全文获取类型
收费全文 | 2647篇 |
免费 | 158篇 |
国内免费 | 76篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 182篇 |
妇产科学 | 31篇 |
基础医学 | 323篇 |
口腔科学 | 73篇 |
临床医学 | 275篇 |
内科学 | 551篇 |
皮肤病学 | 233篇 |
神经病学 | 124篇 |
特种医学 | 441篇 |
外科学 | 209篇 |
综合类 | 58篇 |
预防医学 | 134篇 |
眼科学 | 21篇 |
药学 | 93篇 |
2篇 | |
中国医学 | 2篇 |
肿瘤学 | 121篇 |
出版年
2023年 | 9篇 |
2021年 | 21篇 |
2020年 | 23篇 |
2019年 | 25篇 |
2018年 | 42篇 |
2017年 | 35篇 |
2016年 | 37篇 |
2015年 | 47篇 |
2014年 | 61篇 |
2013年 | 83篇 |
2012年 | 73篇 |
2011年 | 105篇 |
2010年 | 122篇 |
2009年 | 112篇 |
2008年 | 85篇 |
2007年 | 124篇 |
2006年 | 76篇 |
2005年 | 79篇 |
2004年 | 47篇 |
2003年 | 45篇 |
2002年 | 60篇 |
2001年 | 70篇 |
2000年 | 42篇 |
1999年 | 44篇 |
1998年 | 129篇 |
1997年 | 156篇 |
1996年 | 135篇 |
1995年 | 112篇 |
1994年 | 116篇 |
1993年 | 100篇 |
1992年 | 41篇 |
1991年 | 46篇 |
1990年 | 45篇 |
1989年 | 57篇 |
1988年 | 54篇 |
1987年 | 49篇 |
1986年 | 59篇 |
1985年 | 48篇 |
1984年 | 27篇 |
1983年 | 20篇 |
1982年 | 28篇 |
1981年 | 31篇 |
1980年 | 28篇 |
1979年 | 8篇 |
1978年 | 10篇 |
1977年 | 19篇 |
1976年 | 27篇 |
1975年 | 18篇 |
1974年 | 8篇 |
1966年 | 6篇 |
排序方式: 共有2881条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
5.
Marked intrafamilial phenotypic heterogeneity in dystrophic epidermolysis bullosa caused by inheritance of a mild dominant glycine substitution and a novel deep intronic recessive COL7A1 mutation 下载免费PDF全文
S. Turczynski M. Titeux N. Pironon H.I. Cohn D.F. Murrell A. Hovnanian 《The British journal of dermatology》2016,174(5):1122-1125
6.
Calculation of cut‐off values based on the Autoimmune Bullous Skin Disorder Intensity Score (ABSIS) and Pemphigus Disease Area Index (PDAI) pemphigus scoring systems for defining moderate,significant and extensive types of pemphigus 下载免费PDF全文
C. Boulard S. Duvert Lehembre C. Picard‐Dahan J.S. Kern G. Zambruno C. Feliciani B. Marinovic P. Vabres L. Borradori C. Prost‐Squarcioni B. Labeille M.A. Richard S. Ingen‐Housz‐Oro E. Houivet V.P. Werth D.F. Murrell M. Hertl J. Benichou P. Joly the International Pemphigus Study Group 《The British journal of dermatology》2016,175(1):142-149
7.
Aetiological factors for oral manifestations of HIV 总被引:2,自引:0,他引:2
GD Palmer PG Robinson SJ Challacombe W Birnbaum D Croser PL Erridge T Hodgson D Lewis A McLaren JM Zakrzewska 《Oral diseases》1996,2(3):193-197
OBJECTIVES: Describe the oral diseases in HIV-infected individuals in London, UK and identify social and medical factors related to the presence of specific oral diseases.
DESIGN: Cross-sectional analytic study.
SETTING: Dental clinics.
SUBJECTS: Consecutive sample of 456 patients with HIV infection.
METHODS: Social and medical history and clinical examinations. Univariate and logistic regression analysis.
OUTCOMES: Presence of HIV-associated oral disease.
RESULTS: 80% of patients with AIDS and 50% of patients with HIV had a specific oral disease. The most common diseases were hairy leukoplakia (30%), erythematous candidiasis (24%), pseudomembranous candidiasis (14%), angular chielitis (6%), necrotising periodontal disease (8%) and non-recurrent ulceration (6%).
CONCLUSIONS: The presence of erythematous candidiasis was not related to advanced HIV disease. Pseudomembranous candidiasis, hairy leukoplakia and mucosal ulceration were significantly associated with advanced HIV disease. Smoking was also identified as a strong aetiological factor in oral diseases. Longitudinal studies are required to further explore the prognostic significance of oral diseases in HIV infection. 相似文献
DESIGN: Cross-sectional analytic study.
SETTING: Dental clinics.
SUBJECTS: Consecutive sample of 456 patients with HIV infection.
METHODS: Social and medical history and clinical examinations. Univariate and logistic regression analysis.
OUTCOMES: Presence of HIV-associated oral disease.
RESULTS: 80% of patients with AIDS and 50% of patients with HIV had a specific oral disease. The most common diseases were hairy leukoplakia (30%), erythematous candidiasis (24%), pseudomembranous candidiasis (14%), angular chielitis (6%), necrotising periodontal disease (8%) and non-recurrent ulceration (6%).
CONCLUSIONS: The presence of erythematous candidiasis was not related to advanced HIV disease. Pseudomembranous candidiasis, hairy leukoplakia and mucosal ulceration were significantly associated with advanced HIV disease. Smoking was also identified as a strong aetiological factor in oral diseases. Longitudinal studies are required to further explore the prognostic significance of oral diseases in HIV infection. 相似文献
8.
Background: The use of ozone therapy in the treatment of dental caries is equivocal. The aim of this study was to use an in vitro model to determine the effects of prior ozone application to dentine on biofilm formation and to measure any associated reduction in bacteria viability. Methods: Twenty dentine discs were bonded to the bases of 5 mL polycarbonate screw top vials. Ten dentine discs were infused with ozone for 40 seconds, 10 samples remained untreated as a control. The vials were filled with nutrient medium, sterilized and placed into the outflow from a continuous chemostat culture of Streptococcus mutans and Lactobacillus acidophilus for four weeks. At the conclusion of the experiment bacterial growth was monitored by taking optical density readings of the growth medium in each vial and the outer surface of the dentine specimens were examined by scanning electron microscopy as shown by SEM analysis. Results: Ozone infusion prevented biofilm formation on all the treated samples while there was substantial biofilm present on the control specimens. While the average optical density of the control specimens was almost twice that of the ozone infused dentine (0.710 for the control with a SD of 0.288 and 0.446 for the ozonated samples with a SD of 0.371), the results were not significant (p > 0.05). Conclusions: This preliminary study has shown that the infusion of ozone into non‐carious dentine prevented biofilm formation in vitro from S. mutans and L. acidophilus over a four‐week period. The possibility exists that ozone treatment may alter the surface wettability of dentine through reaction with organic constituents. 相似文献
9.
GT Terézhalmy AR Biesbrock PA Walters JM Grender RD Bartizek 《International journal of dental hygiene》2008,6(4):321-327
Abstract: Aim: To compare plaque removal efficacy of Oral‐B CrossAction (CA) used for 1 min with an American Dental Association (ADA) manual toothbrush used for 2 or 5 min in an examiner‐blind, three‐treatment, six‐period crossover study. Materials and methods: After refraining from all oral hygiene procedures for 23–25 h, subjects were randomly assigned to one of nine possible six‐period (visit) treatment sequences. Plaque was assessed at baseline (Rustogi Modified Navy Plaque Index). Post‐brushing scores were recorded after brushing with a marketed dentifrice and the assigned toothbrush for the specified duration. The same procedure was followed at each of six subsequent visits. Clinical measurements were carried out by the same examiner. Results: Forty subjects completed the study. All three treatments effectively removed plaque from the whole mouth, along the gingival margin and from approximal surfaces. Whole mouth and gingival margin plaque removal scores with CA for 1 min did not differ significantly from scores with the ADA toothbrush used for 2 min. The ADA brush used for 5 min showed significantly greater whole mouth (P < 0.001) and gingival margin (P < 0.001) plaque reduction than the two other treatments. Approximal plaque removal scores did not differ between the three treatments. Conclusions: Efficient plaque removal can be achieved after 1 min of brushing with CA. The amount of plaque removed did not differ significantly from that achieved with the ADA brush after 2 min of brushing. Greater whole mouth and gingival margin plaque removal scores were seen with the ADA brush after 5 min. 相似文献
10.
JM Palefsky M-E Penaranda LT Pierik LA Lagenaur LA MacPhail D Greenspan JS Greenspan 《Oral diseases》1997,3(Z1):S171-S176
Hairy leukoplakia (HL) is a lesion found on the side of the tongue of immunocompromised individuals, including those with human immunodeficiency virus (HIV) infection. The lesion has unique histopathologic features and is characterised by high-level Epstein-Barr virus (EBV) replication, multiple EBV strains, and extensive inter-and intra-strain recombination. Expression of EBV genes spanning the entire viral life cycle from latency-associated genes to late, replicative genes has been detected in the lesion. HL thus provides a unique opportunity to study EBV expression in oral epithelium, and to study expression of novel EBV genes. We therefore constructed a cDNA library from an HL biopsy and detected expression of two genes not previously described in vivo: BMRF-2 and BDLF-3. Sequence analysis of the cDNAs revealed few amino acid changes from the B95-8 sequence. Expression of both genes was localized to the lower prickle cell layer of the tongue epithelium. BMRF-2 protein expression was primarily detected in the cell nuclei of the upper prickle cell layer. BDLF-3 protein expression was observed in the perinuclear space and Golgi compartment. The function of these proteins is currently under investigation. 相似文献