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Aleksander Ku Mikoaj Radziszewski Aleksandra Glina Konrad Szymaski Beata Jurecka‐Lubieniecka Edyta Pawlak‐Adamska Dorota Kula Natalia Wawrusiewicz‐Kurylonek Joanna Ku Piotr Mikiewicz Rafa Poski Marek Bolanowski Jacek Daroszewski Barbara Jarzb Artur Bossowski Tomasz Bednarczuk 《Clinical endocrinology》2019,90(2):320-327
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Izabela Szczygielska El?bieta Hernik Ma?gorzata Kwiatkowska Lidia Rutkowska-Sak Beata Ko?odziejczyk Agnieszka Gazda 《Reumatologia》2015,53(2):56-60
Objectives
Protective vaccinations are the most effective method of prevention of type B virus hepatitis. The aim of the study was to determine whether in children receiving immunosuppressive therapy due to inflammatory systemic connective tissue diseases the protective concentration of the anti-HBs antibodies produced after vaccination against type B virus hepatitis in infancy is maintained.Material and methods
The concentration of anti-HBs antibodies was assessed in the sera of 50 children with inflammatory connective tissue diseases – 37 girls (74%) and 13 boys (26%), aged 1.5–17.5 years – during the immunosuppressive treatment, which lasted at least 6 months. The control group consisted of 50 healthy children – 28 girls (56%) and 22 boys (44%) aged 2–17 years. All children were vaccinated in infancy with Engerix B vaccine according to the 0–1–6 months schedule. The antibody concentration of ≥ 10 mIU/ml in patients is regarded as protective.Results
No protective antibody concentrations were found in 25 cases (50%) in the group of diseased children and only in 2 children in the control group (4%).Conclusions
The concentration of vaccine-induced antibodies should be assessed in children with inflammatory systemic connective tissue diseases and, in case of the absence of a protective concentration, revaccination should be started. The use of glucocorticosteroids, synthetic and biological disease-modifying antirheumatic drugs is no contraindication to vaccination against hepatitis B. 相似文献9.
Marcus Pohl Qixian Shan Thomas Petsch Beata Styp-Rekowska Patricia Matthey Markus Bleich Sebastian Bachmann Franziska Theilig 《Journal of the American Society of Nephrology : JASN》2015,26(6):1269-1278
Transepithelial water flow across the renal proximal tubule is mediated predominantly by aquaporin-1 (AQP1). Along this nephron segment, luminal delivery and transepithelial reabsorption are directly coupled, a phenomenon called glomerulotubular balance. We hypothesized that the surface expression of AQP1 is regulated by fluid shear stress, contributing to this effect. Consistent with this finding, we found that the abundance of AQP1 in brush border apical and basolateral membranes was augmented >2-fold by increasing luminal perfusion rates in isolated, microperfused proximal tubules for 15 minutes. Mouse kidneys with diminished endocytosis caused by a conditional deletion of megalin or the chloride channel ClC-5 had constitutively enhanced AQP1 abundance in the proximal tubule brush border membrane. In AQP1-transfected, cultured proximal tubule cells, fluid shear stress or the addition of cyclic nucleotides enhanced AQP1 surface expression and concomitantly diminished its ubiquitination. These effects were also associated with an elevated osmotic water permeability. In sum, we have shown that luminal surface expression of AQP1 in the proximal tubule brush border membrane is regulated in response to flow. Cellular trafficking, endocytosis, an intact endosomal compartment, and controlled protein stability are the likely prerequisites for AQP1 activation by enhanced tubular fluid shear stress, serving to maintain glomerulotubular balance. 相似文献
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Agata Zamecznik Beata Kierzkowska Katarzyna Niewiadomska-Jarosik Jarosław Rycaj Beata Chodór Jerzy Stańczyk 《Pediatria polska》2014
Cardiomyopathies are a group of rare diseases of a myocardium in a pediatric population which affect 1–1.5 cases per 100 000 children. Restrictive cardiomyopathy (RCM) is the least common type, which constitutes 2–5% of all cardiomyopathies. RCM is characterized by a diastolic dysfunction which is a result of an increased stiffness of the ventricular myocardium with a normal systolic function. Differential diagnosis should include especially constrictive pericarditis. Because of a poor prognosis, it is important to diagnose patients as soon as possible and to early qualify them for a heart transplantation. 相似文献