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Mark A. Espeland PhD Jose A. Luchsinger MD MPH Rebecca H. Neiberg MS Owen Carmichael PhD Paul J. Laurienti PhD Xavier Pi‐Sunyer MD Rena R. Wing PhD Delilah Cook CCRP Edward Horton MD Ramon Casanova PhD Kirk Erickson PhD R. Nick Bryan MD the Action for Health in Diabetes Brain Magnetic Resonance Imaging Research Group 《Journal of the American Geriatrics Society》2018,66(1):120-126
Objectives
To determine whether long‐term behavioral intervention targeting weight loss through increased physical activity and reduced caloric intake would alter cerebral blood flow (CBF ) in individuals with type 2 diabetes mellitus.Design
Postrandomization assessment of CBF.Setting
Action for Health in Diabetes multicenter randomized controlled clinical trial.Participants
Individuals with type 2 diabetes mellitus who were overweight or obese and aged 45 to 76 (N = 310).Interventions
A multidomain intensive lifestyle intervention (ILI ) to induce weight loss and increase physical activity for 8 to 11 years or diabetes support and education (DSE ), a control condition.Measurements
Participants underwent cognitive assessment and standardized brain magnetic resonance imaging (MRI ) (3.0 Tesla) to assess CBF an average of 10.4 years after randomization.Results
Weight changes from baseline to time of MRI averaged ?6.2% for ILI and ?2.8% for DSE (P < .001), and increases in self‐reported moderate or intense physical activity averaged 444.3 kcal/wk for ILI and 114.8 kcal/wk for DSE (P = .03). Overall mean CBF was 6% greater for ILI than DSE (P = .04), with the largest mean differences between ILI and DSE in the limbic region (3.39 mL /100 g per minute, 95% confidence interval (CI ) = 0.07–6.70 mL /100 g per minute) and occipital lobes (3.52 mL /100 g per minute, 95% CI = 0.20–6.84 mL /100 g per minute). In ILI , greater CBF was associated with greater decreases in weight and greater increases in physical activity. The relationship between CBF and scores on a composite measure of cognitive function varied between intervention groups (P = .02).Conclusions
Long‐term weight loss intervention in overweight and obese adults with type 2 diabetes mellitus is associated with greater CBF .3.
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Phase 1b study of pasireotide,everolimus, and selective internal radioembolization therapy for unresectable neuroendocrine tumors with hepatic metastases 下载免费PDF全文
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Karen L. Reckamp MD Carolyn E. Behrendt PhD Thomas P. Slavin MD Stacy W. Gray MD Danielle K. Castillo BS Marianna Koczywas MD Mihaela C. Cristea MD Kirsten M. Babski BS CCRP Donna Stearns BS Catherine A. Marcum APN AGACNP-BC AGN-BC ACGN Yenni P. Rodriguez MD Amie J. Hass MSN ARNP Mary M. Vecchio APNC OCN CTTS Pamela Mora MD Aleck E. Cervantes BS Sharon R. Sand MA Rosa M. Mejia BA Terrence C. Tsou BS Ravi Salgia MD PhD Jeffrey N. Weitzel MD 《Cancer》2021,127(15):2801-2806
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A novel retinal biomarker for Parkinson's disease: Quantifying the foveal pit with optical coherence tomography 下载免费PDF全文
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Ian S. Hagemann MD PhD Siddhartha Devarakonda MD Christina M. Lockwood PhD David H. Spencer MD PhD Kalin Guebert MS CCRP Andrew J. Bredemeyer PhD Hussam Al‐Kateb MS PhD TuDung T. Nguyen MD PhD Eric J. Duncavage MD Catherine E. Cottrell PhD Shashikant Kulkarni MS PhD Rakesh Nagarajan MD PhD Karen Seibert PhD Maria Baggstrom MD Saiama N. Waqar MD John D. Pfeifer MD PhD Daniel Morgensztern MD Ramaswamy Govindan MD 《Cancer》2015,121(4):631-639