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梭状芽胞杆菌 (Clostridium)是机体肠道正常菌群。产气荚膜梭菌 (Cl.perfringen简写Cl.p)是其中少数致病菌之一 ,健康成人的分离率为 5 2 % ,而老人则为 92 % 〔1〕。有关学者对它产生的腐败作用和在消化道肿瘤发生的相关性较为关注〔2〕。本文报告昆明种小鼠长期饲Cl.p后 ,其胃肠粘膜组织病理变化、肝细胞增生和肠道菌群变化。1 材料与方法1 1 实验动物 昆明种小鼠 30只 ,雌雄各半 ,体重 18~ 2 0g,由河南医科大学动物中心供应 ,封闭饲养。1 2 菌株 产气荚膜梭菌购自中国药品生物制品鉴定所 ,菌号 6 47… 相似文献
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核仁形成区相关嗜银蛋白与上皮细胞增殖 总被引:3,自引:0,他引:3
应用放射自显影和银染技术检测Wistar大鼠食管和小肠上皮细胞增殖状态结果表明:食管底层细胞3H-TdR标记率0.21,AgNORs数目1.77,高于浅层细胞的0.05和1.40(P<0.005)。肠腺上皮细胞3H-TdR标记率为0.75,AgNORs数目2.77,高于绒毛上皮细胞的0.50和2.05(P<0.001)。3H-TdR标记率和AgNORs数目在底层细胞(r=0.86)、浅层细胞(r=0.88)、肠腺细胞(r=0.91)和绒毛细胞(r=0.67)均呈直线密切正相关。提示:上皮细胞中AgNORs数目与DNA合成同步增长;AgNORS数目准确标示了不同增殖状态细胞群体,是反映细胞增殖水平的敏感指标。 相似文献
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应用酶联免疫组织化学SABC法和血型抗原A、B、H、Le~a和Le~b的单克隆抗体,对15例胎儿和正常成人食管及14例早期和51例晚期食管癌组织检测,结果表明:食管癌组织ABH血型抗原表现出不同程度的丢失、前体物H抗原积聚及不相容性表达。这些改变在癌变早期就已存在,可以作为食管癌变的一个免疫组织化学的辅助诊断指标;在一定程度上反映出食管癌组织的病理学分期和分化程度。Lewis抗原的表达改变有利推测癌组织潜在的淋巴结转移可能性。 相似文献
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On cytosmears of esophageal epithelium of individuals from high-risk area of esophageal cancer squamous epithelial cells, according to standard cytologic diagnostic criteria, can be categorized as normal, hyperplasia, severely dysplastic grade I and grade II, nearly-carcinoma and early carcinoma. Cytosmears from 60 patients, 10 for each category, were studied with a semiautomatic image analysis system. Thirteen morphologic parameters so obtained were further analyzed by computer-based stepwise regression and linear correlation analyses. The results showed that the following 5 parameters could be used to judge the nature of the cells, i.e. a) cytoplasmic area, b) cytoplasmic mean diameter, c) cytoplasmic form factor, d) nuclear form factor and e) N/C ratio. Comparing with cells of the other categories, values of the first 4 parameters for early cancer cells were decreased whereas that of the fifth parameter was significantly increased. From normal to hyperplastic and to dysplastic cells, the nuclear area and mean nuclear diameter were gradually increasing. Therefore, they were the major parameters in judging the degree of hyperplasia and dysplasia. These numerical features of morphologic quantitation conformed with the cytologic diagnostic criteria for cancer, hyperplasia and dysplasia under light microscope. It indicates that visual judgement is relatively accurate and application of the ocular micrometer to measure the cells would make this grading more objective. 相似文献