Effect of health consciousness behavior and health-promoting behavior on the quality of life in elders in South Korea

[Purpose] This study aimed to examine the correlation between health consciousness behavior and health-promoting behavior and quality of life, and to examine the factors affecting the quality of life for elders in South Korea. [Participants and Methods] This study is a cross-sectional study. A total of 191 respondents were selected through convenient sampling. Data were collected with a self-reported questionnaire from August 20 to September 20, 2019. [Results] Differences in health consciousness behavior and health-promoting behavior according to general characteristics and health behavior were as follows. Health consciousness behavior was significantly different according to gender, age, education, religion, occupation, exercise, smoking, drinking, health checkup. Health health-promoting behavior was significantly different according to gender, age, education, stress, health status, drinking. Quality of life was significantly different according to education, stress, health status, exercise, drinking. There was a positive correlation between health-promoting behavior and quality of life. Fifty three point zero percent of the variance in quality of life was explained by health-promoting behavior, health status and exercise. [Conclusion] The findings of this study may be useful in understanding the quality of life for elders and developing more specific programs about health-promoting behavior programs and health status and exercise management strategy is required.Key words: Health behavior, Health promotion, Quality of life     

Second Victim Experience and Perception Discordance of the Colonoscopic Perforation

Digestive Diseases and Sciences - Perforation is the most serious adverse event of colonoscopy, but rarely considered from the view of colonoscopists’ second victim experience and perception...     

Direct insertion of an ultra‐slim upper endoscope for cholangioscopy in patients undergoing choledochoduodenostomy

Direct peroral cholangioscopy (POC) using an ultra‐slim upper endoscope is one modality of POC for intraductal endoscopic evaluation and treatment of the bile duct. Choledochoduodenostomy (CDS) is one modality of biliary bypass surgery that provides a new route to the bile duct. We carried out direct POC using an ultra‐slim upper endoscope without the use of accessories in 10 patients (four sump syndromes, three bile duct strictures and three intrahepatic duct stones) previously undergoing surgical CDS. Direct POC was successful in all patients. The use of an intraductal balloon catheter was required in one patient for advancement of the endoscope into the bile duct. Distal bile ducts with sump syndromes were cleared using baskets and water irrigation under direct POC. Cholangiocarcinoma was diagnosed in one patient with hilar bile duct stricture after cholangioscopic evaluation and a targeting forceps biopsy under direct POC. Intrahepatic duct stones were successfully extracted after intraductal fragmentation under direct POC. Oozing bleeding occurred during intraductal lithotripsy but stopped spontaneously. Direct POC using an ultra‐slim upper endoscope without the assistance of accessories can easily be carried out in patients undergoing CDS.     

GalNAc-T14 promotes metastasis through Wnt dependent HOXB9 expression in lung adenocarcinoma

While metastasis, the main cause of lung cancer-related death, has been extensively studied, the underlying molecular mechanism remains unclear. A previous clinicogenomic study revealed that expression of N-acetylgalactosaminyltransferase (GalNAc-T14), is highly inversely correlated with recurrence-free survival in those with non-small cell lung cancer (NSCLC). However, the underlying molecular mechanism(s) has not been determined. Here, we showed that GalNAc-T14 expression was positively associated with the invasive phenotype. Microarray and biochemical analyses revealed that HOXB9, the expression of which was increased in a GalNAc-T14-dependent manner, played an important role in metastasis. GalNAc-T14 increased the sensitivity of the WNT response and increased the stability of the β-catenin protein, leading to induced expression of HOXB9 and acquisition of an invasive phenotype. Pharmacological inhibition of β-catenin in GalNAc-T14-expressing cancer cells suppressed HOXB9 expression and invasion. A meta-analysis of clinical genomics data revealed that expression of GalNAc-T14 or HOXB9 was strongly correlated with reduced recurrence-free survival and increased hazard risk, suggesting that targeting β-catenin within the GalNAc-T14/WNT/HOXB9 axis may be a novel therapeutic approach to inhibit metastasis in NSCLC.