全文获取类型
收费全文 | 1645篇 |
免费 | 81篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 67篇 |
妇产科学 | 12篇 |
基础医学 | 170篇 |
口腔科学 | 30篇 |
临床医学 | 114篇 |
内科学 | 546篇 |
皮肤病学 | 48篇 |
神经病学 | 118篇 |
特种医学 | 40篇 |
外科学 | 274篇 |
综合类 | 9篇 |
预防医学 | 54篇 |
眼科学 | 11篇 |
药学 | 68篇 |
中国医学 | 2篇 |
肿瘤学 | 162篇 |
出版年
2023年 | 10篇 |
2021年 | 24篇 |
2020年 | 18篇 |
2019年 | 27篇 |
2018年 | 33篇 |
2017年 | 23篇 |
2016年 | 25篇 |
2015年 | 14篇 |
2014年 | 32篇 |
2013年 | 43篇 |
2012年 | 52篇 |
2011年 | 53篇 |
2010年 | 37篇 |
2009年 | 26篇 |
2008年 | 61篇 |
2007年 | 59篇 |
2006年 | 60篇 |
2005年 | 90篇 |
2004年 | 72篇 |
2003年 | 55篇 |
2002年 | 70篇 |
2001年 | 76篇 |
2000年 | 95篇 |
1999年 | 71篇 |
1998年 | 19篇 |
1997年 | 10篇 |
1996年 | 10篇 |
1995年 | 18篇 |
1994年 | 18篇 |
1993年 | 17篇 |
1992年 | 40篇 |
1991年 | 65篇 |
1990年 | 48篇 |
1989年 | 34篇 |
1988年 | 41篇 |
1987年 | 27篇 |
1986年 | 31篇 |
1985年 | 32篇 |
1984年 | 17篇 |
1983年 | 19篇 |
1979年 | 9篇 |
1978年 | 10篇 |
1975年 | 14篇 |
1974年 | 8篇 |
1973年 | 11篇 |
1971年 | 16篇 |
1970年 | 15篇 |
1969年 | 9篇 |
1967年 | 7篇 |
1966年 | 7篇 |
排序方式: 共有1729条查询结果,搜索用时 15 毫秒
1.
Masaki Shiota Eiji Kashiwagi Tomohiko Murakami Ario Takeuchi Kenjiro Imada Junichi Inokuchi Katsunori Tatsugami Masatoshi Eto 《Urologic oncology》2019,37(3):180.e19-180.e24
Purpose
Currently, several therapeutic options for castration-resistant prostate cancer (CRPC) are available, for which predictive biomarkers have not been established. Therefore, we aimed to reveal the association between pretreatment serum testosterone level and antitumor outcomes when treated with androgen receptor axis-targeting agents and taxane chemotherapies for CRPC.Patients and methods
The present study included Japanese patients with metastatic prostate cancer whose serum testosterone levels during androgen-deprivation therapy were available. The antitumor outcomes when treated with enzalutamide, abiraterone, docetaxel, and cabazitaxel with clinicopathological parameters including serum testosterone levels during androgen-deprivation therapy, as well as prognoses including progression-free survival and overall survival, were examined.Results
Progression-free survival among men with higher serum testosterone level was superior to that among men with lower serum testosterone level when treated with enzalutamide. On the contrary, progression-free survival and overall survival among men with higher serum testosterone level were significantly inferior to those among men with lower serum testosterone level when treated with docetaxel and cabazitaxel, respectively.Conclusions
The present study indicated distinct prognostic values of serum testosterone level when treated with androgen receptor axis-targeting agent and taxane chemotherapy for CRPC, suggesting that serum testosterone level may be useful predictive biomarker to navigate the appropriate therapy in patients with CRPC. 相似文献2.
3.
Yasushi Sawayama Hidehiro Itonaga Takuya Fukushima Nobuaki Nakano Hiroshi Fujiwara Atae Utsunomiya Takahiro Fukuda Toshihiro Miyamoto Tetsuya Eto Kaname Miyashita Hirohisa Nakamae Masao Ogata Atsushi Yamanoha Yasuhiko Miyazaki Junya Kanda Yoshiko Atsuta Koji Kato ATL Working Group of the Japan Society for Hematopoietic Cell Transplantation 《American journal of hematology》2019,94(5):E143-E146
4.
5.
6.
The reaction of grafted skin to irradiation was studied in the rat and the optimum time for irradiation postoperatively was determined. There was a close correlation between the radiosensitivity and the vascularity of the graft and its recipient bed. Grafts showed different reactions depending on the time of irradiation after grafting. Those in the early hypovascular stage showed reactions similar to those of normal control skin. Severe reactions were observed in the hypervascular stage. Grafts in the late hypovascular stage showed more moderate reactions. 相似文献
7.
OBJECTIVE: The clinical usefulness of therapeutic drug monitoring (TDM) for haloperidol using blood samples has to be validated. Despite the potential advantage of TDM using saliva, there are few reports comparing drug levels in saliva and blood. Additionally, the relation between haloperidol levels in saliva and brain, the target organ of this drug, has not been reported. We compared haloperidol levels in rat submandibular saliva, plasma and brain. DESIGN: Haloperidol was administered through the femoral vein (0.25 mg/kg). Submandibular saliva was collected 30 min after drug administration. To stimulate secretion, the chorda (parasympathetic) and superior cervical ganglion (sympathetic) were electrically stimulated, and pilocarpine was administered. The concentration of haloperidol in saliva, plasma and brain homogenate was determined. RESULTS: Haloperidol levels in saliva elicited by any stimuli significantly correlated with levels in the brain and plasma. The correlation of haloperidol between saliva and brain was higher than that between plasma and brain. Immunohistochemistry showed that haloperidol was secreted from striated duct cells within the submandibular gland. CONCLUSION: These results suggested that haloperidol was specifically secreted from the striated duct system, and that salivary drug levels reflect the levels in the brain more precisely than plasma. 相似文献
8.
9.
10.
Saito M Eto M Nitta H Kanda Y Shigeto M Nakayama K Tawaramoto K Kawasaki F Kamei S Kohara K Matsuda M Matsuki M Kaku K 《Diabetes care》2004,27(6):1276-1280
OBJECTIVE: The aim of this study was to investigate the effect of apolipoprotein (apo)E4 allele on plasma LDL cholesterol response to calorie-restricted diet therapy in type 2 diabetic patients. RESEARCH DESIGN AND METHODS: Twenty-four diabetic patients with the apoE3/3 genotype and 11 diabetic patients with the apoE4/3 genotype were recruited. Participants were hospitalized for calorie-restricted diet therapy (25.0 kcal. kg body wt(-1). day(-1)) for 14 days. Body weight, fasting plasma glucose (FPG) levels, and plasma lipid levels on hospital days 1 and 14 were compared between the two apoE genotype groups. RESULTS: There were no significant differences in baseline FPG levels, HbA(1c) levels, BMI, and plasma levels of total cholesterol, triglyceride, and HDL cholesterol between the two apoE genotype groups, but baseline plasma levels of LDL cholesterol were significantly higher in the apoE4/3 group than in the apoE3/3 group. Body weight decreased slightly and FPG levels decreased significantly after diet therapy in both apoE genotype groups. In the apoE3/3 group, only plasma levels of triglyceride decreased significantly after diet therapy, whereas in the apoE4/3 group, plasma levels of triglyceride, total cholesterol, and LDL cholesterol decreased significantly after diet therapy. The decrease (percentage of change) in total cholesterol (-16.3 vs. -6.6%) and LDL cholesterol (-15.6 vs. -0.7%) after diet therapy was significantly greater in the apoE4/3 group than in the apoE3/3 group. CONCLUSIONS: Calorie-restricted diet therapy is more effective in reducing plasma LDL cholesterol in type 2 diabetic patients with the apoE4 allele. 相似文献