收费全文 | 3716篇 |
免费 | 221篇 |
国内免费 | 25篇 |
耳鼻咽喉 | 36篇 |
儿科学 | 170篇 |
妇产科学 | 58篇 |
基础医学 | 461篇 |
口腔科学 | 290篇 |
临床医学 | 231篇 |
内科学 | 511篇 |
皮肤病学 | 75篇 |
神经病学 | 130篇 |
特种医学 | 160篇 |
外科学 | 696篇 |
综合类 | 104篇 |
一般理论 | 4篇 |
预防医学 | 166篇 |
眼科学 | 89篇 |
药学 | 457篇 |
中国医学 | 33篇 |
肿瘤学 | 291篇 |
2023年 | 28篇 |
2022年 | 28篇 |
2021年 | 108篇 |
2020年 | 80篇 |
2019年 | 96篇 |
2018年 | 135篇 |
2017年 | 98篇 |
2016年 | 115篇 |
2015年 | 126篇 |
2014年 | 154篇 |
2013年 | 220篇 |
2012年 | 308篇 |
2011年 | 305篇 |
2010年 | 159篇 |
2009年 | 158篇 |
2008年 | 172篇 |
2007年 | 184篇 |
2006年 | 140篇 |
2005年 | 92篇 |
2004年 | 105篇 |
2003年 | 72篇 |
2002年 | 69篇 |
2001年 | 67篇 |
2000年 | 52篇 |
1999年 | 46篇 |
1998年 | 40篇 |
1997年 | 40篇 |
1996年 | 52篇 |
1995年 | 35篇 |
1994年 | 19篇 |
1993年 | 28篇 |
1992年 | 50篇 |
1991年 | 41篇 |
1990年 | 35篇 |
1989年 | 62篇 |
1988年 | 33篇 |
1987年 | 49篇 |
1986年 | 34篇 |
1985年 | 30篇 |
1984年 | 31篇 |
1983年 | 28篇 |
1982年 | 14篇 |
1981年 | 20篇 |
1980年 | 20篇 |
1979年 | 18篇 |
1977年 | 20篇 |
1976年 | 19篇 |
1975年 | 19篇 |
1974年 | 24篇 |
1973年 | 13篇 |
Areas covered: There are appreciable numbers of views to pinpoint signaling axis that support metabolic adaptations of cancer cells in response to environmental pressures including nutritional factors and drug treatments. Specifically, nutritional deprivation and autophagy in certain types of cancer are linked to the abilities of cancer cells to use arginine in an auxotrophic or prototrophic manner.
Expert opinion: Hence, this paper highlights the current scope of arginine- and autophagy-centered metabolic adaptations across tumor types and possible avenues to bring tumors towards cytotoxic or cytostatic death. 相似文献
Background
Inflammation and infections have been associated with prostate cancer progression. We assessed whether elevated serum cytokines or T. vaginalis seropositivity at the time of diagnosis was associated with higher grade or lethal prostate cancer.Patients and Methods
Men with localized or metastatic prostate cancer were included in this study. Cytokine serum levels including interleukin (IL)-1α, IL-1β, IL-2, IL-6, IL-8, monocyte chemotactic protein 1 (CCL-2), tumor necrosis factor α, and growth-regulated oncogene α (CXCL-1) using a multiplex enzyme-linked immunosorbent assay and T. vaginalis serology were measured in blood samples at diagnosis.Results
A total of 324 patients were identified at time of localized disease and 118 at time of metastatic disease. Of the 189 patients with localized disease and clinical follow-up data (median, 73 months), 28 developed lethal disease. There was no association between circulating cytokine levels above median concentrations nor T. vaginalis seropositivity and risk of intermediate- to high-risk or lethal prostate cancer.Conclusion
Higher levels of serum cytokine levels and T. vaginalis seropositivity at diagnosis are not associated with high-grade or lethal prostate cancer and do not aid risk stratification of localized prostate cancer. 相似文献Areas covered: This review focuses on updates on solubility enhancement of poorly water-soluble drugs and process analytical tools such as UV/visible spectrophotometry; near-infrared spectroscopy; Raman spectroscopy; and rheometry for continuous manufacturing, with a special emphasis on fused deposition modeling 3D printing.
Expert opinion: The strengths, weakness, opportunities, threats (SWOT) and availability of commercial products confirmed wide HME applicability in pharmaceutical research. Increased interest in continuous manufacturing processes makes HME a promising strategy for this application. However, there is a need for extensive research using process analytical tools to establish HME as a dependable continuous manufacturing process. 相似文献