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张珞 《糖尿病天地(学术刊)》2011,(5):34-34
炎症是生活中的常见现象。当我们不小心用一把较脏的小刀割破手指后,刀片中的细菌可能会进入到伤口当中,遇到特异的“哨兵”免疫细胞(这些细胞在体内发挥监视作用,表面有大量特异性的受体,可识别入侵的“敌人”),这时免疫系统就迅速行动起来了。我们可以通过机体表面的迹象来知道外来入侵细菌与免疫系统之间的战争: 相似文献
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This study examined the predictive value of plasma cystatin C,creatinine and estimated glomerular filtration rate (eGFR) as risk factors for cardiovascular disease in Chinese.Plasma cystatin C and creatinine were measured in 466 coronary heart disease (CHD) patients recruited from 4 hospitals and 349 healthy controls from local communities in Wuhan,China.Cockroft-Gault formula was used to estimate the glomerular filtration rate (GFR) after adjusting for body surface area.With each measure,the study population was divided into quintiles.The results showed that the patients had significantly higher levels of plasma cystatin C,creatinine,and lower level of eGFR than controls.Lower eGFR was associated with a higher risk of cardiovascular events.As compared with the first (highest) quintile,the hazard ratios (and 95% CIs) after multivariate adjustment for CHD were as follows:third quintile,2.98 (1.54-5.78);fourth quintile,3.34 (1.58-7.09);fifth quintile,4.37(1.84-10.35).With higher cystatin C quintiles (≥1.00 mg/L and ≥1.17 mg/L),the hazard ratios for CHD were 2.16 (1.23-3.81) and 2.34 (1.25-4.38),similar to those of creatinine 2.21 (1.21-4.03) and 2.03 (1.07-3.84).However,it was plasma cystatin C not eGFR or creatinine had stronger association with ischemic stroke.The highest quintile had the hazard ratio of 4.51 (1.45-14.08) after multivariate adjustment.It was concluded that plasma cystatin C,associated with renal function,is not an independent risk factor for cardiovascular disease.eGFR is a better risk predictor for CHD than plasma cystatin C and creatinine.But for ischemic stroke,plasma cystatin C is a better risk factor than creatinine and estimated GFR. 相似文献
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