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1.
Mariantonieta Tirado Sheila M. Dobin Martin P. Fernandez Arundhati Rao 《Journal of cutaneous pathology》2021,48(1):116-122
A 21‐year‐old female presented with a 5‐year history of an erythematous papule on her right breast. The biopsy showed a dense, dermal nodular infiltrate, extending focally into the subcutaneous tissue. The infiltrate was composed predominantly of pleomorphic cells with bi‐lobed, multi‐lobed, horseshoe, or ring‐shaped nuclei. There was a smaller subset of monomorphous cells characterized by a round, reniform, or elongated single‐lobed nucleus. Accompanying cells included few foamy histiocytes, lymphocytes, and numerous scattered eosinophils. No necrosis, vascular invasion, or ulceration was present. The pleomorphic and monomorphic granular cells were positive for Giemsa stain as well as for tryptase, CD117, CD68, CD2, and CD30 immunohistochemistry and negative for S100, CD1a, myeloperoxidase, lysozyme, and CD56. Clinical examination was negative for any additional similar lesions and serum tryptase was within normal limits. The bone marrow was not biopsied. In addition, fluorescent in situ hybridization revealed multiple clones with loss of number 5 chromosome and PDGFRA and HRAS mutations. The lesion did not recur or progress after a 6‐year clinical follow‐up. To our full knowledge, we report the first case of pleomorphic mastocytoma with loss of chromosome 5 and PDGFRA and HRAS mutations. 相似文献
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Biologics and immunomodulators (IMM) are generally considered the most effective therapies for the treatment of ulcerative colitis and Crohn’s disease. However, despite the efficacy of these therapies, many patients either have a primary lack of response or a secondary loss of response to these medications. Therapeutic drug monitoring (TDM) is a systematic approach to managing such patients. In this review, we summarize the latest data on TDM, including reactive and proactive TDM, in patients with inflammatory bowel disease on biologics and/or IMM. 相似文献
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目的探讨微波热疗联合三联药物膀胱灌注治疗膀胱疼痛综合征/间质性膀胱炎(BPS/IC)的临床效果与安全性。
方法回顾性分析2014年2月至2017年9月收治的51例BPS/IC患者的临床资料,其中女44例,男7例,平均年龄36岁,平均病程32个月。对照组采用单纯三联药物膀胱灌注,治疗组在膀胱灌注的基础上运用微波热疗治疗。所有患者治疗前后均行O'Leary-Sant间质性膀胱炎症状指数和问题指数评分(ICSI/ICPI),盆腔疼痛及尿频评分(PUF)和VAS疼痛评分以评估疗效。
结果经治疗后,治疗组患者ICSI、ICPI、PUF及VAS评分均优于对照组[(7.3±3.3) vs(10.7±2.5)、(5.2±3.5)vs(7.5±3.5)、(19.6±3.4)vs(22.3±4.7)、(5.0±0.7)vs(5.8±1.1),P值均<0.05)],且两组患者治疗后各项评分均优于治疗前(P<0.05),治疗组患者有效率为91.7%,所有患者均未发生严重不良反应。
结论微波热疗联合药物膀胱灌注治疗BPS/IC的疗效肯定,适合广泛开展,为临床治疗BPS/IC提供了一种有效方法。 相似文献
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Indian Journal of Pediatrics - 相似文献
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Suwarna Chakraborty Sunil Jamuna Tripathi B.N. Srikumar T.R. Raju B.S. Shankaranarayana Rao 《Brain stimulation》2019,12(3):752-766
Background
Major depressive disorder (MDD) is a multifactorial disease which often coexists with cognitive deficits. Depression-induced cognitive deficits are known to be associated with aberrant reward processing, neurochemical and structural alterations. Recent studies have shown that chronic electrical stimulation of brain reward areas induces a robust antidepressant effect. However, the effects of repeated electrical self-stimulation of lateral hypothalamus - medial forebrain bundle (LH-MFB) on depression-induced cognitive deficits and associated neurochemical and structural alterations in the prefrontal cortex (PFC) are unknown.Objectives
We investigated the effect of chronic rewarding self-stimulation of LH-MFB in neonatal clomipramine (CLI) model of depression. During adulthood, neonatal CLI and saline administered rats were implanted with bilateral electrodes stereotaxically in the LH-MFB and trained to receive intracranial self-stimulation (ICSS) for 14 days. The rats were tested for depressive-like behaviors, learning and memory followed by estimation of PFC volumes, levels of monoamines and its metabolites in the PFC.Results
We found that chronic ICSS of LH-MFB reverses CLI-induced behavioral despair and anhedonia. Interestingly, self-stimulation normalizes the impaired novel object and location recognition memory in CLI rats. The amelioration of learning impairments in CLI rats was associated with the reversal of volume loss and restoration of monoamine metabolism in the PFC.Conclusion
We demonstrated that repeated intracranial self-stimulation of LH-MFB ameliorates CLI-induced learning deficits, reverses altered monoamine metabolism and the atrophy of PFC. Our results support the hypothesis that chronic brain stimulation rewarding experience might be evolved as a potential treatment strategy for reversal of learning deficits in depression and associated disorders. 相似文献7.
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Sharma Kirti Kumari Hales Tim G. Rao Vaidya Jayathirtha NicDaeid Niamh McKenzie Craig 《Forensic Toxicology》2019,37(1):1-16
Forensic Toxicology - A detailed review on the chemistry and pharmacology of non-fentanil novel synthetic opioid receptor agonists, particularly N-substituted benzamides and acetamides (known... 相似文献
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