收费全文 | 22431篇 |
免费 | 1113篇 |
国内免费 | 102篇 |
耳鼻咽喉 | 231篇 |
儿科学 | 453篇 |
妇产科学 | 311篇 |
基础医学 | 3207篇 |
口腔科学 | 490篇 |
临床医学 | 1606篇 |
内科学 | 5725篇 |
皮肤病学 | 386篇 |
神经病学 | 1935篇 |
特种医学 | 781篇 |
外科学 | 2989篇 |
综合类 | 108篇 |
一般理论 | 3篇 |
预防医学 | 652篇 |
眼科学 | 589篇 |
药学 | 1793篇 |
中国医学 | 93篇 |
肿瘤学 | 2294篇 |
2023年 | 116篇 |
2021年 | 336篇 |
2020年 | 189篇 |
2019年 | 325篇 |
2018年 | 386篇 |
2017年 | 305篇 |
2016年 | 375篇 |
2015年 | 402篇 |
2014年 | 514篇 |
2013年 | 643篇 |
2012年 | 1036篇 |
2011年 | 1167篇 |
2010年 | 642篇 |
2009年 | 555篇 |
2008年 | 1032篇 |
2007年 | 1122篇 |
2006年 | 1015篇 |
2005年 | 1150篇 |
2004年 | 1066篇 |
2003年 | 1023篇 |
2002年 | 961篇 |
2001年 | 729篇 |
2000年 | 755篇 |
1999年 | 701篇 |
1998年 | 253篇 |
1997年 | 207篇 |
1996年 | 234篇 |
1995年 | 200篇 |
1994年 | 204篇 |
1993年 | 160篇 |
1992年 | 534篇 |
1991年 | 538篇 |
1990年 | 500篇 |
1989年 | 472篇 |
1988年 | 381篇 |
1987年 | 347篇 |
1986年 | 364篇 |
1985年 | 338篇 |
1984年 | 238篇 |
1983年 | 208篇 |
1982年 | 113篇 |
1981年 | 98篇 |
1980年 | 108篇 |
1979年 | 187篇 |
1978年 | 122篇 |
1977年 | 113篇 |
1974年 | 106篇 |
1972年 | 106篇 |
1969年 | 100篇 |
1968年 | 101篇 |
- Panitumumab monotherapy showed favorable efficacy and feasibility in the treatment of frail or elderly patients with RAS wild‐type unresectable colorectal cancer.
- It is especially effective for left‐sided tumors; therefore, panitumumab as first‐line treatment could be an additional therapeutic option for frail elderly patients, particularly in those who are unsuitable for upfront oxaliplatin‐based or irinotecan‐based combination regimens.
Methods: Individuals who visited the outpatient clinic or were admitted to the palliative care unit were eligible. Patients with a performance status of 4 and/or those unable to complete questionnaires were excluded. PA was evaluated using a bioanalyzer device. The correlation coefficient between PA and the variables of interest was analyzed.
Results: A total of 102 patients were analyzed. PA was weakly correlated with age (ρ = ?0.22), performance status (ρ = ?0.30), functional well-being (ρ?=?0.20), anorexia/cachexia subscale (ρ?=?0.22), and Functional Assessment of Anorexia/Cachexia Therapy trial outcome index (ρ?=?0.26). PA was also correlated with fluid retention (ρ = ?0.34) and albumin (ρ?=?0.32), C-reactive protein (ρ = ?0.31), and hemoglobin (ρ?=?0.41) levels. Sub-analysis stratified according to sex revealed that males demonstrated the same results; however, female sex demonstrated a correlation between PA and social well-being (ρ = ?0.43).
Conclusions: PA was correlated with physical condition, but not with psychological well-being. 相似文献
Background
There were few studies assessed the postoperative sarcopenia in patients with cancers. The objective of present study was to assess whether postoperative development of sarcopenia could predict a poor prognosis in patients with adenocarcinoma of esophagogastric junction, (AEG) and upper gastric cancer (UGC).Methods
Patients with AEG and UGC who were judged as non-sarcopenic before surgery were reassessed the presence of postoperative development of sarcopenia 6 months after surgery. Patients were divided into the development group or non-development group, and clinicopathological factors and prognosis between these two groups were analyzed.Results
The 5-year overall survival rates were significantly poorer in the development group than non-development group (68.0% vs. 92.6%, P?=?0.0118). Multivariate analyses showed that postoperative development of sarcopenia was an independent prognostic factor for poor overall survival (P?=?0.0237).Conclusions
Postoperative development of sarcopenia was associated with a poor prognosis in patients with AEG and UGC. 相似文献Methods: Ten-week-old male Apo-E KO mice were randomly assigned a regular high-fat diet, a high-fat diet with 0.5% α-glucosyl hesperidin, or a high-fat diet with 0.1% water-dispersible hesperetin for 12?weeks. Measurement of plasma total cholesterol levels, histological staining of aortic root, and immunohistochemistry for macrophages were performed to evaluate atherosclerotic plaque formation. Vascular reactivity of mouse aortic rings was also measured.
Results: Both α-glucosyl hesperidin and water-dispersible hesperetin reduced plasma total cholesterol level. They also reduced plaque formation area, adipose deposition, and macrophage infiltration into atherosclerotic lesion. Vascular-endothelium-dependent relaxation in response to acetylcholine was improved in both experimental diet groups compared to the high-fat diet group.
Conclusions: Our study suggests that both α-glucosyl hesperidin and water-dispersible hesperetin exert protective effects on atherosclerotic progression in Apo-E KO mice because they exhibit hypolipidemic activity, reduce inflammation through macrophages, and prevent endothelial dysfunction. 相似文献