全文获取类型
收费全文 | 901篇 |
免费 | 77篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 47篇 |
妇产科学 | 31篇 |
基础医学 | 138篇 |
口腔科学 | 17篇 |
临床医学 | 122篇 |
内科学 | 142篇 |
皮肤病学 | 10篇 |
神经病学 | 106篇 |
特种医学 | 14篇 |
外科学 | 78篇 |
综合类 | 8篇 |
一般理论 | 1篇 |
预防医学 | 96篇 |
眼科学 | 23篇 |
药学 | 62篇 |
肿瘤学 | 82篇 |
出版年
2023年 | 9篇 |
2022年 | 6篇 |
2021年 | 24篇 |
2020年 | 35篇 |
2019年 | 34篇 |
2018年 | 35篇 |
2017年 | 23篇 |
2016年 | 25篇 |
2015年 | 32篇 |
2014年 | 38篇 |
2013年 | 50篇 |
2012年 | 60篇 |
2011年 | 60篇 |
2010年 | 35篇 |
2009年 | 23篇 |
2008年 | 47篇 |
2007年 | 54篇 |
2006年 | 41篇 |
2005年 | 31篇 |
2004年 | 43篇 |
2003年 | 31篇 |
2002年 | 30篇 |
2001年 | 11篇 |
2000年 | 9篇 |
1999年 | 15篇 |
1998年 | 6篇 |
1997年 | 7篇 |
1994年 | 5篇 |
1992年 | 8篇 |
1991年 | 16篇 |
1990年 | 15篇 |
1989年 | 10篇 |
1988年 | 7篇 |
1987年 | 8篇 |
1983年 | 4篇 |
1981年 | 3篇 |
1980年 | 3篇 |
1979年 | 5篇 |
1978年 | 5篇 |
1976年 | 5篇 |
1975年 | 7篇 |
1973年 | 4篇 |
1972年 | 4篇 |
1971年 | 4篇 |
1969年 | 4篇 |
1966年 | 4篇 |
1965年 | 5篇 |
1940年 | 5篇 |
1938年 | 5篇 |
1932年 | 3篇 |
排序方式: 共有979条查询结果,搜索用时 156 毫秒
1.
Blood Flow Imaging in Transesophageal Echocardiography during Atrial Septal Defect Closure: A Comparison with the Current References 下载免费PDF全文
Siri Ann Nyrnes M.D. Lasse Løvstakken M.Sc. Ph.D. Gaute Døhlen M.D. Ph.D. Eirik Skogvoll M.D. Ph.D. Hans Torp M.Sc. Dr.Tech. Terje Skjærpe M.D. Ph.D. Gunnar Norgård M.D. Ph.D. Stein Samstad M.D. Ph.D. Torbjørn Graven M.D. Bjørn Olav Haugen M.D. Ph.D. 《Echocardiography (Mount Kisco, N.Y.)》2015,32(1):34-41
2.
3.
4.
Changes in Right Ventricular Shape and Deformation Following Coronary Artery Bypass Surgery—Insights from Echocardiography with Strain Rate and Magnetic Resonance Imaging 下载免费PDF全文
5.
Rujira Rujiwetpongstorn Mati Chuamanochan Napatra Tovanabutra Romanee Chaiwarith Siri Chiewchanvit 《The Journal of dermatology》2020,47(6):563-568
Reactive neutrophilic dermatoses in adult-onset immunodeficiency due to interferon-γ autoantibody (AOID) are usually associated with concomitant active opportunistic infections. Data focusing on the treatment of these dermatoses with non-immunosuppressive drugs are still lacking. The aim of this study was to assess the efficacy and safety of acitretin treatment of reactive neutrophilic dermatoses in AOID. We conducted a retrospective review of all patients with AOID who had reactive neutrophilic dermatoses and had been treated with acitretin from January 2008 to December 2018. In total, 23 patients had been diagnosed with AOID, with 27 episodes of reactive neutrophilic dermatoses (20 episodes of Sweet syndrome and seven episodes of generalized pustular eruption) and treated with acitretin. The median effective dose of acitretin was 10 mg/day. The mean initial response was 5.6 ± 2.3 days. The rash had almost or completely cleared within 2 weeks in 70.4% of patients. One case had developed a reversible acitretin-induced liver injury with hepatocellular pattern. The median total duration of treatment was 3 months. In conclusion, this study demonstrates the potential role of acitretin as one of the treatments of choice for reactive neutrophilic dermatoses in AOID, attributable to its favorable response and good tolerability. 相似文献
6.
7.
Alessandro Mega Mette Hartmark Nilsen Lina Wik Leiss Nicholas P. Tobin Hrvoje Miletic Linda Sleire Carina Strell Sven Nelander Cecilia Krona Daniel Hägerstrand Per Ø. Enger Monica Nistér Arne Östman 《Glia》2020,68(2):316-327
Glioblastoma (GBM) is a deadly disease with a need for deeper understanding and new therapeutic approaches. The microenvironment of glioblastoma has previously been shown to guide glioblastoma progression. In this study, astrocytes were investigated with regard to their effect on glioblastoma proliferation through correlative analyses of clinical samples and experimental in vitro and in vivo studies. Co-culture techniques were used to investigate the GBM growth enhancing potential of astrocytes. Cell sorting and RNA sequencing were used to generate a GBM-associated astrocyte signature and to investigate astrocyte-induced GBM genes. A NOD scid GBM mouse model was used for in vivo studies. A gene signature reflecting GBM-activated astrocytes was associated with poor prognosis in the TCGA GBM dataset. Two genes, periostin and serglycin, induced in GBM cells upon exposure to astrocytes were expressed at higher levels in cases with high “astrocyte signature score”. Astrocytes were shown to enhance glioblastoma cell growth in cell lines and in a patient-derived culture, in a manner dependent on cell–cell contact and involving increased cell proliferation. Furthermore, co-injection of astrocytes with glioblastoma cells reduced survival in an orthotopic GBM model in NOD scid mice. In conclusion, this study suggests that astrocytes contribute to glioblastoma growth and implies this crosstalk as a candidate target for novel therapies. 相似文献
8.
Journal of Neurology - Measurement of CSF opening pressure (CSFOP) is valuable and much used in the investigation of several neurological conditions. However, there are different opinions regarding... 相似文献
9.
Tone K Omsland John A Eisman Øyvind Næss Jacqueline R Center Clara G Gjesdal Grethe S Tell Nina Emaus Haakon E Meyer Anne Johanne Søgaard Kristin Holvik Berit Schei Siri Forsmo Jeanette H Magnus 《Journal of bone and mineral research》2015,30(12):2221-2228
Hip fractures are associated with high excess mortality. Education is an important determinant of health, but little is known about educational inequalities in post‐hip fracture mortality. Our objective was to investigate educational inequalities in post‐hip fracture mortality and to examine whether comorbidity or family composition could explain any association. We conducted a register‐based population study of Norwegians aged 50 years and older from 2002 to 2010. We measured total mortality according to educational attainment in 56,269 hip fracture patients (NORHip) and in the general Norwegian population. Both absolute and relative educational inequalities in mortality in people with and without hip fracture were compared. There was an educational gradient in post‐hip fracture mortality in both sexes. Compared with those with primary education only, the age‐adjusted relative risk (RR) of mortality in hip fracture patients with tertiary education was 0.82 (95% confidence interval [CI] 0.77–0.87) in men and 0.79 (95% CI 0.75–0.84) in women. Additional adjustments for Charlson comorbidity index, marital status, and number of children did not materially change the estimates. Regardless of educational attainment, the 1‐year age‐adjusted mortality was three‐ to fivefold higher in hip fracture patients compared with peers in the general population without fracture. The absolute differences in 1‐year mortality according to educational attainment were considerably larger in hip fracture patients than in the population without hip fracture. Absolute educational inequalities in mortality were higher after hip fracture compared with the general population without hip fracture and were not mediated by comorbidity or family composition. Investigation of other possible mediating factors might help to identify new targets for interventions, based on lower educational attainment, to reduce post‐hip fracture mortality. © 2015 American Society for Bone and Mineral Research. 相似文献
10.