全文获取类型
收费全文 | 9431篇 |
免费 | 586篇 |
国内免费 | 80篇 |
专业分类
耳鼻咽喉 | 156篇 |
儿科学 | 107篇 |
妇产科学 | 116篇 |
基础医学 | 1451篇 |
口腔科学 | 218篇 |
临床医学 | 662篇 |
内科学 | 1851篇 |
皮肤病学 | 352篇 |
神经病学 | 601篇 |
特种医学 | 497篇 |
外科学 | 1465篇 |
综合类 | 34篇 |
一般理论 | 3篇 |
预防医学 | 361篇 |
眼科学 | 201篇 |
药学 | 842篇 |
中国医学 | 139篇 |
肿瘤学 | 1041篇 |
出版年
2023年 | 54篇 |
2022年 | 35篇 |
2021年 | 310篇 |
2020年 | 149篇 |
2019年 | 262篇 |
2018年 | 299篇 |
2017年 | 232篇 |
2016年 | 374篇 |
2015年 | 462篇 |
2014年 | 541篇 |
2013年 | 558篇 |
2012年 | 889篇 |
2011年 | 795篇 |
2010年 | 478篇 |
2009年 | 388篇 |
2008年 | 576篇 |
2007年 | 521篇 |
2006年 | 473篇 |
2005年 | 462篇 |
2004年 | 379篇 |
2003年 | 323篇 |
2002年 | 248篇 |
2001年 | 254篇 |
2000年 | 214篇 |
1999年 | 151篇 |
1998年 | 62篇 |
1997年 | 49篇 |
1996年 | 36篇 |
1995年 | 50篇 |
1994年 | 37篇 |
1993年 | 31篇 |
1992年 | 72篇 |
1991年 | 52篇 |
1990年 | 40篇 |
1989年 | 36篇 |
1988年 | 37篇 |
1987年 | 31篇 |
1986年 | 25篇 |
1985年 | 23篇 |
1984年 | 9篇 |
1983年 | 9篇 |
1981年 | 6篇 |
1980年 | 6篇 |
1979年 | 8篇 |
1978年 | 5篇 |
1977年 | 4篇 |
1976年 | 7篇 |
1974年 | 4篇 |
1973年 | 6篇 |
1968年 | 6篇 |
排序方式: 共有10000条查询结果,搜索用时 62 毫秒
1.
2.
3.
Youjin Kim Chu Hyun Kim Ho Yun Lee Se-Hoon Lee Hong Sook Kim Sook Lee Hongui Cha Sungjun Hong Kyunga Kim Sang Won Seo Jong-Mu Sun Myung-Ju Ahn Jin Seok Ahn Keunchil Park 《Journal of thoracic oncology》2019,14(9):1608-1618
IntroductionHyperprogressive disease (HPD), characterized by accelerated tumor progression, has been proposed as a new pattern of progression after immune checkpoint inhibitor (ICI) treatment. The aim of this study was to describe the characteristics of HPD and investigate its predictive markers.MethodsClinical and radiological findings of 335 patients with advanced NSCLC treated with ICI monotherapy were retrospectively analyzed. Radiological data were quantitatively and longitudinally analyzed for tumor size and volume by comparing baseline and follow-up computerized tomography results. The findings were matched with individual genomic profiles generated by deep sequencing of 380 genes.ResultsAmong 135 patients with progressive disease (PD), as assessed by the Response Evaluation Criteria in Solid Tumors version 1.1 criteria, 48 (14.3% of all patients and 35.6% of those with PD) and 44 (13.1% of all patients and 32.6% among those with PD) were found to have HPD by volumetry (HPDV) and assessed by RECIST 1.1 (HPDR), respectively. Patients with HPDV were associated with significantly inferior overall survival (OS) versus that of patients without HPDV with PD (median OS = 4.7 months [95% confidence interval: 3.5–11.9)] versus 7.9 months [95% confidence interval: 6.0–13.5] [p = 0.004]); OS did not differ between patients without and without HPDR. HPDV status was an independent factor in OS. A derived neutrophil-to-lymphocyte ratio greater than 4 and lactate dehydrogenase level greater than the upper limit of normal were significantly associated with HPDV. Moreover, we identified coinciding KRAS and serine/threonine kinase 11 gene (STK11) mutations in the cohort of patients with HPDV (three of 16), whereas none were found in the cohort of patients without HPDV (zero of 28).ConclusionsDefining HPD treated with ICI on the basis of volumetric measurement is more precise than is defining it on the basis of one-dimensional analysis. Pre-ICI derived neutrophil-to-lymphocyte ratio, lactate dehydrogenase level, and concurrence of STK11 and KRAS mutations could thus be used as potential biomarkers for HPD prediction. 相似文献
4.
5.
Fordyce spots are ectopic sebaceous glands which typically present as asymptomatic, multiple whitish, or yellowish 1–3‐mm sized papules on the lips. Several therapeutic approaches have been proposed such as laser, electrical or chemical ablation, and micropunch excision. However, these modalities pose the risk of scarring from inevitable surface damage. In this report, we present a case of Fordyce spots which was successfully treated with intralesional electrocoagulation using a proximally insulated microneedle and monopolar radiofrequency device, resulting in marked cosmetic improvements without surface damage. 相似文献
6.
Deok‐Bog Moon Sung‐Gyu Lee Shin Hwang Chul‐Soo Ahn Ki‐Hun Kim Tae‐Yong Ha Gi‐Won Song Dong‐Hwan Jung Gil‐Chun Park Young‐In Yoon Hwui‐Dong Cho Jae‐Hyun Kwon Yong‐Kyu Jung Su‐Min Ha 《Transplant international》2019,32(5):535-545
Simultaneous splenectomy (SSPX) in adult living donor liver transplantation (ALDLT) has definitely beneficial roles such as portal flow modulation in small‐for‐size graft and correction of hypersplenism‐related pancytopenia, and so on, but disastrous complications after SSPX often occur. For the first time, we devised unique and innovative splenic devascularization (SDV) procedure to alleviated untoward effects of SSPX but to maintain its benefits for the indicated patients. From April 2013 to December 2014, 520 recipients underwent ALDLT, and the SSPX and SDV were simultaneously performed in 62 (11.9%) and 61 (11.7%) patients, respectively. The most common indication was hypersplenism‐related pancytopenia (n = 101), small‐for‐size graft (n = 14), hepatitis C virus (HCV) (n = 7), and splenic artery aneurysm (n = 1). Postoperative small‐for‐size graft syndrome (SFSS) was absent in both SSPX and SDV, and preoperative pancytopenia was improved in both groups since postoperative 1 week, although SSPX was more substantial than SDV. Preoperative splenic volume (706.2 ± 282.9 ml) after SDV significantly decreased to 425.5 ± 204.4 ml on 1 month, respectively. In contrast to SDV, SSPX resulted in longer operation time and higher incidence of postoperative complications including mortality. In conclusion, SDV can replace SSPX during ALDLT without hampering its beneficial roles seriously, but get rid of splenectomy‐related lethal complication. 相似文献
7.
BackgroundIn planning a skin graft, the texture, color, and size of the recipient and donor site tissues should be considered.ObjectiveWe determined the optimal donor sites for nasal full-thickness skin grafting based on biophysical parameters.MethodsThirty women over the age of 60 were selected for this study. Four recipient sites (nasal root, dorsum, tip, ala) and three donor sites (preauricle, postauricle, forehead) were considered. Biophysical parameters such as transepidermal water loss (TEWL), capacitance, sebum output, erythema/melanin value, and skin replica technique were tested.ResultsThe nasal root was correlated with the forehead in terms of TEWL and sebum output. The nasal dorsum was correlated with the preauricle in terms of TEWL, erythema/melanin value, and skin replica measurements. The nasal tip was correlated with the preauricle in terms of TEWL, sebum output, erythema/melanin value, and skin replica measurements. The ala was correlated with the forehead in terms of TEWL and skin replica measurements.ConclusionThe preauricule is the optimal donor site for resurfacing of the nasal dorsum and tip. The forehead is a good donor site for alar defects. For resurfacing of the nasal root, the forehead and postauricle are good choices. 相似文献
8.
9.
Nephrotoxicity is a major concern for patients with psoriasis using cyclosporine. Here, we evaluated the impact of intermittent cyclosporine treatment on nephrotoxicity risk among patients with psoriasis in real‐world clinical practice. We retrospectively reviewed 611 patients with psoriasis treated with cyclosporine between January 2013 and January 2017, 398 of whom were considered eligible for analysis. Eighteen (4.5%) patients showed a greater than 25% increase in serum creatinine levels. Age over 60 years (relative risk [RR], 1.6; p = .015), diabetes (RR, 2.3; p < .001), and obesity (RR, 1.7; p = .011) were the significant risk factors of increased serum creatinine levels in patients with psoriasis. There was no significant association of the treatment duration or cumulative dose of cyclosporine with increased serum creatinine levels. In real clinical practice, intermittent cyclosporine use with regular serum creatinine tests can be used to treat psoriasis relatively safely. Age over 60 years, diabetes and obesity are significant risk factors for cyclosporine‐induced nephrotoxicity. 相似文献