全文获取类型
收费全文 | 3734篇 |
免费 | 251篇 |
国内免费 | 16篇 |
专业分类
耳鼻咽喉 | 39篇 |
儿科学 | 124篇 |
妇产科学 | 42篇 |
基础医学 | 491篇 |
口腔科学 | 423篇 |
临床医学 | 308篇 |
内科学 | 737篇 |
皮肤病学 | 143篇 |
神经病学 | 165篇 |
特种医学 | 294篇 |
外科学 | 443篇 |
综合类 | 62篇 |
一般理论 | 1篇 |
预防医学 | 319篇 |
眼科学 | 76篇 |
药学 | 157篇 |
中国医学 | 20篇 |
肿瘤学 | 157篇 |
出版年
2023年 | 25篇 |
2022年 | 26篇 |
2021年 | 85篇 |
2020年 | 82篇 |
2019年 | 95篇 |
2018年 | 128篇 |
2017年 | 89篇 |
2016年 | 77篇 |
2015年 | 106篇 |
2014年 | 170篇 |
2013年 | 224篇 |
2012年 | 297篇 |
2011年 | 252篇 |
2010年 | 176篇 |
2009年 | 189篇 |
2008年 | 198篇 |
2007年 | 228篇 |
2006年 | 174篇 |
2005年 | 143篇 |
2004年 | 114篇 |
2003年 | 90篇 |
2002年 | 83篇 |
2001年 | 62篇 |
2000年 | 55篇 |
1999年 | 49篇 |
1998年 | 89篇 |
1997年 | 55篇 |
1996年 | 71篇 |
1995年 | 52篇 |
1994年 | 54篇 |
1993年 | 52篇 |
1992年 | 30篇 |
1991年 | 20篇 |
1990年 | 19篇 |
1989年 | 45篇 |
1988年 | 36篇 |
1987年 | 30篇 |
1986年 | 30篇 |
1985年 | 19篇 |
1984年 | 18篇 |
1983年 | 19篇 |
1982年 | 15篇 |
1981年 | 22篇 |
1980年 | 14篇 |
1979年 | 11篇 |
1978年 | 11篇 |
1977年 | 19篇 |
1976年 | 11篇 |
1975年 | 11篇 |
1969年 | 9篇 |
排序方式: 共有4001条查询结果,搜索用时 15 毫秒
1.
Maria Carolyna Fonseca Batista Arbex Jane Erika Frazão Okazaki Daniela Regina Brandão Tavares Ana Laura Figueiredo Bersani Fania Cristina Santos 《Journal of orthopaedic science》2021,26(1):162-166
BackgroundIn 2007, the Japanese Orthopedic Association established the term “Locomotive Syndrome” (LS) for the concept of locomotor organ dysfunction with potential loss of independence. The purpose of this study was to identify characteristics of LS and establish a diagnostic cut-off for the Geriatric Locomotive Function Scale (GLFS 25-p) for the Brazilian population.MethodsA cross-sectional observational study of the LOCOMOV Project cohort of independent outpatients aged ≥80 years was conducted. Questionnaires on functional status in Basic and Instrumental Activities of Daily Living (Katz and Lawton, respectively) and quality of life (WHOQOL-Bref) were applied, together with the Geriatric Locomotive Function Scale (GLFS 25-p) to identify individuals with LS. Mobility was assessed using the five-times sit-to-stand test, 4-m gait speed, two-step test, one-leg standing time with eyes open and hand-grip test. The data were analyzed using Student's t-test, the Chi–Square test, and multiple logistic regression (stepwise). The significance level was set at 0.05 (5%).ResultsA sample of 102 individuals with mean age of 87.3 (±4.2) years and predominantly female (73.5%) was assessed. We determined a cut-off score of 19 (sensitivity of 0.86 and specificity of 0.67) for diagnosis of LS, as assessed by the GLFS 25-p, and a high prevalence (55%) of the syndrome was found in the sample. In the multiple regression analysis, LS was directly associated with chronic pain (OR 22.24, 95%CI 3.13–157.87), use of a walking device (OR 17.121, 95%CI 1.94–150.49), and inversely associated with gait speed ≥0.8 m/s (OR 0.42, 95%CI 0.006–0.278), perception of good health (OR 0.153, 95%CI 0.029–0.799) and male gender (OR 0.086, 95%CI 0.0105–0.714).ConclusionThe LS in the oldest old proved a very common condition in this survey, especially in women, and was strongly associated with chronic pain, worse performance on physical tests and poor quality of life. 相似文献
2.
Gutierre Marcela Usberti Telles João Paulo Mota Welling Leonardo Christiaan Rabelo Nícollas Nunes Teixeira Manoel Jacobsen Figueiredo Eberval Gadelha 《Neurosurgical review》2021,44(4):2091-2097
Neurosurgical Review - Cellular response to TBI is a mixture of excitotoxicity, neuroinflammation, and cell death. Biomarkers that can track these lesions and inflammatory processes are being... 相似文献
3.
Traboulsi-Garet Bassel Jorba-García Adrià Camps-Font Octavi Alves Fabio Abreu Figueiredo Rui Valmaseda-Castellón Eduard 《Clinical oral investigations》2022,26(3):2371-2382
Clinical Oral Investigations - To determine the usefulness of Serum C-terminal telopeptide cross-link of type 1 collagen (sCTX) as a preoperative marker for predicting the risk of developing... 相似文献
4.
Miriam S. Menezes Maria das Graças Mota da Cruz de Assis Figueiredo 《Brazilian Journal of Anesthesiology》2019,69(1):72-77
Background and objective
Palliative sedation is a medical procedure that has been used for more than 25 years to relieve refractory symptoms not responsive to any previous treatment in patients with no possibility of cure and near the end of life. Many uncertainties persist on the theme regarding definition, indications, decision making, most appropriate place to perform the procedure, most used drugs, need for monitoring, fluids and nutritional support, and possible ethical dilemmas. The objective of this review was to seek a probable consensus among the authors regarding these topics not yet fully defined.Method
An exploratory search was made in secondary sources, from 1990 to 2016, regarding palliative sedation and its clinical and bioethical implications.Conclusions
Palliative sedation is an alternative to alleviate end‐of‐life patient suffering due to refractory symptoms, particularly dyspnea and delirium, after all other treatment options have been exhausted. Decision making involves prior explanations, discussions and agreement of the team, patient, and/or family members. It can be performed in general hospital units, hospices and even at home. Midazolam is the most indicated drug, and neuroleptics may also be required in the presence of delirium. These patients’ monitoring is limited to comfort observation, relief of symptoms, and presence of adverse effects. There is no consensus on whether or not to suspend fluid and nutritional support, and the decision must be made with family members. From the bioethical standpoint, the great majority of authors are based on intention and proportionality to distinguish between palliative sedation, euthanasia, or assisted suicide. 相似文献5.
Amanda Leal Rocha Alessandra Figueiredo De Souza Laiz Fernandes Mendes Nunes Nayara Dias de Souza Cunha Clia Regina Moreira Lanza Denise Vieira Travassos Tarcília Aparecida da Silva 《Pediatric dermatology》2019,36(1):e27-e30
Drug‐induced reactions are complications associated with high mortality and significant morbidity. Stevens–Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) are examples of these conditions, which are characterized by skin and mucous lesions. Here, we report a case of a 9‐year‐old girl who presented with blisters associated with an extensive vesicular rash and multiple ulcerations on the lips and oral cavity. A drug‐induced hypersensitivity reaction to antibiotics was suspected, and a diagnosis of TEN was made. The patient was managed with withdrawal of the suspected causative agent, and the oral lesions were treated with low‐level laser therapy (LLLT) and oral hygiene. This case highlights that TEN requires interdisciplinary intervention with dental assistance and follow‐up to improve symptoms, nutrition, systemic condition, and quality of life. 相似文献
6.
Samir Gupta MD MDCS AGAF Balambal Bharti MBBS MPH PhD Dennis J. Ahnen MD Daniel D. Buchanan PhD Iona C. Cheng PhD MPH Michelle Cotterchio PhD Jane C. Figueiredo PhD Steven J. Gallinger MD MSc Robert W. Haile DrPH MPH Mark A. Jenkins PhD Noralane M. Lindor MD Finlay A. Macrae MD AGAF Loïc Le Marchand MD PhD Polly A. Newcomb PhD MPH Stephen N. Thibodeau PhD Aung Ko Win MBBS MPH PhD Maria Elena Martinez PhD 《Cancer》2020,126(13):3013-3020
7.
8.
9.
10.
R.D. Olmos R.C. de Figueiredo E.M. Aquino P.A. Lotufo I.M. Bensenor 《Brazilian journal of medical and biological research》2015,48(8):751-758
Thyroid diseases are common, and use of levothyroxine is increasing worldwide. We
investigated the influence of gender, race and socioeconomic status on the diagnosis
and treatment of thyroid disorders using data from the Brazilian Longitudinal Study
of Adult Health (ELSA-Brasil), a multicenter cohort study of civil servants (35-74
years of age) from six Brazilian cities. Diagnosis of thyroid dysfunction was by
thyrotropin (TSH), and free thyroxine (FT4) if TSH was altered, and the use of
specific medications. Multivariate logistic regression models were constructed using
overt hyperthyroidism/hypothyroidism and levothyroxine use as dependent variables and
sociodemographic characteristics as independent variables. The frequencies of overt
hyper- and hypothyroidism were 0.7 and 7.4%, respectively. Using whites as the
reference ethnicity, brown, and black race were protective for overt hypothyroidism
(OR=0.76, 95%CI=0.64-0.89, and OR=0.53, 95%CI=0.43-0.67, respectively, and black race
was associated with overt hyperthyroidism (OR=1.82, 95%CI=1.06-3.11). Frequency of
hypothyroidism treatment was higher in women, browns, highly educated participants
and those with high net family incomes. After multivariate adjustment, levothyroxine
use was associated with female gender (OR=6.06, 95%CI=3.19-11.49) and high net family
income (OR=3.23, 95%CI=1.02-10.23). Frequency of hyperthyroidism treatment was higher
in older than in younger individuals. Sociodemographic factors strongly influenced
the diagnosis and treatment of thyroid disorders, including the use of
levothyroxine. 相似文献