1855例狂犬疫苗接种后不良反应文献的分析

目的：探讨狂犬疫苗接种后不良反应的一般规律及特点,为观察狂犬疫苗不良反应提供参考。方法检索1975～2014年中国知网中公开报道的有关狂犬疫苗不良反应的个案病例报道,并进行分类统计与分析。结果共检索到173篇符合标准的文献,合计1855例;在本次统计的病例中,不良反应以20～40岁居多,占40.92%。不良反应多发生于注射后1～12 h内,达到45.56%,以第1、3、4针较多。Vero细胞培养的疫苗不良反应发生率最高,构成比为54.49%,多为皮肤系统疾病;其次为原代地鼠肾细胞培养的疫苗不良反应,构成比为41.46%,多为过敏反应。动物脑组织狂犬疫苗以神经系统并发症为主,构成比为3.49%。结论狂犬疫苗引起不良反应的原因较多,临床应加以重视,在接种时和接种后都应密切监察,以减少不良反应的发生并及时抢救。     

缝纫女工下背痛的危险因素调查

缝纫女工下背痛的危险因素调查安徽医科大学劳动卫生教研室（２３００３２）杨永坚，胡传来，朱启星合肥市劳动安全卫生检测站童宁，杜平在工业发达国家，职业性慢性肌肉骨骼损伤目前已成为主要的职业健康问题，其中下背痛尤为突出，迄今有关坐位作业与下背痛关系的研究颇...     

氯沙坦治疗原发性高血压临床疗效观察

目的观察氯沙坦治疗高血压的临床疗效。方法选择门诊符合高血压病诊断的49例患者,随机分为2组:氯沙坦组口服氯沙坦50 mg,1次/d;卡托普利组口服卡托普利12.5 mg,3次/d。2组各服药4周。记录治疗期间发生的不良反应,同时记录偶测血压,并行动态血压监测。结果氯沙坦组总有效率(90%)明显优于卡托普利组(76%),有显著性差异(P<0.05);氯沙坦组治疗后的偶测血压和24 h动态血压降低程度优于卡托普利组,有显著性差异(P<0.05)。结论氯沙坦对轻中度高血压降压效果良好,且无明显不良反应。     

早期应用辛伐他汀干预不稳定型心绞痛的疗效观察

目的观察不稳定型心绞痛患者早期应用辛伐他汀的疗效。方法将59例诊断为不稳定型心绞痛的患者随机分为治疗组和对照组,对照组予常规治疗,治疗组在常规治疗的基础上加用辛伐他汀10 mg/d,疗程3个月。分别于治疗前后查血脂,对比治疗后血脂水平及临床心脏事件发生情况。结果与对照组比较,治疗组治疗3个月后TC和LDL-C下降明显,心血管事件发生率低,有显著性差异(P均<0.05)。结论不稳定型心绞痛患者早期使用辛伐他汀治疗可降低血脂水平,降低主要心血管事件发生率。     

RELATIONSHIP BETWEEN BREAST PARENCHYMAL PATTERN AND BREAST CANCER INCIDENCE

We studied the relationship between breast parenchymal pattern and the incidence of breast cancer. The material included l,564 normal subjects of a mass survey and 552 pathologically proved cases. The incidence of breast parenchymal pattems of the two groups was compared and no relation- ship was shown between dense type and breast cancer. The "high risk group" opinion remains to be proved. We find that clinical management of breast disease and mass surveys can not be based on breast X-ray parenchymal pattern.     

高原地区成年房间隔缺损伴肺动脉高压患者血清脑钠肽水平的变化

目的 探讨高原地区房间隔缺损(ASD)患者血浆脑钠肽(BNP)及内皮素(ET-1)浓度的变化以及与肺动脉压力间的关系.方法 105例患者确诊为单纯房间隔缺损(ASD),分为ASD并肺动脉高压组(ASD-PH)和ASD无肺动脉高压组(ASD-nPH),ASD-PH组又分为ASD并轻度肺动脉高压和ASD并中重度肺动脉高压组.所有患者按居住地海拔分2000～2 500m组、2 501～3 500m组及＞3500m组.放射免疫法测定血浆BNP浓度,ELISA法测定ET-1.结果 ASD-PH组患者血清BNP、ET-1的水平明显高于ASD-nPH组,分别为(152.34±40.61) pg/ml对(126.70±32.27) pg/ml和(137.69±37.17)pg/ml对(92.92±32.3) pg/ml.不同程度肺高压患者的血浆BNP及ET-1水平存在显著差异(F=6.782,P＜0.05;F=8.475,P＜0.05).不同海拔ASD患者血浆BNP及ET-1亦存在显著差异(F=6.846,P＜0.05;F=9.327,P＜0.05).ASD患者血浆BNP与平均肺动脉压(mPAP)及缺损大小正相关(分别为r=0.326,P＜0.05和r=0.301,P＜0.05),与患者居住海拔呈正相关(r=0.252,P＜0.05).结论 ASD-PH组患者血清BNP、ET-1的水平明显高于ASD-nPH组,随着肺动脉高压程度的增加及海拔的上升二者均升高,ET、BNP共同参与了肺动脉高压的发生发展,低氧环境促进了ET、BNP的分泌.     

corilagin protects non-alcoholic fatty liver disease in mice induced by high fat and high sugar diet via regulating AMPK-autophagy signaling北大核心CSCD

Aim To explore the effects of corilagin on non-alcoholic fatty liver disease induced by high-fat and high-sugar diet in mice via regulating AMPK-autophagy signaling. Methods Healthy 8-week-old male C57BL/6J mice were randomly divided into control group, model group and corilagin group. The mice of model group and corilagin group were fed with a high-fat and high-sugar diet for four weeks at the age of eight weeks. The corilagin group mice were also intraperitoneally injected with corilagin (20 mg • k g - 1 ), which was given once every 2 days for 4 weeks. The mice of the control group and the model group were given equal dose of normal saline. After modeling and administration, the mice were sacrificed and the liver weight recorded. The liver pathological changes of each group mice were assessed by HE staining, oil red O staining and Masson staining. The biochemical indexes in serum and liver tissue were detected by the ELISA kit. The p-AMPK and autophagy levels were detected by Western blot. Results The results showed that compared to control group, the liver weight of the model group increased, the AST and ALT levels in serum also significantly increased, there were a large number of fat vacuoles and severe lipid deposition and mild collagen fibrosis in liver, while the liver weight and TG level in liver significantly decreased, and the liver pathological changes were significantly improved after treated with corilagin. Western blot results showed the levels of autophagy related proteins such as Atg7 and Atg5 significantly decreased in the model group, and the p-AMPK level also significantly decreased. When treated with corilagin, p-AMPK and the autophagy levels were up-regulated. Conclusion corilagin can protect non-alcoholic fatty liver disease in mice induced by high fat and high sugar diet. The mechanism may involve increasing p-AMPK level and enhancing autophagy level in liver. © 2023 Publication Centre of Anhui Medical University. All rights reserved.     

水飞蓟宾导致慢性肝炎患者缺铁性贫血的研究

目的：研究水飞蓟宾对慢性肝炎患者缺铁性贫血的影响。方法：选取120例慢性肝炎患者分为两组（每组60例）,两组患者在性别、年龄、临床类型及肝功能等实验室检查指标上均无显著性差异。对照组服用多烯磷脂酰胆碱（易善复,赛诺菲安万特制药有限公司）,剂量为70~140 mg,口服,每日3次,12周为一个疗程;试验组服用水飞蓟宾（水林佳,天津天士力制药有限公司）,剂量为70~140 mg,口服,每日3次,12周为一个疗程。两组于治疗前、治疗2周、治疗结束后4周测定血红蛋白、血清铁蛋白、血清铁。结果：对照组60例中,服药前后,血红蛋白、血清铁蛋白、血清铁均无显著变化;试验组60例,给药后血红蛋白、血清铁蛋白、血清铁的差异有显著性意义（P<0.05）。结论：水飞蓟宾会导致慢性肝炎患者缺铁性贫血的发生。     

质量控制在临床免疫检验中的作用分析

目的:分析质量控制在临床免疫检验中的作用.方法:将2018年1月至2019年7月在本院实施免疫检验的78例患者视为研究对象,以电脑随机编号法划入常规组与质控组(n=39).常规组实施常规检测,质控组在此基础上实施免疫检验分析质量控制干预,比较患者的免疫检验平均变异指数及患者检验期间的工作满意率.结果:质控组患者的CEA、AFP、CA125及CA199变异指数均低于常规组患者,两组数据比较有统计学意义(P<0.05).常规组患者对检验工作实施的满意率为79.49%,质控组患者对检验工作实施的满意率为97.44%,质控组患者的满意率更高(P<0.05).结论:质量控制在临床免疫检验中的使用,能够降低免疫检验中各类指标的变异指数,提升患者的免疫检验工作满意率.