5-HT6受体拮抗剂参与学习记忆过程的机制

大量的研究表明5-羟色胺(5-HT)通过与多种受体相结合及与多种神经递质系统相互作用从而在学习记忆中发挥重要的作用。5-HT受体根据其结构、分布和功能分为7个家族、14种亚型,其中参与学习记忆过程的受体亚型主要有:5-HT1A、5-     

早期帕金森病患者事件相关电位P300研究

目的研究早期帕金森病（PD）患者听觉事件相关电位P300的异常特征，为早期干预PD患者认知功能损害提供实验依据。方法早期PD患者83例（PD组），健康人58例（对照组）。肌电图诱发电位仪测定两组P300波群各成分（N1、P2、N2、P3）潜伏期和波幅、反应时，MMSE评定两组的认知功能。结果PD组N2、P3潜伏期延长（P〈0．05）；P300波群各成分中P3阳性率最高[PD痴呆组为53．3％，PD非痴呆（PD—D）组为29．4％]。结论早期PD患者P300外源性成分P2和内源性成分N2、P3的潜伏期均延长，提示其认知功能异常，还有警觉、选择、注意的障碍。P3潜伏期是识别早期PD伴发痴呆的敏感指标。     

全面性发作癫(癎)患者记忆功能与海马质子磁共振波谱改变的相关性分析

目的 探讨原发性癫(癎)全面性发作患者记忆功能损害的特征以及磁共振波谱(magnetic resonance spectroscopy,MRS)检查与记忆功能的关系.方法 对45例癫(癎)全面性发作的患者和20例健康对照组进行临床记忆量表的测量,双侧海马行1H-MRS检测及体积测量,比较2组间记忆量表的各项量表分、记忆商和1H-MRS的各项指标,并对记忆量表的结果与海马1H-MRS结果进行相关分析.结果 癫(癎)组包括服药组(指向记忆15.68±4.79,联想学习18.70±5.84,图像自由回忆13.19±6.22,人像特点回忆12.02±4.31)与未服药组(指向记忆17.19±5.86,联想学习20.00±6.77,图像自由回忆18.44±6.62,人像特点回忆13.19±6.62)以及不同发作频率组的多数项量表分及记忆商(服药组74.64 ±18.52,未服药组79.07±20.20,≥3次/月组78.10±21.22,<3次/月组73.81±17.72)显著低于对照组(t=4.794-10.224,P<0.01);且癫(癎)服药组和发作频率≥3次/月组的各项量表分及记忆商显著低于服药组和发作频率<3次/月组(t=3.267～6.537,P<0.01).癫(癎)组海马体积(左侧2.45±0.25,右侧2.56±0.31)、N-乙酰天门冬氨酸(NAA,左侧12.93±1.73,右侧11.88±1.69)及NAA/胆碱(Cho)+肌酸(Cr,左侧0.48±0.08,右侧0.39±0.07)显著低于对照组,Cho(左侧15.02±0.86,右侧14.94±0.96)、Cr(左侧11.86±0.71,右侧10.71±0.42)显著高于对照组(t=4.103～5.768,P<0.01);癫(癎)组的各项量表分及记忆商与左右侧NAA浓度、NAA/Cho+Cr均呈明显正相关(r=O.489～0.727,P相似文献   

体感诱发电位的高频振荡成分在皮层下动脉硬化性白质病变的观察

目的探讨体感诱发电位(SEPs)高频振荡(HFQs)成分在皮层下动脉硬化性白质病变的异常表现，及其HT能的病理生理基础。方法在一组诊断明确的皮层下动脉硬化性白质病变的病人共70例中，进行正中神经体感诱发电位和高频振荡成分的检测，比较常规体感诱发电位成分和高频振荡成分的异常率和异常模式。结果常规体感诱发电位成分的异常率为8．6％，HFOs的异常率为45．7％；两者的异常模式有：两者同时异常4．3％，常规体感诱发电位成分正常，HFOs异常41．4％，常规体感诱发电位成分异常，HFOs正常4．3％。结论体感诱发电位高频成分和常规成分的异常反映感觉传入过程中不同的紊乱模式，高频成分对皮层下的神经纤维轻度脱髓鞘更为敏感，对常规体感诱发电位是一个有益的扩充指标。     

动态脑电图分级对昏迷患者预后的评估价值

目的观察动态脑电图检测对昏迷患者预后的评估价值。方法在98例不同病因昏迷患者急性期进行动态脑电图检测和格拉斯哥昏迷评分(GCS),随访患者3个月的预后,将动态脑电图检测和GCS评分结果与患者的预后结果进行相关分析。结果脑电图异常分级与GCS评分显负相关(r=0.751,P<0.001),脑电图分级为Ⅰ级:GCS为7.0±0.7,Ⅱ级时GCS为7.3±1.2,Ⅲ级时GCS为4.0±0.0,Ⅴ级时GCS为3.2±0.4;动态脑电图异常分级在死亡或植物状态组和残疾生存组与康复组比较差异均有统计学意义,GCS评分在死亡或植物状态组与康复组比较差异有统计学意义,而残疾生存组与康复组比较差异没有统计学意义。动态脑电图对植物状态和残疾生存患者预后的评估在敏感性(81.25%)、特异性(100%)和对预后评估的准确率(91.89%)方面均比GCS评分高。结论急性期动态脑电图检测对植物状态和残疾生存患者预后的评估有确切肯定的价值。     

二例先天性肌强直的CLCNl基因突变研究

目的 探讨2例先天性肌强直患者的氯离子通道蛋白-1(chloride channcl 2,CLCN1)基因突变情况和临床特点.方法 收集福建地区1个先天性肌强直家系的先证者和1例散发性先天性肌强直患者的临床资料并进行综合分析.用PCR扩增患者CLCN1基因的全部外显子,通过直接测序检测突变的情况.结果 家系1先证者的CLCN1基因第8外显子存在c.1024 G>A的杂合性错义突变,散发性患者的CLCN1基因第11外显子发现了c.1292 C>T的杂合性错义突变.结论 先天性肌强直症临床表现缺乏特异性,CLCN1基因突变检测是确诊该病的有效方法.     

正中神经体感诱发电位在帕金森病中的诊断价值

正中神经体感诱发电位(SLSEP)顶部记录为N_(20)-P_(25)复合波,中央前记录为P_(22)-N_(30)复合波。已有的研究表明,中央前成份由运动区起源,并同运动及运动机制有关。帕金森病是由黑质-纹状体病变引起的锥体外系综合征。对该病的体感诱发电位研究国内仍未见类似报道。本文拟研究早期帕金森病的SLSEP顶、中央前成份的异常特征、病理机制及可能的诊断。     

抑郁、焦虑对癫(癎)患者健康相关生存质量的影响

Objective To assess health-related quality of life and the mood disorder in adults with epilepsy,and to evaluate factors contributing to the quality of life.Methods Quality of life was measured by the Quality of Life in Epilepsy Inventory(QOLIE-31)and the World Health Organization Quality of Life Assessment-Bref(WHOQOL-BREF).Psychotic conditions were evaluated by Self-rating Depressive Scale (SDS)and Self-rating Anxious Seale(SAS).The multivariate analysis was used to assess the determinant factors.Results The study included 141 epilepsy patients in the teat group and 59 sex,age,and education matched normal controls. WHOQOL-BREF scores in the physical and psychological aspects were significantly lower in epilepsy patients(12.7 ±1.8 and 12.4±1.9,respectively)than those in the normal controls(15.1 ±2.3 and 13.9 ±1.9,respectively,t value were 11.75 and 8.625.both P<0.05).The survey reported that 57.4 % of the epilepsy patients suffered with depression.and 39.7 % anxiety.The patients with both anxiety and depression scored lower in all aspects in QOLIE survey except medical effect.Multivariate analysis showed that factors that effect the overall quality of life in order were anxiety.depression and disease duration.Conclusion Our results support that complications of anxiety and depression and long disease duration are key factors affecting the quality of life in epilepsy patients.     

抑郁、焦虑对癫(癎)患者健康相关生存质量的影响

Objective To assess health-related quality of life and the mood disorder in adults with epilepsy,and to evaluate factors contributing to the quality of life.Methods Quality of life was measured by the Quality of Life in Epilepsy Inventory(QOLIE-31)and the World Health Organization Quality of Life Assessment-Bref(WHOQOL-BREF).Psychotic conditions were evaluated by Self-rating Depressive Scale (SDS)and Self-rating Anxious Seale(SAS).The multivariate analysis was used to assess the determinant factors.Results The study included 141 epilepsy patients in the teat group and 59 sex,age,and education matched normal controls. WHOQOL-BREF scores in the physical and psychological aspects were significantly lower in epilepsy patients(12.7 ±1.8 and 12.4±1.9,respectively)than those in the normal controls(15.1 ±2.3 and 13.9 ±1.9,respectively,t value were 11.75 and 8.625.both P<0.05).The survey reported that 57.4 % of the epilepsy patients suffered with depression.and 39.7 % anxiety.The patients with both anxiety and depression scored lower in all aspects in QOLIE survey except medical effect.Multivariate analysis showed that factors that effect the overall quality of life in order were anxiety.depression and disease duration.Conclusion Our results support that complications of anxiety and depression and long disease duration are key factors affecting the quality of life in epilepsy patients.