益气、活血方药对冠心病临床疗效观察

本文对35例冠心病住院患者,先后交替静脉点滴益气液(26例次)、活血液(35例次)及益气液与活血液同用(19例次),各用药2周。采用单盲、自身先后对照的方法观察了对冠心病心绞痛的近期临床疗效。结果是心绞痛症状及心电图的总有效率分别为:益气组76.19%、19.24%;活血组85.71%、60%;益气活血组76%、43.26%。三组间心绞痛症状的总有效率无明显差异;心电图的总有效率益气组低于活血组及益气活血组。     

生脉散对冠心病心绞痛患者左心室功能的影响

冠心病心绞痛患者多有心气虚的临床表现,尤其是急性心肌梗塞患者伴有心衰或休克时,心气虚等表现更为明显。生脉散治疗冠心病已获得较好的疗效,为探讨心气虚的实质以及生脉散的作用机理,我们应用心脏收缩时相(Systolic Time Intervals简称STI)及心尖搏动图为观察方法,选择一组冠心病心绞痛具有心气虚表现的患者,观察生脉散注射液对左心室功能的影响。     

生脉液对冠心病患者血浆cAMP含量的影响及其与左心功能改善的关系

临床研究表明生脉液能提高冠心病心绞痛、急性心肌梗塞病人心脏的射血分数,改善左室功能。生脉液对冠心病患者血浆cAMP含量的影响及其与左心功能改善的关系尚未见报道。本文对此进行了初步观察,现将结果报告如下。     

生脉液对急性心肌梗塞患者左心室功能的影响

生脉液已广泛用于治疗急性心肌梗塞伴休克、心衰的患者,并取得了较好的临床疗效。为了进一步了解生脉液对急性心肌梗塞左心功能的效应,并初步探索其作用原理,本文应用心脏收缩时相(SystolicTime Intervals;以下简称 STI)和心尖搏动图观察了生脉液对急性心肌梗塞患者左心室功能的影响,报告如下:     

EFFECT OF SHENG MAI SAN ON LEFT VENTRICULAR PERFORMANCE IN CORONARY HEART DISEASE

The present study aims at ascertaining thenature of Xin Qi Xu (XQX,deficiency of Heart-Qi) and the effect of the drug Sheng Mai San 生脉散(SMS) on heart performance,using systolicand diastolic time intervals as criteria in CHDassociated with XQX patients.The results ascompared with normal subjects showed increa-ses in QA_2,PEP,ICT,IRP,SFP,RFP,a/H%,PEP/LVET and SFP/RFP and a reduction ofLVET,suggesting that the patients have a la-tent cardiac insufficiency possibly relating tothe nature of XQX.The changes in systolic anddiastolic time intervals after intravenous ShengMai San were prolongation of MST and LVET,shortening of PEP and PEP/LVET,and slowingof heart rate.These changes are statisticallysignificant (P<0.05-0.001).The blood pressurewas not significantly changed.These changesand their degree suggest a positive inotropic ac-tion on myocardium and a reduction of myo-cardial oxygen consumption by Sheng Mat San.Its effects compared with Cedilanid-D showedthat the action of both drugs on systolic anddiastolic time intervals was similar.We ten-tatively suggest,therefore,that the inotropicaction of SMS simulates that of digitalis glycosi-des.Further studies are needed to determinewhether SMS affects the heart in the same wayas digitalis glycosides,for current work indica-tes that SMS may have other effects on theheart.