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目的 探讨宫颈癌患者 Kruppel 样因子 6(KLF6),p21 蛋白表达水平与病理特征及化疗敏感性的相关性。方法 回顾性分析 2016 年 1 月 ~2018 年 12 月接受化疗的 40 例宫颈癌患者,化疗结束后根据化疗效果将患者分为化疗敏感组(CR+PR)、化疗抵抗组(SD+PD)。采用免疫组化检测宫颈癌组织 KLF6,p21 蛋白的表达,分析其与临床病理特征、化疗敏感性及总生存期(OS)的关系。结果 宫颈癌中 KLF6,p21 蛋白阳性率与病理分期、肿瘤直径、分化类型及化疗敏感性相关(χ 2 =2.14~5.74,均 P<0.05)。KLF6+/p21- 者 ORR 为 85.71%,显著高于非 KLF6+/p21- 者 42.11%(χ 2 =8.33,P<0.05)。宫颈癌患者的中位 OS 为 11.20 个月(95%CI: 9.73~12.71),其中 KLF6 阳性者中位 OS 为 11.90个月(95%CI: 10.81~12.99),显著高于阴性表达者 9.20 个月(95%CI: 9.05~9.35);p21 蛋白阳性者中位 OS 为 9.14 个月(95%CI: 8.26~10.22),显著低于 p21 阴性表达者 11.62 个月(95%CI: 9.63~13.58)(χ 2 =11.50,6.23,均 P<0.05)。结论 宫颈癌患者 KLF6,p21 表达水平与其临床病理特征相关。KLF6 高表达、p21 低表达者化疗敏感性高,且预后更好,可作为预后、个体化治疗方案选择的评价指标。  相似文献   
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目的 探讨支气管哮喘患儿外周血中 2 型固有免疫细胞(type2 innate lymphoid cells ILC2)和 Th2 型细胞相关因子水平变化及其临床意义。方法 选取 2019 年 1 月 ~2020 年 5 月在宝鸡高新人民医院确诊的 67 例急性发作期支气管哮喘患儿作为研究对象,根据发病严重程度分为重度 - 危重组 23 例和轻 - 中度组 44 例;并选取同期健康体检的 45例儿童作为对照组。检测两组血清 ILC2 细胞比例和 IL-4,IL-5,IL-10 和 IL-13 水平,记录两组肺功能指标:第一秒用力呼气量(FEV1)、用力肺活量(FVC)及最大呼气峰流速(PEF);并分析 ILC2 细胞比例和 IL-4,IL-5,IL-10 和IL-13 水平与肺功能指标的相关性。结果 支气管哮喘组患儿外周血 ILC2 细胞比例及 IL-4,IL-5 和 IL-13 水平明显高于对照组,差异均有统计学意义(F=24.419~209.627,均 P<0.001);IL-10 水平及肺功能指标 FVC,FEV1 和 PEF 明显低于对照组,差异均有统计学意义(F=80.826~298.942,均 P<0.001)。重度 - 危重组支气管哮喘患儿外周血 ILC2 细胞比例和 IL-4,IL-5,IL-10 和 IL-13 水平及肺功能指标变化较轻 - 中度组更为显著,差异均有统计学意义(t=1.990~7.848,P 均 <0.05)。支气管哮喘患儿外周血 ILC2 细胞比例及 IL-4,IL-5 和 IL-13 水平与 FVC,FEV1 和 PEF 值呈显著负相关,差异均有统计学意义(r=0.564~0.712,均 P<0.01);IL-10 水平与 FVC,FEV1 和 PEF 值呈显著正相关,差异均有统计学意义(r=0.537~0.603,均 P<0.01)。结论 急性发作期支气管哮喘患儿外周血 ILC2 细胞比例及 Th2 型细胞相关因子水平明显升高或降低,与哮喘患儿肺功能及病情严重程度显著相关,对其进行检测有助于评估支气管哮喘患儿病情程度,为临床提供理论指导。  相似文献   
4.
Clinical Rheumatology - Since December 2019, the pandemic caused by coronavirus disease 2019 (COVID-19) raises a real public health problem. COVID-19 appeared in Wuhan (Hubei province) in China....  相似文献   
5.
Obesity has generated significant worries amongst health policy makers and has obtained increased attention in health care. Obesity is unanimously defined as a disease in the health care and health policy literature. However, there are pragmatic and not principled reasons for this. This warrants an analysis of obesity according to standard conceptions of disease in the literature of philosophy of medicine. According to theories and definitions of disease referring to (abnormal functioning of) internal processes, obesity is not a disease. Obesity undoubtedly can result in disease, making it a risk factor for disease, but not a disease per se. According to several social conceptions of disease, however, obesity clearly is a disease. Obesity can conflict with aesthetic, moral, or other social norms. Making obesity a “social disease” may very well be a wise health policy, assuring and improving population health, especially if we address the social determinants of obesity, such as the food supply and marketing system. However, applying biomedical solutions to social problems may also have severe side effects. It can result in medicalization and enhance stigmatization and discrimination of persons based on appearance or behavior. Approaching social problems with biomedical means may also serve commercial and professionals’ interests more than the health and welfare of individuals; it may make quick fix medical solutions halt more sustainable structural solutions. This urges health insurers, health care professionals, and health policy makers to be cautious. Especially if we want to help and respect persons that we classify and treat as obese.  相似文献   
6.
Huntington's disease (HD), an autosomal dominantly inherited polyglutamine or CAG repeat disease along with somatomotor, oculomotor, psychiatric and cognitive symptoms, presents clinically with impairments of elementary and complex visual functions as well as altered visual‐evoked potentials (VEPs). Previous volumetric and pathoanatomical post‐mortem investigations pointed to an involvement of Brodmann's primary visual area 17 (BA17) in HD. Because the involvement of BA17 could be interpreted as an early onset brain neurodegeneration, we further characterized this potential primary cortical site of HD‐related neurodegeneration neuropathologically and performed an unbiased estimation of the absolute nerve cell number in thick gallocyanin‐stained frontoparallel tissue sections through the striate area of seven control individuals and seven HD patients using Cavalieri's principle for volume and the optical disector for nerve and glial cell density estimations. This investigation showed a reduction of the estimated absolute nerve cell number of BA17 in the HD patients (71 044 037 ± 12 740 515 nerve cells) of 32% in comparison with the control individuals (104 075 067 ± 9 424 491 nerve cells) (Mann–Whitney U‐test; P < 0.001). Additional pathoanatomical studies showed that nerve cell loss was most prominent in the outer pyramidal layer III, the inner granular layers IVa and IVc as well as in the multiform layer VI of BA17 of the HD patients. Our neuropathological results in BA17 confirm and extend previous post‐mortem, biochemical and in vivo neuroradiological HD findings and offer suitable explanations for the elementary and complex visual dysfunctions, as well as for the altered VEP observed in HD patients.  相似文献   
7.
Clinical manifestations of human papillomavirus (HPV) infection in the head and neck can range from benign lesions, which are the most frequent, to malignant lesions. The prevalence of head and neck cancer is increasing, despite currently decreasing trends in known risk factors such as smoking and alcohol use. A new patient profile has appeared in recent practice: most frequently a middle‐aged male patient who does not smoke or drink alcohol, is sexually active (possibly having multiple partners), and presents with oral or cervicofacial lesions requiring diagnosis and treatment. Another risk factor that should be considered in these patients is HPV infection. The association of oral potentially malignant disorders (OPMD) with HPV is a challenge for the medical practitioner. The gold standard for diagnosis is histopathological examination, which can also yield evidence suggesting HPV infection. Determination of the viral genotype provides additional data for assessing the oncological risk of an HPV infection. Treatment of these patients is aimed at removing the lesions, in association or not with antiviral treatment and recurrence control. Clin. Anat. 28:1002–1007, 2015. © 2015 Wiley Periodicals, Inc.  相似文献   
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9.

Background

Children have a statutory right to a smoke-free environment, and tobacco control advocates are now considering regulation of smoking behavior in the private sphere. The Norwegian Institute of Public Health has investigated the support for a ban on smoking in cars with children compared to other possible extensions of the tobacco act among the Norwegian public.

Material and methods

A nationwide representative survey (CAWI) of 5543 participants was conducted in 2014–2015. Respondents were asked to consider several possible new tobacco control measures, through selfreported ranking on 5-point scales for each measure. Multiple logistic regression models were applied to control for confounders (i.a. smoking behavior) for the tendency to state full support.

Results

A majority (78 % of all respondents, 61.8% of daily smokers) supported a proposal prohibiting smoking in cars when children are present. This proposal received substantially more support than bans on private balconies, in parks and at public transport stops and work entrances. Full support for the latter proposals varied between 39.9% and 58.1% (between 2.7% and 16.8% among smokers). Differences by smoking status were maintained after multiple controls.

Interpretation

The strong endorsement of the proposal (also provided by the majority of current smokers) suggests high legitimacy and compliance, which means that an implementation could be introduced without serious enforcement problems.  相似文献   
10.
目的 对血清甲状腺球蛋白免疫复合物 (thyroglobulin circulating immune complex, Tg-CIC) 中抗甲状腺球蛋白抗体 (anti-thyroglobulin antibody, Tg-Ab) 含量检测,探讨 Tg-CIC 在甲状腺疾病中的临床以及流行病学意义。方法 收集甲状腺疾病患者血清标本 187 例,每例血清标本分为两组 ( 实验组和空白对照组 ),采用免疫复合物解离专利技术对甲状腺疾病患者血清标本 Tg-CIC 进行分离、解离,通过检测 Tg-CIC 解离后的 Tg-Ab 含量来间接反映甲状腺疾病患者血清中Tg-CIC 水平,按照不同的甲状腺疾病进行分组并对实验结果分析讨论。结果 不同甲状腺患者血清中 Tg-CIC 总阳性率达 92.51%,不同甲状腺疾病血清中 Tg-CIC 的阳性率差异无统计学意义 (χ?=2.917, P>0.05)。不同甲状腺疾病患者间血清游离 Tg-Ab 含量差异无统计学意义 (H=3.882, P>0.05),不同甲状腺疾病患者间血清 CIC 中 Tg-Ab 含量差异无统计学意义(H=5.5842, P>0.05)。不同甲状腺疾病患者中,甲状腺功能亢进、甲状腺炎以及甲状腺结节患者血清游离 Tg-Ab 的含量与血清 CIC 中的 Tg-Ab 含量呈正相关 (P<0.05),甲状腺功能减退、甲状腺肿瘤患者血清游离 Tg-Ab 的含量与血清 CIC 中的Tg-Ab 含量不相关 (P>0.05)。结论 在甲状腺疾病患者血清中,大部分可检出 Tg-CIC,与疾病类型无关。而甲状腺疾病患者中,甲状腺功能亢进、甲状腺炎以及甲状腺结节患者血清游离 Tg-Ab 含量与血清 CIC 中 Tg-Ab 含量存在相关性,为我们进一步了解 Tg-CIC 与甲状腺疾病的发生、发展的相关性研究奠定了基础,提供了新的研究视角。  相似文献   
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