郭氏马钱汤对中度氟骨症肘、膝关节屈伸运动的影响

目的 观察治疗前后中度氟骨症患者的肘、膝关节屈伸活动度数,评价郭氏马钱汤对中度氟骨症患者肘、膝关节届伸功能的改善作用.方法 将54例中度氟骨症患者随机分为两组,治疗组采用郭氏马钱汤治疗,8周后改服骨康宁胶囊;对照组采用空白安慰剂,8周后改服骨康宁胶囊安慰剂.结果 治疗结束时两组肘关节的屈伸功能改善明显,治疗组优于对照组(P<0.05),而膝关节的屈伸功能改善差异无统计学意义;24周随访时肘、膝关节的屈伸功能均明显改善,治疗组较对照组差异有统计学意义(P<0.05).结论 郭氏马钱汤可改善中度氟骨症患者的肘、膝关节属伸功能.     

中药改善地方性氟骨症患者症状和能力的临床观察

目的 观察中药改善地方性氟骨症患者症状和能力的疗效.方法 对根据地方性氟中毒诊断标准确诊的30例氟骨症患者,给予以马钱子为主要成分的中药口服治疗,疗程为3个月.观察治疗前后患者自身症状和能力的改善情况.结果 30例中显效21例,有效9例,总有效率100%.结论 以马钱子为主的中药治疗地方性氟骨症疗效确切.     

郭氏马钱汤对中度氟骨症肘、膝关节屈伸运动的影响

目的 观察治疗前后中度氟骨症患者的肘、膝关节屈伸活动度数,评价郭氏马钱汤对中度氟骨症患者肘、膝关节届伸功能的改善作用.方法 将54例中度氟骨症患者随机分为两组,治疗组采用郭氏马钱汤治疗,8周后改服骨康宁胶囊;对照组采用空白安慰剂,8周后改服骨康宁胶囊安慰剂.结果 治疗结束时两组肘关节的屈伸功能改善明显,治疗组优于对照组(P<0.05),而膝关节的屈伸功能改善差异无统计学意义;24周随访时肘、膝关节的屈伸功能均明显改善,治疗组较对照组差异有统计学意义(P<0.05).结论 郭氏马钱汤可改善中度氟骨症患者的肘、膝关节属伸功能.     

中药改善地方性氟骨症患者症状和能力的临床观察

目的观察中药改善地方性氟骨症患者症状和能力的疗效。方法对根据地方性氟中毒诊断标准确诊的30例氟骨症患者，给予以马钱子为主要成分的中药12服治疗，疗程为3个月。观察治疗前后患者自身症状和能力的改善情况。结果30例中显效21例，有效9例，总有效率100％。结论以马钱子为主的中药治疗地方性氟骨症疗效确切。     

郭氏马钱汤对中度氟骨症肘、膝关节屈伸运动的影响

目的 观察治疗前后中度氟骨症患者的肘、膝关节屈伸活动度数,评价郭氏马钱汤对中度氟骨症患者肘、膝关节届伸功能的改善作用.方法 将54例中度氟骨症患者随机分为两组,治疗组采用郭氏马钱汤治疗,8周后改服骨康宁胶囊;对照组采用空白安慰剂,8周后改服骨康宁胶囊安慰剂.结果 治疗结束时两组肘关节的屈伸功能改善明显,治疗组优于对照组(P<0.05),而膝关节的屈伸功能改善差异无统计学意义;24周随访时肘、膝关节的屈伸功能均明显改善,治疗组较对照组差异有统计学意义(P<0.05).结论 郭氏马钱汤可改善中度氟骨症患者的肘、膝关节属伸功能.     

郭氏疗法对中度氟骨症患者临床症状的影响

目的观察郭氏疗法治疗中度氟骨症患者的临床疗效。方法 120例中度氟骨症患者按随机对照原则分为治疗组和对照组各60例,治疗组给予基础治疗和郭氏疗法(主要成分中药马钱子)治疗,对照组给予基础治疗和安慰剂治疗,两组疗程均为12周,并随访24周。分别于治疗前及治疗后第1、2、3、4、8、12、24、36周由第三方进行疼痛视觉模拟评分(VAS)及晨僵、麻木、紧束感、抽搐指标评估。结果两组患者治疗2周后VAS评分较治疗前有明显下降(P0.01);治疗4周后两组差异有统计学意义(P0.01)。治疗2周后患者紧束感症状消失率治疗组高于对照组(P0.05);治疗8周后患者晨僵消失率、抽搐症状消失率治疗组均高于对照组(P0.05);两组间麻木消失率比较无统计学差异(P0.05)。结论以马钱子为主的郭氏疗法对中度氟骨症患者疼痛、晨僵、麻木、紧束感、抽搐症状的改善疗效确切,是治疗氟骨症的一种有效方法。     

郭氏马钱汤对中度氟骨症肘、膝关节屈伸运动的影响

目的 观察治疗前后中度氟骨症患者的肘、膝关节屈伸活动度数,评价郭氏马钱汤对中度氟骨症患者肘、膝关节届伸功能的改善作用.方法 将54例中度氟骨症患者随机分为两组,治疗组采用郭氏马钱汤治疗,8周后改服骨康宁胶囊;对照组采用空白安慰剂,8周后改服骨康宁胶囊安慰剂.结果 治疗结束时两组肘关节的屈伸功能改善明显,治疗组优于对照组(P<0.05),而膝关节的屈伸功能改善差异无统计学意义;24周随访时肘、膝关节的屈伸功能均明显改善,治疗组较对照组差异有统计学意义(P<0.05).结论 郭氏马钱汤可改善中度氟骨症患者的肘、膝关节属伸功能.     

郭氏马钱汤对中度氟骨症肘、膝关节屈伸运动的影响

目的 观察治疗前后中度氟骨症患者的肘、膝关节屈伸活动度数,评价郭氏马钱汤对中度氟骨症患者肘、膝关节届伸功能的改善作用.方法 将54例中度氟骨症患者随机分为两组,治疗组采用郭氏马钱汤治疗,8周后改服骨康宁胶囊;对照组采用空白安慰剂,8周后改服骨康宁胶囊安慰剂.结果 治疗结束时两组肘关节的屈伸功能改善明显,治疗组优于对照组(P<0.05),而膝关节的屈伸功能改善差异无统计学意义;24周随访时肘、膝关节的屈伸功能均明显改善,治疗组较对照组差异有统计学意义(P<0.05).结论 郭氏马钱汤可改善中度氟骨症患者的肘、膝关节属伸功能.     

郭氏马钱汤对中度氟骨症肘、膝关节屈伸运动的影响

目的 观察治疗前后中度氟骨症患者的肘、膝关节屈伸活动度数,评价郭氏马钱汤对中度氟骨症患者肘、膝关节届伸功能的改善作用.方法 将54例中度氟骨症患者随机分为两组,治疗组采用郭氏马钱汤治疗,8周后改服骨康宁胶囊;对照组采用空白安慰剂,8周后改服骨康宁胶囊安慰剂.结果 治疗结束时两组肘关节的屈伸功能改善明显,治疗组优于对照组(P<0.05),而膝关节的屈伸功能改善差异无统计学意义;24周随访时肘、膝关节的屈伸功能均明显改善,治疗组较对照组差异有统计学意义(P<0.05).结论 郭氏马钱汤可改善中度氟骨症患者的肘、膝关节属伸功能.     

中药疗法改善中度氟骨症患者肢体关节功能的随机对照研究

Objective To observe the improving effect in joint function of moderate skeletal fluorosis treated by traditional Chinese medication(main ingredient was Strychnine).Methods From December 2007 to July 2009,120 moderate skeletal fluorosis patients met the inclusion criteria were divided into the treatment group(60 cases)and the control group(60 cases)in the skeletal fluorosis hospital of Xinzhou,the treatment group was given basic treatment and traditional Chinese medication,the control group wa8 given basic treatment and placebo.The treatment lasted 12 weeks,follow up 24 weeks.Before treatment,after treatment 4 weeks,8 weeks,12 weeks,36 weeks,a third party evaluate comprehensive function of both upper and lower limb and joint dysfunction.Results The main effect of both drugs was statistically significance in the scores of the upper forearm in the finger by touching the posterior contralateral ear, upper arm touched by the finger back in the opposite corner subscapularis function, lower limb function and single-joint dysfunction(F values were 4.08,14.32,35.81,13.02, all P<0.05), the main effect of time also was significant (F values were 82.63,72.82,277.33,328.16, all P<0.05),①the upper forearm in the finger by touching the posterior contralateral ear functions:At the time of 8,12 weeks,scores of the treatment group were lower than those of before treatment and control group (all P<0.05);At the time of 36 weeks,scores of the treatment group were lower than that 12 weeks(all P<0.05);At the time of 8,12,36 weeks, scores of the control group were lower than those of before treatment(all P < 0.05);②upper arm function, namely fingers touching the opposite corner subscapularis:At the time of 4,8,12 weeks, scores of the treatment group were lower than those of before treatment(all P<0.05); At the time of 36 weeks, scores of the treatment group were lower than that 12 weeks(all P<0.05); At the time of 8,12,36 weeks, scores of the treatment group were lower than those of the control group (all P<0.05);③Lower extremity functions: At the time of 8,12 weeks,scores of the treatment group were lower than those of before treatment and control group (all P<0.05);At the time of 36 weeks, scores of the treatment group were lower than that 12 weeks(all P<0.05) ; At the time of 8,12,36 weeks, scores of the control group were lower than those of before treatment (all P<0.05);④single joint functions:At the time of 4,8,12 weeks,scores of the treatment group were lower than those of before treatment(all P<0.05); At the time of 36 weeks,scores of the treatment group were lower than that 12 weeks(all P<0.05) ; At the time of 8,12,36 weeks, scores of the control group were lower than those of before treatment(all P<0.05);At the time of 4,8,12,36 weeks, scores of the treatment group were lower than those of control group(all P<0.05);⑤At the end of treatment and follow-up,the improvement rate in joint functions in the treatment group were 88.33% (53/60),93.33% (56/60); the control group were 28.07%(16/57),40.35%(23/57), (Fisher test, P<0.01,X2=56.21, P<0.01). Conclusion Traditional Chinese medication(its main ingredient is Strychnine), an effective drug for improving joint dysfunction in patients suffering from moderate skeletal fluorosis, is simple and effective.