Marital Quality,Self-compassion and Psychological Distress in Women with Primary Infertility

The current study investigates the relationships among marital quality, self-compassion with psychological distress in women with primary infertility. It was hypothesized that marital quality and self-compassion are likely to predict psychological distress in women with primary infertility. It was further hypothesized that self-compassion is likely to mediate the relationship between marital quality and psychological distress in women with primary infertility. The sample was comprised of 115 women with primary infertility with an age range of 20–35 years (M?=?29.08, SD?=?3.908). The Relationship Assessment Scale (Hendrick in J Marriage Fam, 1988. https://doi.org/10.2307/352430), Self-compassion Scale (Neff in Self Identity 2(3):223–250, 2003. https://doi.org/10.1080/15298860309027), and Depression, Anxiety, Stress Scale (Lovibond and Lovibond in Manual for the depression anxiety stress scales, 2nd edn. Psychology Foundation, 1995) were used to measure the study variables. SPSS was used to analyze the data. Pearson Product Moment Correlation showed that marital quality was positively related to self-compassion and negatively associated with psychological distress (depression, anxiety, and stress). Furthermore, self-compassion was negatively associated with psychological distress (depression, anxiety, and stress). Mediation analysis with the help of Process Macro revealed that marital quality was significantly predicting depression and stress but not anxiety among women with primary infertility, whereas self-compassion was significantly predicting depression, anxiety, and stress among women with primary infertility. Self-compassion was significantly mediating the relationship between marital quality and psychological distress (depression and stress) in women with primary infertility. The study showed that self-compassion could be an important variable for the management of infertility-related issues.

     

Etiology of acute viral respiratory infections common in Pakistan: A review

Respiratory infections, especially those of the lower respiratory tract, remain a foremost cause of mortality and morbidity of children greater than 5 years in developing countries including Pakistan. Ignoring these acute‐level infections may lead to complications. Particularly in Pakistan, respiratory infections account for 20% to 30% of all deaths of children. Even though these infections are common, insufficiency of accessible data hinders development of a comprehensive summary of the problem. The purpose of this study was to determine the prevalence rate in various regions of Pakistan and also to recognize the existing viral strains responsible for viral respiratory infections through published data. Respiratory viruses are detected more frequently among rural dwellers in Pakistan. Lower tract infections are found to be more lethal. The associated pathogens comprise respiratory syncytial virus (RSV), human metapneumovirus (HMPV), coronavirus, enterovirus/rhinovirus, influenza virus, parainfluenza virus, adenovirus, and human bocavirus. RSV is more dominant and can be subtyped as RSV‐A and RSV‐B (BA‐9, BA‐10, and BA‐13). Influenza A (H1N1, H5N1, H3N2, and H1N1pdm09) and Influenza B are common among the Pakistani population. Generally, these strains are detected in a seasonal pattern with a high incidence during spring and winter time. The data presented include pneumonia, bronchiolitis, and influenza. This paper aims to emphasise the need for standard methods to record the incidence and etiology of associated pathogens in order to provide effective treatment against viral infections of the respiratory tract and to reduce death rates.     

Correction to: Overall survival analysis in patients with metastatic breast cancer and liver or lung metastases treated with eribulin,gemcitabine, or capecitabine

Breast Cancer Research and Treatment - In the original publication, two values provided for landmark survival for patients treated with gemcitabine were incorrectly listed in the text. On page 562,...     

Hematopoietic stem cell transplantation in T-prolymphocytic leukemia: a retrospective study from the European Group for Blood and Marrow Transplantation and the Royal Marsden Consortium

T-prolymphocytic leukemia (T-PLL) has a very poor prognosis with conventional immunochemotherapy. Incidental reports suggest that allogeneic hematopoietic stem cell transplantation (allo-HSCT) might have a role in this disease. Therefore, the purpose of the present study was to analyze the outcome of transplants for T-PLL registered with the European Group for Blood and Marrow Transplantation database and the Royal Marsden Consortium. Eligible were 41 patients with a median age of 51 (24-71) years; median time from diagnosis to treatment was 12 months, and in complete remission (CR) (11), partial remission (PR) (12), stable or progressive disease (13) and unknown in 5 patients. A total of 13 patients (31%) received reduced-intensity conditioning. Donors were HLA-identical siblings in 21 patients, matched unrelated donors in 20 patients. With a median follow-up of surviving patients of 36 months, 3-year relapse-free survival (RFS) and OS was 19% (95% CI, 6-31%) and 21% (95% CI, 7-34%), respectively. Multivariate analysis identified TBI and a short interval between diagnosis and HSCT as factors associated with favorable RFS. Three-year non relapse mortality and relapse incidence were each 41% with the majority of relapses occurring within the first year. These data indicate that allo-HSCT may provide effective disease control in selected patients with T-PLL.     

Chronic monitoring of vascular progression after ischemic stroke using multiexposure speckle imaging and two-photon fluorescence microscopy

Monitoring the progression of the vascular structure and cerebral blood flow (CBF) after brain injury is vital to understand the neurovascular recovery process. Multiexposure speckle imaging (MESI) provides a quantitatively accurate technique for chronically measuring the postocclusion CBF perfusion of the infarct and peri-infarct regions in rodent stroke models, while multiphoton microscopy offers direct visualization of the microvascular structure. In this paper, we present imaging outcomes extending 35 days after photo-thrombotic occlusion, tracking the progression of the vasculature throughout this period. We compare MESI flow estimates within the unresolvable parenchyma with subsurface microvascular volume fractions taken with two-photon microscopy in the same regions to assess how the vascular density influences the surface-integrated MESI flow values. The MESI flow measurements and volume fractions are shown to have high correlations (r=0.90) within areas of recovering vasculature in the peri-infarct region. We also observe vascular reorientation occurring within the microvascular structure throughout the 35-day postocclusion period. With the combination of a chronic mouse model and relatively noninvasive optical imaging techniques, we present an imaging protocol for monitoring long-term vascular progression after photo-thrombotic occlusion with the potential to test the efficacy of rehabilitation and pharmacological therapies.