receiving prophylactic cerebral irradiation (PCI).Methods
Data from patients treated with PCI from the CONVERT trial were analyzed.Results
Four hundred forty-nine of 547 patients (82%) received PCI after completion of chemoradiotherapy. Baseline brain imaging consisted of computed tomographic scans in 356 of 449 patients (79%) and magnetic resonance imaging in 83 of 449 (18%) patients. PCI was delivered to 220 of 273 participants (81%) in the twice-daily (BD) group and 229 of 270 in the once-daily (OD) group (85%; p = 0.49). Total median PCI dose was 25 Gy in both the BD and OD groups (p = 0.74). In patients who received PCI, 75 (17%) developed BM (35 [8%] in OD and 40 [9%] in BD) and 173 (39%) other extracranial progression. In the univariate analysis, gross tumor volume (GTV) was associated with an increased risk of BM (p = 0.007) or other radiological progression events (p = 0.006), whereas in a multivariate analysis both thoracic GTV (tGTV) and ECOG performance score were associated with either progression type. The median overall survival (OS) of patients treated with PCI was 29 months. In the univariate analysis of OS, PCI timing from end of chemotherapy, weight loss of more than 10%, and tGTV were prognostic factors associated with OS. In the multivariate analysis, only tGTV was associated with OS. Delay between end of chemotherapy and PCI was not associated with OS.Conclusions
Patients receiving OD or BD thoracic radiotherapy have the same risk of developing BM. Larger tumors are associated with a higher risk of BM. 相似文献6.
7.
Shane R. Stecklein Simona F. Shaitelman Gildy V. Babiera Isabelle Bedrosian Dalliah M. Black Matthew T. Ballo Isadora Arzu Eric A. Strom Valerie K. Reed Tomas Dvorak Benjamin D. Smith Wendy A. Woodward Karen E. Hoffman Pamela J. Schlembach Steve M. Kirsner Christopher L. Nelson Jinzhong Yang William Guerra Elizabeth S. Bloom 《Practical radiation oncology》2019,9(1):e4-e13
Purpose
This study aimed to prospectively characterize toxicity and cosmesis after accelerated partial breast irradiation (APBI) with 3-dimensional conformal radiation therapy (CRT) or single-entry, multilumen, intracavitary brachytherapy.Methods and materials
A total of 281 patients with pTis, pT1N0, or pT2N0 (≤3.0 cm) breast cancer treated with segmental mastectomy were prospectively enrolled from December 2008 through August 2014. APBI was delivered using 3-dimensional CRT (n = 29) or with SAVI (n = 176), Contura (n = 56), or MammoSite (n = 20) brachytherapy catheters. Patients were evaluated at protocol-specified intervals, at which time the radiation oncologist scored cosmetic outcome, toxicities, and recurrence status using a standardized template.Results
The median follow-up time is 41 months. Grade 1 seroma and fibrosis were more common with brachytherapy than with 3-dimensional CRT (50.4% vs 3.4% for seroma; P < .0001 and 66.3% vs 44.8% for fibrosis; P = .02), but grade 1 edema was more common with 3-dimensional CRT than with brachytherapy (17.2% vs 5.6%; P = .04). Grade 2 to 3 pain was more common with 3-dimensional CRT (17.2% vs 5.2%; P = .03). Actuarial 5-year rates of fair or poor radiation oncologist-reported cosmetic outcome were 9% for 3-dimensional CRT and 24% for brachytherapy (P = .13). Brachytherapy was significantly associated with inferior cosmesis on mixed model analysis (P = .003). Significant predictors of reduced risk of adverse cosmetic outcome after brachytherapy were D0.1cc (skin) ≤102%, minimum skin distance >5.1 mm, dose homogeneity index >0.54, and volume of nonconformance ≤0.89 cc. The 5-year ipsilateral breast recurrence was 4.3% for brachytherapy and 4.2% for 3-dimensional CRT APBI patients (P = .95).Conclusions
Brachytherapy APBI is associated with higher rates of grade 1 fibrosis and seroma than 3-dimensional CRT but lower rates of grade 1 edema and grade 2 to 3 pain than 3-dimensional CRT. Rates of radiation oncologist-reported fair or poor cosmetic outcomes are higher with brachytherapy. We identified dosimetric parameters that predict reduced risk of adverse cosmetic outcome after brachytherapy-based APBI. Ipsilateral breast recurrence was equivalent for brachytherapy and 3-dimensional CRT. 相似文献8.
Brnice Le Dieu‐Lugon Nicolas Dupr Lou Legouez Philippe Leroux Bruno J. Gonzalez Stphane Marret Isabelle Leroux‐Nicollet Carine Cleren 《The European journal of neuroscience》2020,52(1):2560-2574
Preterm birth is a high‐risk factor for the development of gray and white matter abnormalities, referred to as “encephalopathy of prematurity,” that may lead to life‐long motor, cognitive, and behavioral impairments. The prevalence and clinical outcomes of encephalopathy of prematurity differ between sexes, and elucidating the underlying biological basis has become a high‐priority challenge. Human studies are often limited to assessment of brain region volumes by MRI, which does not provide much information about the underlying mechanisms of lesions related to very preterm birth. However, models using KO mice or pharmacological manipulations in rodents allow relevant observations to help clarify the mechanisms of injury sustaining sex‐differential vulnerability. This review focuses on data obtained from mice aged P1–P5 or rats aged P3 when submitted to cerebral damage such as hypoxia‐ischemia, as their brain lesions share similarities with lesion patterns occurring in very preterm human brain, before 32 gestational weeks. We first report data on the mechanisms underlying the development of sexual brain dimorphism in rodent, focusing on the hippocampus. In the second part, we describe sex specificities of rodent models of encephalopathy of prematurity (RMEP), focusing on mechanisms underlying differences in hippocampal vulnerability. Finally, we discuss the relevance of these RMEP. Together, this review highlights the need to systematically search for potential effects of sex when studying the mechanisms underlying deficits in RMEP in order to design effective sex‐specific medical interventions in human preterms. 相似文献
9.