首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   1592049篇
  免费   132063篇
  国内免费   2517篇
耳鼻咽喉   21623篇
儿科学   52799篇
妇产科学   46089篇
基础医学   226015篇
口腔科学   47186篇
临床医学   139517篇
内科学   311838篇
皮肤病学   34050篇
神经病学   129292篇
特种医学   64665篇
外国民族医学   474篇
外科学   243686篇
综合类   39647篇
一般理论   545篇
预防医学   121817篇
眼科学   36447篇
药学   121124篇
  2篇
中国医学   2887篇
肿瘤学   86926篇
  2018年   14613篇
  2016年   12820篇
  2015年   14937篇
  2014年   20650篇
  2013年   31375篇
  2012年   42662篇
  2011年   44847篇
  2010年   26364篇
  2009年   25318篇
  2008年   43075篇
  2007年   45330篇
  2006年   46146篇
  2005年   44771篇
  2004年   44212篇
  2003年   42197篇
  2002年   41338篇
  2001年   75711篇
  2000年   78281篇
  1999年   66092篇
  1998年   16747篇
  1997年   15356篇
  1996年   15298篇
  1995年   15972篇
  1994年   15017篇
  1993年   14174篇
  1992年   55445篇
  1991年   53815篇
  1990年   52593篇
  1989年   50872篇
  1988年   47267篇
  1987年   46600篇
  1986年   44313篇
  1985年   42889篇
  1984年   32024篇
  1983年   27553篇
  1982年   16102篇
  1981年   14383篇
  1980年   13507篇
  1979年   30435篇
  1978年   21031篇
  1977年   17696篇
  1976年   16621篇
  1975年   17500篇
  1974年   21426篇
  1973年   20629篇
  1972年   18821篇
  1971年   17734篇
  1970年   16264篇
  1969年   15256篇
  1968年   13942篇
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
Modified-release opioids are often prescribed for the management of moderate to severe acute pain following total hip and knee arthroplasty, despite recommendations against their use due to increasing concerns regarding harm. The primary objective of this multicentre study was to examine the impact of modified-release opioid use on the incidence of opioid-related adverse events compared with immediate-release opioid use, among adult inpatients following total hip or knee arthroplasty. Data for total hip and knee arthroplasty inpatients receiving an opioid analgesic for postoperative analgesia during hospitalisation were collected from electronic medical records of three tertiary metropolitan hospitals in Australia. The primary outcome was the incidence of opioid-related adverse events during hospital admission. Patients who received modified with or without immediate-release opioids were matched to those receiving immediate-release opioids only (1:1) using nearest neighbour propensity score matching with patient and clinical characteristics as covariates. This included total opioid dose received. In the matched cohorts, patients given modified-release opioids (n = 347) experienced a higher incidence of opioid-related adverse events overall, compared with those given immediate-release opioids only (20.5%, 71/347 vs. 12.7%, 44/347; difference in proportions 7.8% [95%CI 2.3–13.3%]). Modified-release opioid use was associated with an increased risk of harm when used for acute pain during hospitalisation after total hip or knee arthroplasty.  相似文献   
3.
Pharmaceutical Chemistry Journal - Metformin hydrochloride is widely used to treat diabetes mellitus. This review presents its physical and chemical properties and discusses methods of analysis...  相似文献   
4.
Khadka  J.  Ratcliffe  J.  Hutchinson  C.  Cleland  J.  Mulhern  B.  Lancsar  E.  Milte  R. 《Quality of life research》2022,31(9):2849-2865
Quality of Life Research - To evaluate the construct (convergent and known group) validity of the Quality-of-Life-Aged Care Consumer (QOL-ACC), an older-person-specific quality-of-life measure...  相似文献   
5.
6.
7.
8.
9.
PurposeTRAPPC9 deficiency is an autosomal recessive disorder mainly associated with intellectual disability (ID), microcephaly, and obesity. Previously, TRAPPC9 deficiency has not been associated with biochemical abnormalities.MethodsExome sequencing was performed in 3 individuals with ID and dysmorphic features. N-Glycosylation analyses were performed in the patients’ blood samples to test for possible congenital disorder of glycosylation (CDG). TRAPPC9 gene, TRAPPC9 protein expression, and N-glycosylation markers were assessed in patient fibroblasts. Complementation with wild-type TRAPPC9 and immunofluorescence studies to assess TRAPPC9 expression and localization were performed. The metabolic consequences of TRAPPC9 deficiency were evaluated using tracer metabolomics.ResultsAll 3 patients carried biallelic missense variants in TRAPPC9 and presented with an N-glycosylation defect in blood, consistent with CDG type I. Extensive investigations in patient fibroblasts corroborated TRAPPC9 deficiency and an N-glycosylation defect. Tracer metabolomics revealed global metabolic changes with several affected glycosylation-related metabolites.ConclusionWe identified 3 TRAPPC9 deficient patients presenting with ID, dysmorphic features, and abnormal glycosylation. On the basis of our findings, we propose that TRAPPC9 deficiency could lead to a CDG (TRAPPC9-CDG). The finding of abnormal glycosylation in these patients is highly relevant for diagnosis, further elucidation of the pathophysiology, and management of the disease.  相似文献   
10.
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号