丹参多酚酸盐注射液对慢性阻塞性肺疾病急性加重期患者的炎症调节作用及临床疗效分析

目的观察丹参多酚酸盐对慢性阻塞性肺疾病急性加重期(AECOPD)的临床疗效及其对IL-10、IL-6、TNF-α表达水平的影响。方法选择AECOPD患者92例,随机分为治疗组和对照组,每组46例。对照组给予西医常规疗法,治疗组在对照组基础上给予丹参多酚酸盐注射液。两组疗程均为10天,观察临床疗效及IL-10、IL-6、TNF-α的变化情况。结果治疗组和对照组总有效率分别为95.6%和82.6%,治疗组临床疗效优于对照组(P0.05)。治疗后,治疗组呼吸困难消失和肺部啰音消失时间均显著短于对照组(P0.05);治疗组和对照组FEV1占预计值百分比和FEV1/FVC均显著改善(P0.05),治疗组优于对照组(P0.05);两组IL-10均升高,IL-6和TNF-α均降低(P0.05,P0.01),治疗组与对照组差异有统计学意义(P0.01)。结论丹参多酚酸盐可以改善AECOPD患者的临床症状,并调节IL-10、IL-6、TNF-α水平的表达。     

Primary tracheobronchial amyloidosis in China: Analysis of 64 cases and a review of literature

Primary tracheobronchial amyloidosis (TBA) is a rare pulmonary disease.A systematic review was performed on 64 cases of primary TBA in China and progress in the diagnosis and treatment of this disease is discussed.The Chinese biological and medical databases from 1970 to 2010 were searched and 75 cases of complete clinical and pathological data were identified.The clinical characteristics of the disease were summarized and longitudinal comparisons were made of diagnostic and treatment methods over time.The results showed that the morbidity associated with primary TBA has increased over recent years.The clinical manifestations were non-specific.Progressive dyspnea, cough and sputum were the most common symptoms.The percentage of patients undergoing computed tomography (CT) scan has increased over the years.The bronchoscopy and transbrochial lung biopsy (TBLB) were usually sufficient to establish the diagnosis.Treatment was reported for a total of 44 cases.Bronchoscopic Nd:YAG laser irradiation, argon plasma coagulation (APC) and drugs administration such as steroids and colchicines were reported to be effective in some patients.It is concluded that the demographic characteristics and clinical manifestations of primary TBA patients in China are largely consistent with findings reported in other countries.Dramatically more cases were reported in recent years, mainly due to the extensive application of bronchoscopy since 1990s.Chest CT scan provides important clues for the diagnosis of the disease.The definite diagnosis was confirmed by bronchoscopic findings and Congo red staining of biopsy specimen.Bronchoscopic Nd:YAG laser irradiation, argon plasma coagulation (APC) and drugs administration, such as steroids and colchicines were reported to be effective in some patients.     

第174例发热-咳嗽-两肺浸润-皮下结节

病历摘要 患者男,34岁.因发热、咳嗽伴活动后胸闷、气急2周于2006年2月23日以"两肺炎"收入浙江大学医学院附属第二医院.     

人禽流感的诊治现状

禽流感是禽流行性感冒的简称，又称真性鸡瘟，是由甲型流感病毒的一种亚型（也称禽流感病毒）引起的一种传染性疾病。不仅鸡等家禽，而且野鸟也会感染并引起广泛传播和家禽大量死亡，造成巨大的经济损失。按病原体的类型，禽流感可分为高致病性、低致病性和非致病性三大类。非致病性禽流感不会引起明显症状，仅使染病的禽鸟体内产生病毒抗体；低致病性禽流感（主要是H9N2/H7N7型）可使禽类出现轻度呼吸道症状，食量减少，产蛋量下降，出现零星死亡；高致病性禽流感（主要是H5N1型）最为严重，发病率和死亡率高，感染的家禽常常大部分或全部死亡。     

血栓通注射液联合华法林、低分子肝素治疗急性肺血栓栓塞症的临床观察

目的:观察血栓通注射液联合法华林、低分子肝素治疗急性肺血栓栓塞症(PTE)的临床疗效和安全性。方法:将152例PTE患者随机均分为对照组和试验组。两组患者均予以卧床休息、吸氧等常规治疗。与此同时,对照组患者给予华法林3⁵ mg,口服,qd+低分子肝素7 500 U,皮下注射,bid;试验组患者在对照组治疗的基础上给予血栓通注射液140 mg加入0.9%氯化钠注射液100 ml中静脉滴注,qd。两组患者疗程均为14 d。观察两组患者的临床疗效,治疗前后动脉血酸碱度(p H)、动脉血氧分压[pbt(O2)]、动脉血二氧化碳分压[pbt(CO2)]等肺动脉血气指标,缺损肺动脉栓塞数及改善率,随访两组患者6个月再入院率和病死率,记录不良反应发生情况。结果:试验组患者总有效率、缺损肺动脉栓塞数改善率均显著高于对照组,两组比较差异有统计学意义(P<0.05)。治疗前两组患者p H、pbt(O2)、pbt(CO2)、缺损肺动脉栓塞数比较,差异均无统计学意义(P>0.05);治疗后两组患者p H、缺损肺动脉栓塞数均显著低于同组治疗前,且试验组低于对照组,pbt(O2)、pbt(CO2)均显著高于同组治疗前,且试验组高于对照组,差异均有统计学意义(P<0.05)。两组患者再入院率、病死率、不良反应发生率比较,差异均无统计学意义(P>0.05)。结论:血栓通注射液联合华法林、低分子肝素治疗PTE较华法林联合低分子肝素疗效更好,安全性相似。     

急性肺栓塞36例临床分析

肺栓塞（PE）是由于内源性和外源性栓子阻塞肺动脉主干或分支引起肺循环障碍的临床和病理综合征的总称,其中以肺血栓栓塞症（PET）为多见,而PET的血栓大多来源于深静脉血栓。近年来PET发病率呈逐年增加趋势,且漏诊率、误诊率和病死率均较高,而文献报道若能对本病予及时、恰当的治疗,病死率可降低至2％。现笔者将近年来收治的急性PE患者的临床资料作一回顾性分析,以期为提高本病的诊治水平提供帮助。     

肺隐球菌病合并隐球菌性脑膜炎一例

患者 ,女性 ,5 0岁。因咳嗽 1个月 ,加重伴发热半个月入院。既往体健 ,无肺结核和肿瘤史。入院查体 :T 3 8.8℃ ,P 80次 /分 ,R 18次 /分 ,BP 12 0 /80mmHg ,神志清 ,双瞳孔等圆等大 ,颈软 ,双肺呼吸音粗 ,未闻干、湿性罗音 ,心、肝、脾检查未见异常 ,神经系统无阳性体征。WBC 10 .6× 10 9/L ,N 0 .86,L 0 .14 ,肝、肾功能检查正常。胸片检查见右肺下叶团块影 ,疑为肺癌。胸部CT检查结果为右肺下叶结节灶 ,首先考虑为炎症。入院后经丁胺卡那霉素、头孢呋肟治疗 2天后症状无好转 ,体温不降 ,并出现持续头痛且加重 ,伴恶心、呕吐。查体…     

胸痛发热白细胞下降

1病例摘要患者女,24岁,医学院学生。因胸痛伴发热1个月,咳嗽咳痰1周入院。患者于入院1个月前劳累后出现胸痛,持续存在,呼气时加重,以左前胸为主,疼痛较锐利,无放射,自觉发热,体温未测,自服“日夜百服宁”,体温有所下降,但胸痛无缓解,遂来我院就诊。X线胸片提示左下肺大片高密度     

读片园地 第75例——右下肺后类圆形肿块

患者女性,22岁,因高考体检发现右肺肿块2个月于2004年6月入院。追问病史患者2个多月前偶感活动后气急,伴轻微咳嗽、咳痰及痰中带血,无胸痛不适及无发热,不影响日常学习和生活。体检时摄X线胸片示:右下肺后近心缘处有一团块影。心脏超声示:无异常。胸部CT示:右下后纵隔囊性占位性病变,考虑纵隔肿瘤。患者既往史、个人史、家族史均无特殊。入院体检:皮肤巩膜无黄染,锁骨上淋巴结未触及,甲状腺Ⅱ°肿大,未触及结节,未闻及血管杂音。两肺呼吸音清,未闻及干湿啰音摹⒏共刻寮煳抟斐?体征。实验室检查:血、尿、便常规、红细胞沉降率、血生化、…